Entry Database : PDB / ID : 4rma Structure visualization Downloads & linksTitle Crystal structure of the FERM domain of human ezrin ComponentsEzrin Details Keywords PEPTIDE BINDING PROTEIN / ERM / ezrin / FERM domain / membrane cytoskeleton linkersFunction / homology Function and homology informationFunction Domain/homology Component
terminal web assembly / intestinal D-glucose absorption / protein localization to cell cortex / establishment or maintenance of apical/basal cell polarity / regulation of microvillus length / regulation of organelle assembly / microvillus assembly / positive regulation of early endosome to late endosome transport / membrane to membrane docking / establishment of centrosome localization ... terminal web assembly / intestinal D-glucose absorption / protein localization to cell cortex / establishment or maintenance of apical/basal cell polarity / regulation of microvillus length / regulation of organelle assembly / microvillus assembly / positive regulation of early endosome to late endosome transport / membrane to membrane docking / establishment of centrosome localization / negative regulation of p38MAPK cascade / Netrin-1 signaling / cortical microtubule organization / uropod / astral microtubule organization / postsynaptic actin cytoskeleton organization / positive regulation of protein localization to early endosome / filopodium assembly / positive regulation of multicellular organism growth / protein-containing complex localization / establishment of endothelial barrier / sphingosine-1-phosphate receptor signaling pathway / S100 protein binding / Sensory processing of sound by outer hair cells of the cochlea / Sensory processing of sound by inner hair cells of the cochlea / protein kinase A binding / microvillus membrane / negative regulation of T cell receptor signaling pathway / leukocyte cell-cell adhesion / negative regulation of interleukin-2 production / cortical cytoskeleton / protein kinase A regulatory subunit binding / plasma membrane raft / protein kinase A catalytic subunit binding / Recycling pathway of L1 / brush border / microvillus / actin filament bundle assembly / immunological synapse / cellular response to cAMP / ruffle / cell adhesion molecule binding / protein kinase A signaling / ciliary basal body / filopodium / protein localization to plasma membrane / cell projection / cell periphery / actin filament / positive regulation of protein localization to plasma membrane / adherens junction / receptor internalization / negative regulation of ERK1 and ERK2 cascade / fibrillar center / ruffle membrane / positive regulation of protein catabolic process / disordered domain specific binding / actin filament binding / actin cytoskeleton / apical part of cell / actin binding / regulation of cell shape / ATPase binding / actin cytoskeleton organization / microtubule binding / basolateral plasma membrane / vesicle / endosome / cadherin binding / apical plasma membrane / protein domain specific binding / focal adhesion / positive regulation of gene expression / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / protein-containing complex / RNA binding / extracellular space / extracellular exosome / identical protein binding / membrane / plasma membrane / cytosol / cytoplasm Similarity search - Function Ezrin/radixin/moesin, alpha-helical domain / Ezrin/radixin/moesin, alpha-helical domain / Moesin tail domain superfamily / Ezrin/radixin/moesin / Ezrin/radixin/moesin, C-terminal / ERM family, FERM domain C-lobe / Ezrin/radixin/moesin family C terminal / Ezrin/radixin/moesin-like / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain ... Ezrin/radixin/moesin, alpha-helical domain / Ezrin/radixin/moesin, alpha-helical domain / Moesin tail domain superfamily / Ezrin/radixin/moesin / Ezrin/radixin/moesin, C-terminal / ERM family, FERM domain C-lobe / Ezrin/radixin/moesin family C terminal / Ezrin/radixin/moesin-like / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM, N-terminal / FERM N-terminal domain / FERM domain signature 1. / FERM conserved site / FERM domain signature 2. / FERM central domain / FERM/acyl-CoA-binding protein superfamily / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) / PH-like domain superfamily / Ubiquitin-like domain superfamily / Roll / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.75 Å DetailsAuthors Phang, J.M. / Harrop, S.J. / Duff, A.P. / Wilk, K.E. / Curmi, P.M.G. CitationJournal : Biochem. J. / Year : 2016Title : Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.Authors : Phang, J.M. / Harrop, S.J. / Duff, A.P. / Sokolova, A.V. / Crossett, B. / Walsh, J.C. / Beckham, S.A. / Nguyen, C.D. / Davies, R.B. / Glockner, C. / Bromley, E.H. / Wilk, K.E. / Curmi, P.M. History Deposition Oct 21, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 9, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Sep 27, 2017 Group : Database references / Refinement description / Category : citation / citation_author / softwareItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _software.name Revision 1.2 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less