Entry Database : PDB / ID : 4zbn Structure visualization Downloads & linksTitle Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor ComponentsBeta-nerve growth factor DNA (28-MER) DetailsKeywords Immune system/DNA / Complex / Aptamer / Immune system-DNA complexFunction / homology Function and homology informationFunction Domain/homology Component
NFG and proNGF binds to p75NTR / Ceramide signalling / nerve growth factor receptor binding / NGF processing / TRKA activation by NGF / PLC-gamma1 signalling / Signalling to STAT3 / p75NTR negatively regulates cell cycle via SC1 / metalloendopeptidase inhibitor activity / nerve growth factor signaling pathway ... NFG and proNGF binds to p75NTR / Ceramide signalling / nerve growth factor receptor binding / NGF processing / TRKA activation by NGF / PLC-gamma1 signalling / Signalling to STAT3 / p75NTR negatively regulates cell cycle via SC1 / metalloendopeptidase inhibitor activity / nerve growth factor signaling pathway / nerve development / Retrograde neurotrophin signalling / Axonal growth stimulation / NADE modulates death signalling / Signalling to p38 via RIT and RIN / ARMS-mediated activation / positive regulation of Ras protein signal transduction / PI3K/AKT activation / Frs2-mediated activation / positive regulation of DNA binding / NRAGE signals death through JNK / extrinsic apoptotic signaling pathway via death domain receptors / Signalling to RAS / cell surface receptor protein tyrosine kinase signaling pathway / p75NTR recruits signalling complexes / positive regulation of neuron differentiation / NF-kB is activated and signals survival / NRIF signals cell death from the nucleus / neuron projection morphogenesis / endosome lumen / growth factor activity / modulation of chemical synaptic transmission / Golgi lumen / synaptic vesicle / positive regulation of peptidyl-serine phosphorylation / negative regulation of neuron apoptotic process / negative regulation of cell population proliferation / axon / lipid binding / dendrite / positive regulation of gene expression / extracellular space / extracellular region / cytosol Similarity search - Function Nerve growth factor, beta subunit, mammalian / Nerve growth factor, beta subunit / Nerve growth factor family profile. / Nerve growth factor-related / Nerve growth factor conserved site / Nerve growth factor-like / Nerve growth factor family / Nerve growth factor family signature. / Nerve growth factor (NGF or beta-NGF) / Cystine Knot Cytokines, subunit B ... Nerve growth factor, beta subunit, mammalian / Nerve growth factor, beta subunit / Nerve growth factor family profile. / Nerve growth factor-related / Nerve growth factor conserved site / Nerve growth factor-like / Nerve growth factor family / Nerve growth factor family signature. / Nerve growth factor (NGF or beta-NGF) / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine / Ribbon / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)synthetic construct (others) Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.447 Å DetailsAuthors Davies, D.R. / Edwards, T.E. CitationJournal : Structure / Year : 2015Title : Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor.Authors: Jarvis, T.C. / Davies, D.R. / Hisaminato, A. / Resnicow, D.I. / Gupta, S. / Waugh, S.M. / Nagabukuro, A. / Wadatsu, T. / Hishigaki, H. / Gawande, B. / Zhang, C. / Wolk, S.K. / Mayfield, W.S. ... Authors : Jarvis, T.C. / Davies, D.R. / Hisaminato, A. / Resnicow, D.I. / Gupta, S. / Waugh, S.M. / Nagabukuro, A. / Wadatsu, T. / Hishigaki, H. / Gawande, B. / Zhang, C. / Wolk, S.K. / Mayfield, W.S. / Nakaishi, Y. / Burgin, A.B. / Stewart, L.J. / Edwards, T.E. / Gelinas, A.D. / Schneider, D.J. / Janjic, N. History Deposition Apr 15, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 10, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Jun 17, 2015 Group : Database referencesRevision 1.2 Jul 15, 2015 Group : Database references
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