Entry Database : PDB / ID : 4wnk Structure visualization Downloads & linksTitle Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022 ComponentsG protein-coupled receptor kinase 5 Details Keywords LIGASE / G protein-coupled receptor kinase 5 / hydrolase / phosphorylation / cardiovascular diseaseFunction / homology Function and homology informationFunction Domain/homology Component
G-protein-coupled receptor kinase / beta-adrenergic receptor kinase activity / G protein-coupled receptor kinase activity / tachykinin receptor signaling pathway / G alpha (s) signalling events / fat cell differentiation / Wnt signaling pathway / nuclear membrane / protein autophosphorylation / regulation of cell cycle ... G-protein-coupled receptor kinase / beta-adrenergic receptor kinase activity / G protein-coupled receptor kinase activity / tachykinin receptor signaling pathway / G alpha (s) signalling events / fat cell differentiation / Wnt signaling pathway / nuclear membrane / protein autophosphorylation / regulation of cell cycle / nuclear speck / protein serine/threonine kinase activity / lipid binding / apoptotic process / positive regulation of cell population proliferation / negative regulation of apoptotic process / ATP binding / plasma membrane / cytosol Similarity search - Function GPCR kinase / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / Regulator of G protein signaling domain / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal ... GPCR kinase / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / Regulator of G protein signaling domain / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Bos taurus (cattle)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.42 Å DetailsAuthors Homan, K.T. / Tesmer, J.J.G. Funding support United States, 3items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) HL071818 United States National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) HL086865 United States American Heart Association N014938 United States
CitationJournal : J.Biol.Chem. / Year : 2015Title : Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.Authors : Homan, K.T. / Waldschmidt, H.V. / Glukhova, A. / Cannavo, A. / Song, J. / Cheung, J.Y. / Koch, W.J. / Larsen, S.D. / Tesmer, J.J. History Deposition Oct 13, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 10, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Jun 17, 2015 Group : Database referencesRevision 1.2 Sep 2, 2015 Group : Database referencesRevision 1.3 Sep 6, 2017 Group : Author supporting evidence / Database references / Derived calculationsCategory : citation / pdbx_audit_support / pdbx_struct_oper_listItem : _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.4 Nov 1, 2017 Group : Author supporting evidence / Refinement description / Category : pdbx_struct_assembly_auth_evidence / softwareRevision 1.5 Dec 4, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.6 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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