Entry Database : PDB / ID : 5cuj Structure visualization Downloads & linksTitle Crystal structure of Human Defensin-5 Y27A mutant crystal form 2. ComponentsDefensin-5 Details Keywords ANTIMICROBIAL PROTEIN / PANETH CELLS DEFENSIN / HUMAN ALPHA-DEFENSIN / INTESTINAL DEFENSINFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of membrane permeability / Defensins / disruption of plasma membrane integrity in another organism / killing by host of symbiont cells / Alpha-defensins / defense response to fungus / transport vesicle / extracellular matrix / innate immune response in mucosa / secretory granule ... positive regulation of membrane permeability / Defensins / disruption of plasma membrane integrity in another organism / killing by host of symbiont cells / Alpha-defensins / defense response to fungus / transport vesicle / extracellular matrix / innate immune response in mucosa / secretory granule / positive regulation of interleukin-8 production / Golgi lumen / antimicrobial humoral immune response mediated by antimicrobial peptide / midbody / antibacterial humoral response / cellular response to lipopolysaccharide / protein homotetramerization / secretory granule lumen / defense response to Gram-negative bacterium / killing of cells of another organism / defense response to Gram-positive bacterium / intracellular membrane-bounded organelle / innate immune response / protein homodimerization activity / extracellular space / extracellular region Similarity search - Function Mammalian defensins signature. / Alpha-defensin, C-terminal / Mammalian defensin / Defensin propeptide / Alpha-defensin propeptide / Alpha-defensin / Defensin propeptide / Beta/alpha-defensin, C-terminal / Defensin/corticostatin family Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.08 Å DetailsAuthors Tolbert, W.D. / Gohain, N. / Pazgier, M. CitationJournal : Immunity / Year : 2018Title : Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.Authors : Xu, D. / Liao, C. / Zhang, B. / Tolbert, W.D. / He, W. / Dai, Z. / Zhang, W. / Yuan, W. / Pazgier, M. / Liu, J. / Yu, J. / Sansonetti, P.J. / Bevins, C.L. / Shao, Y. / Lu, W. History Deposition Jul 24, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 27, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jun 13, 2018 Group : Data collection / Database references / Derived calculationsCategory : citation / citation_author ... citation / citation_author / pdbx_struct_oper_list / pdbx_struct_special_symmetry Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _pdbx_struct_oper_list.symmetry_operation Revision 1.2 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id
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