PDB-4ghl: Structural Basis for Marburg virus VP35 mediate immune evasion me...

ID or keywords:

Entry

Database: PDB / ID: 4ghl

Title

Structural Basis for Marburg virus VP35 mediate immune evasion mechanisms

Components

Polymerase cofactor VP35
short palindromic RNA AGACAGCAUAUGCUGUCU

Keywords

TRANSCRIPTION /

viral protein/RNA / protein-RNA complex / VP35 / IFN inhibitor /

RNA binding protein / Interferon antagonism / double stranded RNA /

viral protein-RNA complex

Function / homology

Function and homology information

virion component / host cell cytoplasm
Similarity search - Function

Biological species

Lake Victoria marburgvirus

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.02 Å

Authors

Ramanan, P. / Borek, D.M. / Otwinowski, Z. / Leung, D.W. / Amarasinghe, G.K.

Citation

Journal: Proc.Natl.Acad.Sci.USA / Year: 2012
Title: Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.
Authors: Ramanan, P. / Edwards, M.R. / Shabman, R.S. / Leung, D.W. / Endlich-Frazier, A.C. / Borek, D.M. / Otwinowski, Z. / Liu, G. / Huh, J. / Basler, C.F. / Amarasinghe, G.K.

History

Deposition	Aug 7, 2012	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Nov 28, 2012	Provider: repository / Type: Initial release
Revision 1.1	Dec 26, 2012	Group: Database references
Revision 1.2	Sep 13, 2023	Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ncs_dom_lim / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	4ghl.cif.gz	264.6 KB	Display	PDBx/mmCIF format
PDB format	pdb4ghl.ent.gz	212.5 KB	Display	PDB format
PDBx/mmJSON format	4ghl.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/gh/4ghl ftp://data.pdbj.org/pub/pdb/validation_reports/gh/4ghl	HTTPS FTP

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Related structure data

Related structure data	3fkeS 3l25 3l26 3l27 3l28 3l29 S: Starting model for refinement
Similar structure data	5jbs-d 6i3p-4 4p4d-d 3of6-1 2pvw-d 6hyt-3 6okd-1 6h7y-d Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#121 - Jan 2010 70S Ribosomes similarity (1) #130 - Oct 2010 Riboswitches similarity (1) #16 - Apr 2001 Aminoacyl-tRNA Synthetases similarity (1) #157 - Jan 2013 Transfer-Messenger RNA similarity (1) #229 - Jan 2019 Fluorescent RNA Aptamers similarity (1) #181 - Jan 2015 Cascade and CRISPR similarity (1) #253 - Jan 2021 Expressome similarity (1) #260 - Aug 2021 Ribonuclease P similarity (1) #249 - Sep 2020 SARS-CoV-2 RNA-dependent RNA Polymerase similarity (1) #15 - Mar 2001 Transfer RNA similarity (1) #146 - Feb 2012 Aminoglycoside Antibiotics similarity (1) #210 - Jun 2017 Adenine Riboswitch in Action similarity (1) #10 - Oct 2000 Ribosome similarity (1) #87 - Mar 2007 Zinc Fingers similarity (1) #245 - May 2020 Spliceosomes similarity (1) #262 - Oct 2021 Fifty Years of Open Access to PDB Structures similarity (1) #65 - May 2005 Self-splicing RNA similarity (1) #98 - Feb 2008 Small Interfering RNA similarity (1) #226 - Oct 2018 Aminoglycoside Antibiotics and Resistance similarity (1) #105 - Sep 2008 Ribonuclease A similarity (1) #178 - Oct 2014 Ebola Virus Proteins similarity (6) #230 - Feb 2019 Initiation Factor eIF4E similarity (1) #227 - Nov 2018 Telomerase similarity (1) #161 - May 2013 Ricin similarity (1) #143 - Nov 2011 Toll-like Receptors similarity (1) #106 - Oct 2008 Poly(A) Polymerase similarity (1) #266 - Feb 2022 Oligosaccharyltransferase similarity (1) #81 - Sep 2006 Elongation Factors similarity (1) #104 - Aug 2008 Selenocysteine Synthase similarity (1) #89 - May 2007 Aconitase and Iron Regulatory Protein 1 similarity (1) #241 - Jan 2020 Twenty Years of Molecules similarity (1)

PDB pages

PDBj /

wwPDB /

NCBI

Related items in Molecule of the Month

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Deposited unit

E: short palindromic RNA AGACAGCAUAUGCUGUCU

F: short palindromic RNA AGACAGCAUAUGCUGUCU

A: Polymerase cofactor VP35

B: Polymerase cofactor VP35

C: Polymerase cofactor VP35

D: Polymerase cofactor VP35

hetero molecules

70.7 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

C: Polymerase cofactor VP35

hetero molecules

B: Polymerase cofactor VP35

hetero molecules

A: Polymerase cofactor VP35

hetero molecules

E: short palindromic RNA AGACAGCAUAUGCUGUCU

F: short palindromic RNA AGACAGCAUAUGCUGUCU

D: Polymerase cofactor VP35

hetero molecules

defined by software
70.7 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Type	Name	Symmetry operation	Number
crystal symmetry operation	2_455	-x-1/2,-y,z+1/2	1
crystal symmetry operation	3_544	-x,y-1/2,-z-1/2	1
crystal symmetry operation	4_455	x-1/2,-y+1/2,-z	1
identity operation	1_555	x,y,z	1

Unit cell

Length a, b, c (Å)	83.771, 93.384, 102.071
Angle α, β, γ (deg.)	90.00, 90.00, 90.00
Int Tables number	19
Space group name H-M	P2₁2₁2₁

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID	Details
1	1	E
2	1	F
1	2	A
2	2	B
1	3	A
2	3	C
1	4	A
2	4	D
1	5	B
2	5	C
1	6	B
2	6	D
1	7	C
2	7	D

NCS domain segments:

Component-ID: 0 / Refine code: 0

Dom-ID	Ens-ID	Beg auth comp-ID	Beg label comp-ID	End auth comp-ID	End label comp-ID	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	A	A	U	U	E	A	1 - 18	1 - 18
2	1	A	A	U	U	F	B	1 - 18	1 - 18
1	2	LEU	LEU	LYS	LYS	A	C	208 - 328	12 - 132
2	2	LEU	LEU	LYS	LYS	B	D	208 - 328	12 - 132
1	3	LEU	LEU	LYS	LYS	A	C	208 - 328	12 - 132
2	3	LEU	LEU	LYS	LYS	C	E	208 - 328	12 - 132
1	4	LEU	LEU	LYS	LYS	A	C	208 - 328	12 - 132
2	4	LEU	LEU	LYS	LYS	D	F	208 - 328	12 - 132
1	5	LEU	LEU	ILE	ILE	B	D	208 - 329	12 - 133
2	5	LEU	LEU	ILE	ILE	C	E	208 - 329	12 - 133
1	6	LEU	LEU	ILE	ILE	B	D	208 - 329	12 - 133
2	6	LEU	LEU	ILE	ILE	D	F	208 - 329	12 - 133
1	7	LEU	LEU	ILE	ILE	C	E	208 - 329	12 - 133
2	7	LEU	LEU	ILE	ILE	D	F	208 - 329	12 - 133

NCS ensembles :

ID
1
2
3
4
5
6
7

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RNA chain / Protein , 2 types, 6 molecules EFABCD

#1: RNA chain	short palindromic RNA AGACAGCAUAUGCUGUCU Mass: 5733.451 Da / Num. of mol.: 2 / Source method: obtained synthetically / Details: IDT DNA
#2: Protein	Polymerase cofactor VP35 Mass: 14638.870 Da / Num. of mol.: 4 / Fragment: UNP residues 200-329 / Mutation: L277A Source method: isolated from a genetically manipulated source Source: (gene. exp.) Lake Victoria marburgvirus / Strain: Popp-67 / Gene: Polymerase cofactor VP35, VP35 / Plasmid: pET15 / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: Q03039

#1: RNA chain

short palindromic RNA AGACAGCAUAUGCUGUCU

Mass: 5733.451 Da / Num. of mol.: 2 / Source method: obtained synthetically / Details: IDT DNA

#2: Protein

Polymerase cofactor VP35

Mass: 14638.870 Da / Num. of mol.: 4 / Fragment: UNP residues 200-329 / Mutation: L277A
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Lake Victoria marburgvirus / Strain: Popp-67 / Gene: Polymerase cofactor VP35, VP35 / Plasmid: pET15 / Production host:

Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: Q03039

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Non-polymers , 4 types, 398 molecules

#3: Chemical	ChemComp-MG / MAGNESIUM ION Mass: 24.305 Da / Num. of mol.: 11 / Source method: obtained synthetically / Formula: Mg
#4: Chemical	ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL / Ethylene glycol Mass: 62.068 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₂H₆O₂
#5: Chemical	ChemComp-CL / CHLORIDE ION / Chloride Mass: 35.453 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: Cl
#6: Water	ChemComp-HOH / water / Water Mass: 18.015 Da / Num. of mol.: 379 / Source method: isolated from a natural source / Formula: H₂O

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.85 Å³/Da / Density % sol: 56.85 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 6 Details: 0.1M sodium citrate (pH 5.5), 0.1M sodium citrate (pH 6.0), 0.25% glycerol, 14% PEG 6000 and 0.6M ammonium sulfate., VAPOR DIFFUSION, HANGING DROP, temperature 293K

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Data collection

Diffraction	Mean temperature: 100 K
Diffraction source	Source: SYNCHROTRON / Site: APS / Beamline: 19-ID / Wavelength: 0.9793376 Å
Detector	Type: ADSC QUANTUM 315r / Detector: CCD / Date: Aug 3, 2011
Radiation	Monochromator: Rosenbaum-Rock high-resolution double-crystal monochromator. LN2 cooled first crystal, sagittal focusing 2nd crystal Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.9793376 Å / Relative weight: 1
Reflection	Resolution: 2.01→50 Å / % possible obs: 100 % / Observed criterion σ(F): 0 / Observed criterion σ(I): 0 / R_merge(I) obs: 0.094 / Net I/σ(I): 22.9
Reflection shell	Resolution: 2.01→2.04 Å / Redundancy: 7.2 % / R_merge(I) obs: 0.928 / Mean I/σ(I) obs: 2.6 / Num. unique all: 2577 / R_sym value: 0.928 / % possible all: 100

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Processing

Software

Name	Version	Classification
HKL-3000		data collection
MOLREP		phasing
REFMAC	5.6.0117	refinement
HKL-3000		data reduction
SCALEPACK		data scaling

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: PDB ENTRY 3FKE

3fke

Resolution: 2.02→37.87 Å / Cor.coef. F_o:F_c: 0.95 / Cor.coef. F_o:F_c free: 0.919 / SU B: 7.482 / SU ML: 0.108 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.165 / ESU R Free: 0.161 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT

	R_factor	Num. reflection	% reflection	Selection details
R_free	0.23994	2577	5 %	RANDOM
R_work	0.18731	-	-	-
all	0.18999	48487	-	-
obs	0.18999	48487	95.57 %	-

Solvent computation

Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK

Displacement parameters

B_iso mean: 30.18 Å²

	B_aniso -1	B_aniso -2	B_aniso -3
1-	-0.01 Å²	0 Å²	0 Å²
2-	-	0 Å²	0 Å²
3-	-	-	0.01 Å²

Refinement step

Cycle: LAST / Resolution: 2.02→37.87 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	3856	758	31	379	5024

Refine LS restraints

Refine-ID	Type	Dev ideal	Dev ideal target	Number
X-RAY DIFFRACTION	r_bond_refined_d	0.011	0.018	4832
X-RAY DIFFRACTION	r_angle_refined_deg	1.496	1.876	6724
X-RAY DIFFRACTION	r_dihedral_angle_1_deg	5.412	5	499
X-RAY DIFFRACTION	r_dihedral_angle_2_deg	37.856	23.544	158
X-RAY DIFFRACTION	r_dihedral_angle_3_deg	13.866	15	669
X-RAY DIFFRACTION	r_dihedral_angle_4_deg	11.617	15	24
X-RAY DIFFRACTION	r_chiral_restr	0.093	0.2	762
X-RAY DIFFRACTION	r_gen_planes_refined	0.008	0.021	3361

Refine LS restraints NCS

Refine-ID: X-RAY DIFFRACTION / Type: interatomic distance / Weight position: 0.05

Ens-ID	Dom-ID	Auth asym-ID	Number	Rms dev position (Å)
1	1	E	110	0.1
1	2	F	110	0.1
2	1	A	136	0.03
2	2	B	136	0.03
3	1	A	138	0.05
3	2	C	138	0.05
4	1	A	137	0.02
4	2	D	137	0.02
5	1	B	139	0.08
5	2	C	139	0.08
6	1	B	139	0.02
6	2	D	139	0.02
7	1	C	139	0.08
7	2	D	139	0.08

LS refinement shell

Resolution: 2.017→2.069 Å / Total num. of bins used: 20

	R_factor	Num. reflection	% reflection
R_free	0.275	114	-
R_work	0.208	1772	-
obs	-	-	48.58 %

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	10.2	-2.5247	-0.4509	8.3677	-4.6724	12.6887	-0.1023	0.2948	-0.2946	-0.559	0.239	0.6598	0.3686	-0.81	-0.1368	0.1617	-0.0297	0.0172	0.1478	-0.0047	0.1778	-14.144	72.785	-7.57
2	1.4708	-3.3852	1.0179	12.4256	-0.2098	1.6911	-0.2427	-0.0443	0.1319	0.5093	0.0263	-0.0748	-0.2026	-0.0903	0.2164	0.2886	-0.0048	0.0749	0.2085	-0.0861	0.3246	-10.804	59.567	-5.39
3	13.4777	7.0834	-5.4613	10.1654	-3.6934	2.6058	-0.0642	0.2964	0.0621	-0.1273	0.0127	0.5045	0.0135	-0.3247	0.0516	0.1115	0.0198	-0.0009	0.2242	-0.0696	0.1529	-4.781	52.823	-10.519
4	0.7992	-0.3531	1.3893	1.7261	-1.1266	2.5832	-0.0357	0.0017	0.0072	-0.0689	0.0468	0.0622	-0.0405	-0.009	-0.0111	0.0891	0.0123	-0.0016	0.0917	0.0089	0.105	5.254	53.759	-11.158
5	2.7587	-1.8334	-2.1774	8.6146	-3.9721	11.5071	-0.0027	0.2457	0.0675	-0.371	-0.0288	0.2323	0.0292	-0.2418	0.0315	0.0741	0.0036	-0.0047	0.0673	0.0061	0.1045	8.143	45.721	-11.949
6	5.0414	0.0299	-3.6801	1.8312	-2.3	5.5263	0.0309	0.2234	-0.0892	-0.0217	0.0103	0.1034	0.003	-0.164	-0.0411	0.1067	0.0223	-0.0178	0.0734	0.0074	0.1243	1.913	45.237	-8.233
7	10.0532	-5.0162	-3.5581	6.8178	-0.9155	2.9387	-0.0164	0.2888	-0.2574	-0.1129	0.1232	0.4567	0.0911	-0.2654	-0.1067	0.1109	-0.0047	0.0215	0.1146	-0.0079	0.1503	-7.376	46.483	-2.737
8	6.1104	3.82	1.861	4.9006	-0.4326	1.6494	-0.1611	-0.3236	0.2037	-0.0545	0.0259	0.1753	-0.0555	-0.1965	0.1352	0.0824	0.0271	0.061	0.1267	0.0195	0.2044	-6.454	53.295	0.947
9	8.4642	3.5127	-0.6886	3.8611	-0.3338	5.7528	-0.1168	0.0552	0.4615	0.389	0.0798	0.1611	-0.2416	-0.1515	0.037	0.1408	0.0463	0.0187	0.0579	-0.003	0.1078	2.086	58.97	0.686
10	2.1285	1.6305	-1.4435	6.1655	-0.883	0.9904	0.1851	-0.4581	-0.0589	0.3066	-0.2174	-0.0794	-0.1093	0.3138	0.0323	0.1744	0.019	-0.0379	0.2053	-0.0299	0.1155	9.696	59.1	-0.296
11	2.8194	0.9037	-1.4046	1.3829	-1.9287	3.1181	0.0089	-0.1597	0.0463	0.2238	-0.047	0.0337	-0.1459	-0.001	0.0381	0.134	0.007	0.0103	0.0873	-0.0088	0.1045	6.883	49.973	1.888
12	3.9019	4.7428	3.9675	22.1573	-8.5006	15.9438	0.0847	-0.3874	0.1122	0.7106	-0.0582	0.2098	-0.2841	-0.2401	-0.0265	0.1452	0.1111	0.0274	0.2924	-0.0251	0.1014	-2.114	47.135	6.028
13	0.4348	0.4113	1.1125	4.1975	7.0093	12.2061	-0.074	-0.0926	0.0444	0.0598	0.1032	-0.0386	-0.021	0.1219	-0.0292	0.1166	-0.0195	0.0021	0.1296	-0.001	0.1183	-1.901	36.046	-1.662
14	3.6233	2.7109	0.8224	5.0209	-0.7578	0.8168	-0.214	0.2699	-0.1524	-0.561	0.226	-0.162	0.1352	0.0495	-0.0119	0.1581	-0.0427	0.0419	0.1018	0.0016	0.0963	1.438	28.8	-14.995
15	19.5216	0.1882	0.0684	16.0265	7.2936	10.6579	-0.378	0.6978	0.1604	-0.7489	0.3629	-0.2643	-0.0156	0.3041	0.015	0.1178	0.0052	-0.0062	0.1175	0.0018	0.0534	7.895	35.287	-17.506
16	3.6743	0.2861	1.2801	2.3634	-2.1307	2.5753	-0.1097	0.2218	-0.1221	-0.0772	0.0403	-0.107	0.0205	0.0589	0.0695	0.1019	0.0128	-0.0009	0.1057	-0.0064	0.1033	12.082	36.703	-11.729
17	0.8834	0.2419	0.1202	2.4682	0.5548	1.4665	0.0139	-0.0776	0.0484	0.131	-0.0305	0.0286	0.0435	-0.0328	0.0165	0.0835	0.0011	-0.0137	0.0819	0.0169	0.1103	5.603	31.98	2.562
18	0.5708	0.3918	-0.0985	2.287	0.7077	0.3446	-0.0754	-0.0074	0.0446	0.0793	0.0833	0.0613	0.0127	-0.006	-0.0079	0.1285	0.0455	0.0027	0.1065	0.0161	0.1187	4.39	36.304	-2.196
19	5.492	5.4238	4.3587	11.1467	8.5495	20.5165	0.0764	0.3186	-0.5259	-0.0028	0.1564	-0.242	0.5933	0.342	-0.2329	0.0796	-0.0006	0.0152	0.1062	0	0.1153	1.927	23.482	-11.567
20	2.8082	0.0905	1.8875	4.6933	0.7318	2.2691	-0.0519	0.0089	-0.0052	-0.0244	0.203	-0.1678	-0.0404	-0.0189	-0.1512	0.0746	0.0116	0.0151	0.0893	-0.0011	0.0976	8.748	35.641	-4.773
21	15.4481	5.7892	-0.7687	10.8576	-6.3614	8.1857	-0.0283	-0.3897	0.3693	0.4111	0.0701	0.8492	-0.5402	-0.7101	-0.0418	0.1264	0.0643	-0.0524	0.3875	-0.1228	0.2323	-12.836	46.81	-38.902
22	7.3455	-1.8185	-3.3398	9.3549	-1.0097	1.8977	0.1353	0.3451	-0.177	0.0853	-0.1788	0.2554	-0.0876	-0.1375	0.0435	0.1452	0.0206	-0.0375	0.1106	-0.0438	0.1393	-4.999	49.038	-42.248
23	2.9889	-3.181	-0.8758	6.0748	0.4776	0.3366	0.1275	0.1017	0.006	-0.1986	-0.1378	0.021	-0.0243	-0.0196	0.0102	0.1198	-0.0195	-0.0046	0.0755	0.0094	0.1001	2.753	47.275	-44.574
24	0.7509	-1.0254	0.963	4.8977	-2.2384	1.4791	0.065	0.0861	0.0203	0.1656	-0.145	-0.2279	0.0164	0.1147	0.0799	0.1176	-0.0234	0.0009	0.0826	0.0059	0.1066	1.479	42.673	-40.007
25	6.177	1.8963	-2.4183	3.7871	-1.5473	1.1496	0.007	-0.0127	-0.0958	-0.1501	0.0074	0.2052	0.0369	0.0052	-0.0144	0.1168	-0.0241	-0.007	0.0936	-0.0077	0.1115	-6.28	40.416	-35.834
26	6.6772	3.2728	-3.842	16.009	0.9353	5.518	0.0159	-0.0387	0.0329	-0.2102	-0.0966	0.4475	-0.1323	-0.4809	0.0808	0.1171	0.0049	0.0112	0.1807	-0.0066	0.1558	-13.007	43.222	-30.767
27	5.0838	2.2954	5.7762	6.5254	0.8552	9.1086	0.0604	-0.0888	0.2538	-0.0522	-0.0583	0.344	-0.1998	-0.123	-0.002	0.1425	-0.015	0.0293	0.0688	-0.0067	0.1136	-7.328	51.424	-30.521
28	9.5206	2.6458	-0.9068	5.3859	1.4853	0.7364	0.2261	0.0657	0.0922	0.2288	-0.2242	0.0194	0.037	-0.1025	-0.0018	0.2205	0.0298	-0.0124	0.1267	-0.0413	0.0884	-0.989	55.521	-31.829
29	1.2835	-0.0199	-0.311	14.9685	12.1814	10.031	-0.0304	-0.3092	0.0118	0.4598	0.3441	-0.4188	0.3477	0.4249	-0.3138	0.1277	-0.0153	-0.0067	0.1971	0.0528	0.1178	5.105	56.381	-32.222
30	1.7621	1.1077	-1.5211	1.9784	-4.0565	8.8353	-0.0655	-0.2044	0.1141	0.0816	-0.1969	-0.0699	-0.1959	0.3657	0.2624	0.1482	-0.0076	0.0039	0.1026	-0.0023	0.111	4.556	48.258	-32.376
31	5.7029	3.3598	-4.7102	3.4764	-0.8277	6.4369	0.2091	-0.2989	-0.0621	0.2283	-0.372	0.0567	-0.0697	0.0101	0.1629	0.1656	-0.0511	-0.0002	0.0725	-0.0175	0.0909	-1.182	44.572	-25.507
32	1.6604	-1.1113	-0.6631	4.1745	0.8184	2.791	0.0357	-0.1592	0.0787	0.2754	-0.0477	0.1054	-0.037	0.0275	0.0119	0.1296	-0.0225	0.0052	0.0662	-0.0105	0.0957	-3.496	37.452	-26.477
33	0.2828	-0.523	-0.204	3.8846	4.3468	14.0667	-0.0627	0.1508	-0.0601	-0.1443	-0.0926	0.2446	0.1765	-0.1978	0.1553	0.1109	-0.0362	0.007	0.1507	-0.0064	0.1183	-3.831	29.194	-38.568
34	7.5455	2.346	-1.4284	8.8588	-2.5115	5.1818	-0.2929	0.436	-0.0867	-0.3713	0.0954	-0.1823	0.1821	-0.0891	0.1975	0.1139	-0.0167	0.0226	0.0976	-0.0259	0.093	2.762	26.348	-48.766
35	2.5814	2.1401	0.9806	2.5843	-0.1285	2.8277	-0.1244	0.1528	-0.1489	-0.3831	0.1275	0.033	-0.015	0.1822	-0.0031	0.2251	-0.0215	-0.0344	0.0737	0.0045	0.1511	8.033	35.08	-47.425
36	0.3161	-0.6881	-0.8032	6.057	-1.8487	4.9172	-0.0076	-0.0407	0.0525	0.0065	-0.1227	-0.4737	-0.026	0.2674	0.1303	0.1029	-0.0193	-0.0166	0.0994	0.0155	0.1276	9.094	29.67	-36.341
37	2.3751	-2.3744	-0.535	9.5023	0.1606	3.7924	-0.0717	-0.2297	-0.0985	0.5097	0.0697	-0.214	0.1618	0.2047	0.0019	0.1042	-0.0203	-0.0043	0.1195	0.0061	0.0959	2.866	32.026	-27.127
38	1.7223	1.0363	0.8428	4.8897	0.4626	5.6877	-0.0227	0.0731	-0.0445	0.1248	0.1524	-0.0813	-0.1992	0.2809	-0.1296	0.1003	-0.0038	0.0178	0.0641	0.0015	0.0849	3.956	33.956	-32.664
39	3.6494	3.6629	1.1545	8.9367	3.5024	1.4409	-0.2355	0.2288	-0.4281	-0.597	0.3206	-0.4685	-0.1957	0.0722	-0.0851	0.1724	-0.1339	0.1011	0.1657	-0.07	0.2102	0.576	22.661	-44.011
40	3.5319	0.7134	-3.0801	1.3559	-1.3902	3.1804	-0.3121	0.1886	-0.0444	0.1356	0.1881	-0.1177	0.1488	-0.2318	0.124	0.1092	-0.013	-0.0045	0.1764	-0.0139	0.1533	6.53	29.978	-37.93
41	4.317	4.1066	-2.8059	19.1548	-0.6062	6.3117	-0.0273	0.1684	0.5725	-0.1494	0.1505	0.5914	-0.5597	-0.3957	-0.1231	0.1407	0.027	-0.0096	0.2479	-0.0595	0.1675	-31.423	29.587	-33.435
42	4.4668	-0.5203	2.035	2.003	-4.0155	8.3682	0.0965	-0.1473	-0.1923	0.0722	0.1903	0.11	-0.1063	-0.5408	-0.2868	0.0314	-0.0414	0.013	0.4039	-0.0543	0.0805	-31.971	18.315	-30.671
43	7.9723	-0.7095	-2.9434	4.3089	1.795	12.2197	-0.053	-0.3431	0.1451	0.3338	-0.0434	0.2468	0.0904	-0.1498	0.0964	0.1113	-0.0311	0.0095	0.1381	-0.013	0.1334	-23.966	15.909	-29.997
44	3.0398	0.4059	-0.6785	3.9215	-4.3086	6.1828	-0.0086	-0.1758	0.1071	0.2107	-0.1317	-0.1036	-0.0782	-0.2983	0.1404	0.1064	-0.0339	-0.0198	0.1899	-0.0579	0.0927	-23.316	21.95	-34.201
45	6.8063	-4.5232	0.4596	16.0689	-1.3641	7.7374	-0.165	-0.3913	0.9331	0.3387	0.1016	-0.1696	-0.7422	0.028	0.0634	0.1343	0.0136	-0.0335	0.1908	-0.0352	0.1838	-24.825	31.035	-39.88
46	10.4705	9.75	-2.7683	10.5312	-0.9292	2.6361	0.1493	0.0826	-0.0424	-0.1187	-0.1191	-0.157	-0.3431	-0.2761	-0.0302	0.1422	0.0758	-0.0638	0.2676	0.0441	0.3875	-31.787	29.671	-43.324
47	12.3292	3.0097	6.4572	9.8936	-2.0233	7.9892	-0.1209	0.0539	0.3891	-0.0142	0.0121	0.3822	-0.3612	-0.6414	0.1089	0.1217	0.0086	-0.0185	0.222	-0.0374	0.1314	-37.499	22.224	-42.208
48	4.7638	1.7431	0.5103	13.6597	-4.6696	13.96	0.1225	0.1299	-0.5072	-0.4559	-0.0163	0.1818	0.4597	-0.7222	-0.1063	0.1516	-0.0457	-0.0203	0.2498	-0.0759	0.1821	-38.568	14.559	-42.934
49	1.8429	1.0535	1.6743	2.8196	-1.457	4.2179	0.0428	-0.1186	0.1822	0.1556	0.0048	0.324	-0.0363	-0.2834	-0.0476	0.1043	-0.0866	0.0553	0.1712	-0.0856	0.1511	-30.741	14.507	-39.134
50	4.5853	1.4677	0.7111	6.1891	-2.2331	4.3761	0.0698	-0.1198	-0.2549	-0.2656	-0.1825	0.0008	-0.0696	0.0316	0.1128	0.0904	-0.0243	-0.0005	0.1161	-0.0573	0.1028	-27.679	17.102	-46.116
51	8.3449	-0.4502	1.5861	8.6402	4.3859	2.6346	-0.1184	0.467	0.508	-0.1978	-0.1217	0.2042	-0.1579	0.0105	0.2401	0.1521	0.0165	-0.0389	0.1832	-0.0064	0.1116	-26.883	24.833	-48.332
52	1.4933	-1.5774	2.7799	4.9925	1.1921	13.1604	-0.0238	0.135	0.096	-0.5326	-0.273	0.2698	-0.2031	-0.3036	0.2968	0.2446	-0.0402	-0.0593	0.1545	0.0273	0.1877	-17.288	24.98	-45.504
53	1.9274	-1.151	-1.0359	4.1256	-0.7689	1.1207	-0.045	-0.0728	-0.0268	0.1719	0.1138	0.2633	-0.0317	0.0145	-0.0688	0.109	-0.0399	-0.0068	0.0709	0.0036	0.1209	-8.948	25.301	-29.239
54	8.7769	1.0024	-3.6233	3.3553	0.1336	6.5037	-0.0432	-0.3567	-0.0601	0.2502	0.013	0.0507	0.0815	-0.0573	0.0301	0.1103	-0.0195	-0.0013	0.0718	-0.0022	0.0978	-10.483	18.14	-26.326
55	9.5061	-0.1345	-3.9934	7.6512	7.434	10.2408	0.0347	-0.5366	-0.309	0.5855	0.0087	-0.0708	0.7079	0.1404	-0.0433	0.0997	-0.0326	-0.0168	0.0904	0.0226	0.0958	-15.282	12.078	-28.246
56	0.2404	0.2346	0.7039	0.2352	0.6784	2.1749	0.0128	0.0148	-0.0315	0.0054	-0.0048	-0.0423	-0.0453	0.0807	-0.0079	0.1511	-0.0153	0.0069	0.1131	-0.0029	0.1338	-8.573	15.411	-40.67
57	12.6529	1.4682	-2.6809	4.9488	-0.6061	2.4554	-0.0892	0.4794	-0.0833	-0.3272	0.0669	0.0961	0.0301	-0.173	0.0222	0.1502	-0.0004	-0.0145	0.127	-0.0021	0.1025	-15.868	19.415	-47.246
58	0.6732	1.0796	0.0483	1.7438	0.0673	0.0392	-0.0229	-0.0398	0.0623	-0.0548	-0.0374	0.0734	-0.0439	-0.0421	0.0603	0.141	0.0103	-0.0296	0.1281	-0.036	0.1366	-13.298	20.13	-37.741
59	12.7329	6.8833	11.991	8.2881	10.6093	22.6377	0.1338	-0.0642	-0.3346	0.6282	0.0506	-0.5816	0.7285	0.6919	-0.1844	0.1302	0.0012	-0.0141	0.0692	0.0204	0.1222	-1.885	22.91	-30.755
60	2.5601	1.5037	4.4607	3.4436	2.7117	7.7795	-0.0061	0.02	-0.0296	-0.2667	0.0297	0.0106	-0.0295	0.0244	-0.0236	0.1281	-0.0194	-0.0328	0.0945	-0.0644	0.1996	-13.646	15.353	-37.487
61	7.7415	0.7068	0.4967	13.7849	-2.1861	3.2149	-0.0376	-0.3703	0.766	0.1497	-0.1179	0.1989	-0.7551	-0.4166	0.1556	0.3937	0.2189	-0.0696	0.2272	-0.0976	0.2902	-22.623	33.069	-0.989
62	9.2193	3.0529	0.9842	7.4019	-3.3368	2.2096	-0.1831	0.1392	0.444	0.1201	0.0155	-0.0833	-0.1023	0.0254	0.1676	0.1411	0.0179	-0.0168	0.1014	0.0185	0.1356	-23.847	24.278	1.19
63	9.8293	-4.7072	2.7397	3.1369	-1.8107	1.405	-0.1076	-0.3214	0.1548	0.166	0.0514	-0.0218	-0.0888	0.0038	0.0563	0.1176	-0.0146	0.0046	0.0874	0.006	0.0987	-21.778	16.33	3.902
64	4.8568	-1.1545	-0.6634	0.4109	-0.4942	3.2971	-0.0684	0.1025	0.0002	0.0171	-0.0133	-0.0112	0.0396	0.0259	0.0817	0.0817	0.0092	0.0036	0.1045	0.018	0.1015	-16.385	17.331	-0.905
65	6.5026	2.3129	-0.8017	6.8186	0.1637	0.4193	-0.0541	0.152	0.6214	0.0023	0.1303	0.2143	0.1366	0.1878	-0.0761	0.1027	0.0471	-0.027	0.1842	0.0382	0.1491	-15.293	26.311	-5.431
66	18.4139	3.0536	-2.7802	7.7462	-5.6824	4.2469	0.0008	-0.3499	0.6805	-0.0791	0.0666	0.0396	-0.1009	-0.0039	-0.0675	0.4123	-0.0866	0.0156	0.142	0.0485	0.2237	-18.954	32.912	-10.21
67	3.0748	2.9927	-0.3176	10.2046	-3.584	4.8955	-0.1077	0.1767	0.4946	0.0937	-0.0294	0.179	-0.3945	-0.1934	0.137	0.0969	0.0072	-0.03	0.1289	0.0444	0.2092	-26.925	25.737	-9.302
68	9.215	1.8361	-4.4563	14.0965	1.0278	2.4256	0.0238	0.4136	0.2245	-0.3658	0.0566	0.3381	-0.0747	-0.1984	-0.0804	0.172	-0.0071	-0.0305	0.1177	0.0213	0.1108	-31.778	19.546	-9.488
69	16.3812	0.494	8.2626	1.6579	1.6295	6.0004	0.2722	0.4871	-0.1334	-0.3308	-0.1892	0.1658	0.146	-0.0689	-0.083	0.2514	-0.0325	-0.0672	0.1213	0.0362	0.1583	-28.302	13.255	-7.685
70	8.8799	0.7996	-3.0436	6.1278	-1.7094	7.1672	-0.0752	0.5289	0.2257	-0.134	0.124	0.2574	0.0164	-0.0445	-0.0488	0.0625	-0.0036	-0.0069	0.1013	0.0152	0.0757	-22.003	16.821	-10.896
71	1.59	0.8735	0.0236	9.0382	0.4631	2.7228	-0.1495	0.3919	0.2113	-0.2183	0.1523	-0.1174	-0.0322	-0.0383	-0.0029	0.056	-0.0287	-0.0152	0.1365	0.0556	0.0879	-18.838	22.229	-15.805
72	3.5261	1.8083	3.5768	3.1426	0.4372	4.5263	-0.0622	0.0471	0.1549	-0.296	-0.0868	0.0826	0.147	0.1027	0.149	0.1574	-0.0276	0.0191	0.0965	0.0086	0.1186	-8.179	23.489	-11.885
73	2.8402	-1.4302	-0.5804	4.3786	-0.326	1.5417	-0.0733	-0.3418	0.0308	0.0612	0.0391	-0.0208	-0.0063	-0.0085	0.0341	0.0852	-0.0094	-0.0109	0.1232	0.0257	0.0799	-0.18	22.532	3.783
74	13.0972	2.5556	-6.8546	4.0799	-1.4376	10.0437	0.0229	-0.3923	-0.0463	0.2534	-0.0239	-0.174	0.1283	0.2857	0.001	0.1203	-0.0122	-0.0137	0.0881	0.0036	0.1075	-2.857	15.755	5.477
75	12.1171	-4.1373	-4.2168	14.8617	8.3761	5.1203	0.0109	-0.8736	-0.3625	0.8776	0.0427	-0.2183	0.5359	0.2159	-0.0535	0.1568	0.0209	-0.0165	0.1646	0.0266	0.0933	-8.554	10.348	4.857
76	1.405	0.3749	-0.1838	0.3628	-0.9777	3.3666	-0.0136	-0.1704	-0.2594	-0.0053	-0.0515	-0.0763	-0.0403	0.0973	0.0651	0.0866	-0.008	0.0082	0.0944	0.022	0.1321	-3.394	11.841	-6.553
77	6.2477	-1.3522	-0.4225	3.8655	-1.8375	1.7698	0.1781	0.1964	0.0084	-0.3851	0.0093	0.1877	0.0979	0.0463	-0.1874	0.1128	-0.0286	-0.0235	0.0966	0.0094	0.092	-7.832	17.302	-14.833
78	2.476	0.0966	0.0793	0.107	0.6837	4.5084	0.126	-0.0278	0.072	0.0233	-0.023	-0.0152	0.1267	-0.1082	-0.1029	0.1003	-0.0013	0.0053	0.0756	0.0304	0.1132	-6.472	17.942	-5.699
79	13.9041	5.5131	8.054	2.5705	1.2716	15.3308	0.0949	-0.0907	-0.3987	0.062	-0.0924	-0.2705	0.3749	0.5085	-0.0025	0.2549	0.074	-0.1085	0.1464	-0.0473	0.218	5.948	19.947	1.141
80	7.4667	2.0749	2.062	2.9827	0.5858	1.0678	0.0679	0.2564	-0.0945	0.0336	0.0652	-0.0105	0.0049	-0.0708	-0.1331	0.0925	0.0089	0.0116	0.103	0.0231	0.097	-5.571	13.981	-5.176
81	3.5057	-1.5365	-3.465	1.9924	2.3163	3.9107	0.4024	0.335	0.2541	0.0746	0.1083	-0.5439	-0.2308	-0.1938	-0.5107	0.1686	-0.0158	-0.0614	0.2492	-0.025	0.18	-13.694	2.635	21.006
82	1.5789	0.1622	0.8557	2.6126	-1.2237	1.1391	0.1069	-0.0301	-0.0087	0.1153	-0.2098	-0.2625	-0.0209	0.1022	0.1029	0.0997	-0.0444	0.0072	0.0914	0.0122	0.1082	-19.263	-5.445	8.561
83	2.3314	-0.0106	-0.8868	1.2646	-0.7595	1.5129	0.0577	0.1698	-0.0151	-0.0419	-0.0437	-0.0261	-0.0055	-0.0226	-0.014	0.0791	0.0026	0.006	0.0758	0.0006	0.0785	-20.254	5.075	-6.27
84	4.0096	3.0476	0.6222	2.8801	1.5799	2.7707	0.0983	0.1299	-0.0748	-0.0893	0.0436	-0.0938	0.0853	-0.2088	-0.1418	0.3867	-0.0216	-0.0566	0.1365	0.019	0.0719	-15.707	-4.89	-19.287
85	9.4338	-3.5336	7.9305	5.2668	-5.3441	8.0971	0.1578	-0.9678	-0.3549	-0.1576	0.2954	0.3787	0.1814	-0.7735	-0.4531	0.153	-0.0123	0.0101	0.2538	0.0388	0.0696	-24.038	-5.178	-15.862
86	2.1648	-1.7742	-1.9751	1.4768	1.5965	1.834	-0.0302	0.0033	0.0166	0.0218	0.0439	-0.0331	0.0683	-0.0409	-0.0137	0.1451	0.0293	-0.0377	0.1094	-0.026	0.1257	-13.56	-1.021	-5.244
87	1.252	0.5439	-0.7972	4.3787	0.1609	1.0671	0.023	-0.0399	0.0463	-0.0471	0.0218	-0.0086	0.0025	0.0402	-0.0448	0.0882	-0.0088	0.003	0.1043	0.0026	0.0703	-21.059	4.916	6.971
88	0.3372	-0.3031	-0.3394	0.8854	0.0992	0.4139	0.0669	-0.1454	0.1015	0.1845	0.0252	-0.1238	-0.1571	0.1817	-0.0921	0.1673	-0.1446	-0.0281	0.2647	0.0051	0.088	-17.531	-5.082	21.406

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	A	198 - 203
2	X-RAY DIFFRACTION	2	A	204 - 209
3	X-RAY DIFFRACTION	3	A	210 - 216
4	X-RAY DIFFRACTION	4	A	217 - 223
5	X-RAY DIFFRACTION	5	A	224 - 228
6	X-RAY DIFFRACTION	6	A	229 - 234
7	X-RAY DIFFRACTION	7	A	235 - 241
8	X-RAY DIFFRACTION	8	A	242 - 249
9	X-RAY DIFFRACTION	9	A	250 - 255
10	X-RAY DIFFRACTION	10	A	256 - 262
11	X-RAY DIFFRACTION	11	A	263 - 272
12	X-RAY DIFFRACTION	12	A	273 - 277
13	X-RAY DIFFRACTION	13	A	278 - 284
14	X-RAY DIFFRACTION	14	A	285 - 289
15	X-RAY DIFFRACTION	15	A	290 - 294
16	X-RAY DIFFRACTION	16	A	295 - 300
17	X-RAY DIFFRACTION	17	A	301 - 309
18	X-RAY DIFFRACTION	18	A	310 - 318
19	X-RAY DIFFRACTION	19	A	319 - 324
20	X-RAY DIFFRACTION	20	A	325 - 329
21	X-RAY DIFFRACTION	21	B	208 - 213
22	X-RAY DIFFRACTION	22	B	214 - 218
23	X-RAY DIFFRACTION	23	B	219 - 227
24	X-RAY DIFFRACTION	24	B	228 - 232
25	X-RAY DIFFRACTION	25	B	233 - 238
26	X-RAY DIFFRACTION	26	B	239 - 245
27	X-RAY DIFFRACTION	27	B	246 - 251
28	X-RAY DIFFRACTION	28	B	252 - 256
29	X-RAY DIFFRACTION	29	B	257 - 262
30	X-RAY DIFFRACTION	30	B	263 - 268
31	X-RAY DIFFRACTION	31	B	269 - 274
32	X-RAY DIFFRACTION	32	B	275 - 280
33	X-RAY DIFFRACTION	33	B	281 - 285
34	X-RAY DIFFRACTION	34	B	286 - 291
35	X-RAY DIFFRACTION	35	B	292 - 298
36	X-RAY DIFFRACTION	36	B	299 - 304
37	X-RAY DIFFRACTION	37	B	305 - 310
38	X-RAY DIFFRACTION	38	B	311 - 316
39	X-RAY DIFFRACTION	39	B	317 - 322
40	X-RAY DIFFRACTION	40	B	323 - 329
41	X-RAY DIFFRACTION	41	C	208 - 217
42	X-RAY DIFFRACTION	42	C	218 - 222
43	X-RAY DIFFRACTION	43	C	223 - 228
44	X-RAY DIFFRACTION	44	C	229 - 234
45	X-RAY DIFFRACTION	45	C	235 - 241
46	X-RAY DIFFRACTION	46	C	242 - 249
47	X-RAY DIFFRACTION	47	C	250 - 254
48	X-RAY DIFFRACTION	48	C	255 - 260
49	X-RAY DIFFRACTION	49	C	261 - 266
50	X-RAY DIFFRACTION	50	C	267 - 271
51	X-RAY DIFFRACTION	51	C	272 - 276
52	X-RAY DIFFRACTION	52	C	277 - 282
53	X-RAY DIFFRACTION	53	C	283 - 288
54	X-RAY DIFFRACTION	54	C	289 - 293
55	X-RAY DIFFRACTION	55	C	294 - 299
56	X-RAY DIFFRACTION	56	C	300 - 305
57	X-RAY DIFFRACTION	57	C	306 - 311
58	X-RAY DIFFRACTION	58	C	312 - 318
59	X-RAY DIFFRACTION	59	C	319 - 324
60	X-RAY DIFFRACTION	60	C	325 - 329
61	X-RAY DIFFRACTION	61	D	208 - 212
62	X-RAY DIFFRACTION	62	D	213 - 219
63	X-RAY DIFFRACTION	63	D	220 - 225
64	X-RAY DIFFRACTION	64	D	226 - 232
65	X-RAY DIFFRACTION	65	D	233 - 238
66	X-RAY DIFFRACTION	66	D	239 - 245
67	X-RAY DIFFRACTION	67	D	246 - 252
68	X-RAY DIFFRACTION	68	D	253 - 257
69	X-RAY DIFFRACTION	69	D	258 - 263
70	X-RAY DIFFRACTION	70	D	264 - 270
71	X-RAY DIFFRACTION	71	D	271 - 276
72	X-RAY DIFFRACTION	72	D	277 - 283
73	X-RAY DIFFRACTION	73	D	284 - 288
74	X-RAY DIFFRACTION	74	D	289 - 293
75	X-RAY DIFFRACTION	75	D	294 - 298
76	X-RAY DIFFRACTION	76	D	299 - 304
77	X-RAY DIFFRACTION	77	D	305 - 312
78	X-RAY DIFFRACTION	78	D	313 - 317
79	X-RAY DIFFRACTION	79	D	318 - 323
80	X-RAY DIFFRACTION	80	D	324 - 329
81	X-RAY DIFFRACTION	81	E	1 - 4
82	X-RAY DIFFRACTION	82	E	5 - 9
83	X-RAY DIFFRACTION	83	E	10 - 14
84	X-RAY DIFFRACTION	84	E	15 - 18
85	X-RAY DIFFRACTION	85	F	1 - 4
86	X-RAY DIFFRACTION	86	F	5 - 8
87	X-RAY DIFFRACTION	87	F	9 - 12
88	X-RAY DIFFRACTION	88	F	13 - 18

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