- PDB-4ow8: Crystal structure of kinase domain of PknA from Mtb -
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Basic information
Entry
Database: PDB / ID: 4ow8
Title
Crystal structure of kinase domain of PknA from Mtb
Components
Serine/threonine-protein kinase PknA
Keywords
TRANSFERASE / PknA / kinase / drug target / Mtb
Function / homology
Function and homology information
biological process involved in interaction with host => GO:0051701 / peptidyl-threonine autophosphorylation / negative regulation of lipid biosynthetic process / negative regulation of catalytic activity / negative regulation of fatty acid biosynthetic process / positive regulation of catalytic activity / : / positive regulation of DNA binding / regulation of cell shape / protein autophosphorylation ...biological process involved in interaction with host => GO:0051701 / peptidyl-threonine autophosphorylation / negative regulation of lipid biosynthetic process / negative regulation of catalytic activity / negative regulation of fatty acid biosynthetic process / positive regulation of catalytic activity / : / positive regulation of DNA binding / regulation of cell shape / protein autophosphorylation / membrane => GO:0016020 / non-specific serine/threonine protein kinase / protein kinase activity / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / extracellular region / ATP binding / plasma membrane / cytosol Similarity search - Function
Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain ...Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homology
Resolution: 2.03→46.84 Å / Cor.coef. Fo:Fc: 0.906 / Cor.coef. Fo:Fc free: 0.868 / SU B: 6.247 / SU ML: 0.171 / Data cutoff high absF: 46.84 / Data cutoff low absF: 2.03 / Cross valid method: THROUGHOUT / ESU R: 0.266 / ESU R Free: 0.213 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.2749
791
5 %
RANDOM
Rwork
0.22601
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obs
0.22846
15124
99.82 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK