登録情報 | データベース: PDB / ID: 5bqb |
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タイトル | Crystal structure of Norrin, a Wnt signalling activator, Crystal Form III |
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要素 | Norrin |
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キーワード | SIGNALING PROTEIN / Wnt signalling pathway / Norrie disease protein / cystine-knot like growth factor / ligand for Frizzled 4 receptor |
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機能・相同性 | 機能・相同性情報
retina blood vessel maintenance / cone retinal bipolar cell differentiation / Norrin signaling pathway / extracellular matrix-cell signaling / re-entry into mitotic cell cycle / retinal blood vessel morphogenesis / retinal rod cell differentiation / ubiquitin-dependent endocytosis / glycine metabolic process / retina layer formation ...retina blood vessel maintenance / cone retinal bipolar cell differentiation / Norrin signaling pathway / extracellular matrix-cell signaling / re-entry into mitotic cell cycle / retinal blood vessel morphogenesis / retinal rod cell differentiation / ubiquitin-dependent endocytosis / glycine metabolic process / retina layer formation / retinal pigment epithelium development / endothelial cell differentiation / microglial cell proliferation / dendritic spine development / establishment of blood-retinal barrier / vacuole organization / protein targeting to lysosome / microglia differentiation / establishment of blood-brain barrier / optic nerve development / frizzled binding / retinal ganglion cell axon guidance / lens development in camera-type eye / smoothened signaling pathway / exploration behavior / decidualization / action potential / blood vessel remodeling / canonical Wnt signaling pathway / response to axon injury / tricarboxylic acid cycle / visual perception / glutathione metabolic process / transforming growth factor beta receptor signaling pathway / cytokine activity / nervous system development / mitotic cell cycle / : / neuron apoptotic process / angiogenesis / cellular response to hypoxia / transcription by RNA polymerase II / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / protein ubiquitination / inflammatory response / positive regulation of DNA-templated transcription / cell surface / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / extracellular space類似検索 - 分子機能 Norrie disease protein / Glycoprotein hormone subunit beta / Cystine-knot domain / C-terminal cystine knot signature. / C-terminal cystine knot domain profile. / Cystine knot, C-terminal / C-terminal cystine knot-like domain (CTCK) / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine ...Norrie disease protein / Glycoprotein hormone subunit beta / Cystine-knot domain / C-terminal cystine knot signature. / C-terminal cystine knot domain profile. / Cystine knot, C-terminal / C-terminal cystine knot-like domain (CTCK) / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine / Ribbon / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Chang, T.-H. / Hsieh, F.-L. / Harlos, K. / Jones, E.Y. |
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資金援助 | 英国, 3件 組織 | 認可番号 | 国 |
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Medical Research Council (United Kingdom) | G0900084 | 英国 | Cancer Research UK | C375/A10976 | 英国 | Wellcome Trust | 090532/Z/09/Z | 英国 |
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引用 | ジャーナル: Elife / 年: 2015 タイトル: Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. 著者: Chang, T.H. / Hsieh, F.L. / Zebisch, M. / Harlos, K. / Elegheert, J. / Jones, E.Y. |
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履歴 | 登録 | 2015年5月28日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2015年7月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年7月22日 | Group: Database references |
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改定 1.2 | 2015年7月29日 | Group: Database references |
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改定 1.3 | 2017年9月13日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2024年1月10日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.5 | 2024年11月6日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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