- PDB-4mwh: Crystal structure of scCK2 alpha in complex with ATP -
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Basic information
Entry
Database: PDB / ID: 4mwh
Title
Crystal structure of scCK2 alpha in complex with ATP
Components
Casein kinase II subunit alpha
Keywords
TRANSFERASE / Protein kinase / protein phosphorylation
Function / homology
Function and homology information
donor selection / Receptor Mediated Mitophagy / Regulation of TP53 Activity through Phosphorylation / Condensation of Prometaphase Chromosomes / regulation of ribosomal protein gene transcription by RNA polymerase II / CURI complex / UTP-C complex / regulation of transcription by RNA polymerase I / regulation of transcription by RNA polymerase III / protein kinase CK2 complex ...donor selection / Receptor Mediated Mitophagy / Regulation of TP53 Activity through Phosphorylation / Condensation of Prometaphase Chromosomes / regulation of ribosomal protein gene transcription by RNA polymerase II / CURI complex / UTP-C complex / regulation of transcription by RNA polymerase I / regulation of transcription by RNA polymerase III / protein kinase CK2 complex / Regulation of PTEN stability and activity / nucleolar large rRNA transcription by RNA polymerase I / maturation of SSU-rRNA / small-subunit processome / ribosomal small subunit assembly / regulation of cell cycle / non-specific serine/threonine protein kinase / protein kinase activity / protein serine kinase activity / protein serine/threonine kinase activity / DNA damage response / nucleolus / nucleoplasm / ATP binding / nucleus / cytosol Similarity search - Function
Casein Kinase 2, subunit alpha / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site ...Casein Kinase 2, subunit alpha / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homology
Method to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.09→34.91 Å / Cor.coef. Fo:Fc: 0.945 / Cor.coef. Fo:Fc free: 0.922 / SU B: 4.332 / SU ML: 0.118 / Cross valid method: THROUGHOUT / ESU R: 0.203 / ESU R Free: 0.179 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.24098
1452
5.1 %
RANDOM
Rwork
0.19639
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obs
0.19866
27225
99.61 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK