Entry Database : PDB / ID : 4txy Structure visualization Downloads & linksTitle Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog ComponentsCyclic AMP-GMP synthase Details Keywords TRANSFERASE / nucleotidyl transferase / cyclic nucleotide synthase / cGASFunction / homology Function and homology informationFunction Domain/homology Component
3',3'-cyclic GMP-AMP synthase activity / cyclic nucleotide biosynthetic process / diguanylate cyclase activity / negative regulation of chemotaxis / Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases / defense response to virus / GTP binding / ATP binding / metal ion binding Similarity search - FunctionBiological species Vibrio cholerae O1 biovar El Tor str. N16961 (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 3.0001 Å DetailsAuthors Kranzusch, P.J. / Lee, A.S.Y. / Wilson, S.C. / Solovykh, M.S. / Vance, R.E. / Berger, J.M. / Doudna, J.A. Funding support United States, 2items Details Hide detailsOrganization Grant number Country Howard Hughes Medical Institute (HHMI) United States G. Harold and Leila Y. Mathers Foundation United States
CitationJournal : Cell / Year : 2014Title : Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.Authors : Kranzusch, P.J. / Lee, A.S. / Wilson, S.C. / Solovykh, M.S. / Vance, R.E. / Berger, J.M. / Doudna, J.A. History Deposition Jul 7, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 13, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Sep 3, 2014 Group : Database referencesRevision 1.2 Oct 1, 2014 Group : Database referencesRevision 1.3 Feb 4, 2015 Group : Derived calculationsRevision 1.4 Nov 20, 2019 Group : Author supporting evidence / Derived calculations ... Author supporting evidence / Derived calculations / Other / Source and taxonomy / Structure summary Category : entity_src_gen / pdbx_audit_support ... entity_src_gen / pdbx_audit_support / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_keywords Item : _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization ... _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation / _struct_keywords.text Revision 1.5 Dec 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / refine_hist Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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