登録情報 | データベース: PDB / ID: 4e1n |
---|
タイトル | Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor |
---|
要素 | HIV-1 integrase |
---|
キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / HIV-1 / integrase / TRANSFERASE-TRANSFERASE INHIBITOR complex |
---|
機能・相同性 | 機能・相同性情報
HIV-1 retropepsin / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / viral genome integration into host DNA / RNA-directed DNA polymerase / establishment of integrated proviral latency / viral penetration into host nucleus ...HIV-1 retropepsin / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / viral genome integration into host DNA / RNA-directed DNA polymerase / establishment of integrated proviral latency / viral penetration into host nucleus / RNA stem-loop binding / RNA-directed DNA polymerase activity / host cell / RNA-DNA hybrid ribonuclease activity / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / symbiont-mediated suppression of host gene expression / viral nucleocapsid / DNA recombination / DNA-directed DNA polymerase / 加水分解酵素; エステル加水分解酵素 / aspartic-type endopeptidase activity / DNA-directed DNA polymerase activity / symbiont entry into host cell / lipid binding / host cell nucleus / host cell plasma membrane / structural molecule activity / virion membrane / proteolysis / DNA binding / zinc ion binding / membrane類似検索 - 分子機能 Ribonuclease H-like superfamily/Ribonuclease H / Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral ...Ribonuclease H-like superfamily/Ribonuclease H / Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain / Integrase, C-terminal, retroviral / Integrase DNA binding domain profile. / Immunodeficiency lentiviral matrix, N-terminal / gag gene protein p17 (matrix protein) / RNase H / Integrase core domain / Integrase, catalytic core / Integrase catalytic domain profile. / Retroviral nucleocapsid Gag protein p24, C-terminal domain / Gag protein p24 C-terminal domain / Retropepsin-like catalytic domain / Matrix protein, lentiviral and alpha-retroviral, N-terminal / Ribonuclease H domain / RNase H type-1 domain profile. / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Retrovirus capsid, C-terminal / Retroviral matrix protein / Retrovirus capsid, N-terminal / zinc finger / Zinc knuckle / Zinc finger, CCHC-type superfamily / Zinc finger, CCHC-type / Zinc finger CCHC-type profile. / Nucleotidyltransferase; domain 5 / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Ribonuclease H superfamily / Aspartic peptidase domain superfamily / Ribonuclease H-like superfamily / Reverse transcriptase/Diguanylate cyclase domain / DNA/RNA polymerase superfamily / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
---|
生物種 | ![](img/tx_virus.gif) Human immunodeficiency virus type 1 (ヒト免疫不全ウイルス) |
---|
手法 | X線回折 / 分子置換 / 解像度: 2 Å |
---|
データ登録者 | Lansdon, E.B. |
---|
引用 | ジャーナル: J.Biol.Chem. / 年: 2012 タイトル: New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action. 著者: Tsiang, M. / Jones, G.S. / Niedziela-Majka, A. / Kan, E. / Lansdon, E.B. / Huang, W. / Hung, M. / Samuel, D. / Novikov, N. / Xu, Y. / Mitchell, M. / Guo, H. / Babaoglu, K. / Liu, X. / ...著者: Tsiang, M. / Jones, G.S. / Niedziela-Majka, A. / Kan, E. / Lansdon, E.B. / Huang, W. / Hung, M. / Samuel, D. / Novikov, N. / Xu, Y. / Mitchell, M. / Guo, H. / Babaoglu, K. / Liu, X. / Geleziunas, R. / Sakowicz, R. |
---|
履歴 | 登録 | 2012年3月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2012年4月25日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2012年5月9日 | Group: Database references |
---|
改定 1.2 | 2012年7月25日 | Group: Database references |
---|
改定 1.3 | 2020年2月26日 | Group: Data collection / Database references / Derived calculations カテゴリ: reflns / reflns_shell ...reflns / reflns_shell / struct_conn / struct_ref_seq_dif Item: _reflns.pdbx_Rmerge_I_obs / _reflns_shell.Rmerge_I_obs ..._reflns.pdbx_Rmerge_I_obs / _reflns_shell.Rmerge_I_obs / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
---|
改定 1.4 | 2023年9月13日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|