登録情報 データベース : PDB / ID : 4dj9 構造の表示 ダウンロードとリンクタイトル Human vinculin head domain Vh1 (residues 1-258) in complex with the talin vinculin binding site 50 (VBS50, residues 2078-2099) 要素 詳細 キーワード CELL ADHESION / cytoskeleton / focal adhesion / protein-protein interaction / four-helix bundle / F-actin / cytosol機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of protein localization to adherens junction / podosome ring / outer dense plaque of desmosome / inner dense plaque of desmosome / terminal web / cell-substrate junction / epithelial cell-cell adhesion / zonula adherens / LIM domain binding / dystroglycan binding ... regulation of protein localization to adherens junction / podosome ring / outer dense plaque of desmosome / inner dense plaque of desmosome / terminal web / cell-substrate junction / epithelial cell-cell adhesion / zonula adherens / LIM domain binding / dystroglycan binding / alpha-catenin binding / vinculin binding / XBP1(S) activates chaperone genes / fascia adherens / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / cell-cell contact zone / integrin activation / apical junction assembly / adherens junction assembly / costamere / regulation of establishment of endothelial barrier / cell-substrate junction assembly / axon extension / protein localization to cell surface / cell-cell junction assembly / lamellipodium assembly / cortical actin cytoskeleton organization / regulation of focal adhesion assembly / maintenance of blood-brain barrier / p130Cas linkage to MAPK signaling for integrins / phosphatidylserine binding / brush border / GRB2:SOS provides linkage to MAPK signaling for Integrins / Smooth Muscle Contraction / ruffle / Integrin signaling / phosphatidylinositol binding / cell-matrix adhesion / negative regulation of cell migration / cell projection / integrin-mediated signaling pathway / morphogenesis of an epithelium / adherens junction / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / structural constituent of cytoskeleton / sarcolemma / platelet aggregation / cell-cell adhesion / ruffle membrane / beta-catenin binding / specific granule lumen / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / Signaling by BRAF and RAF1 fusions / actin filament binding / cell-cell junction / extracellular vesicle / Signaling by ALK fusions and activated point mutants / integrin binding / Platelet degranulation / actin binding / secretory granule lumen / ficolin-1-rich granule lumen / molecular adaptor activity / cytoskeleton / cell adhesion / cadherin binding / membrane raft / focal adhesion / ubiquitin protein ligase binding / Neutrophil degranulation / structural molecule activity / cell surface / protein-containing complex / extracellular exosome / extracellular region / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 Vinculin repeated domain signature. / : / Talin, R4 domain / Vinculin / Alpha-catenin/vinculin-like / Vinculin-binding site-containing domain / Talin, central / Talin, N-terminal F0 domain / Talin, central domain superfamily / Talin-1/2, rod-segment ... Vinculin repeated domain signature. / : / Talin, R4 domain / Vinculin / Alpha-catenin/vinculin-like / Vinculin-binding site-containing domain / Talin, central / Talin, N-terminal F0 domain / Talin, central domain superfamily / Talin-1/2, rod-segment / Vinculin Binding Site / Talin, middle domain / N-terminal or F0 domain of Talin-head FERM / I/LWEQ domain / I/LWEQ domain superfamily / I/LWEQ domain / I/LWEQ domain profile. / I/LWEQ domain / Vinculin, conserved site / Vinculin family talin-binding region signature. / Vinculin/alpha-catenin / Vinculin family / Phosphotyrosine-binding domain / Alpha-catenin/vinculin-like superfamily / FERM domain signature 1. / FERM conserved site / FERM domain signature 2. / FERM central domain / FERM/acyl-CoA-binding protein superfamily / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Four Helix Bundle (Hemerythrin (Met), subunit A) / PH-like domain superfamily / Ubiquitin-like domain superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.25 Å 詳細データ登録者 Yogesha, S.D. / Rangarajan, E.S. / Vonrhein, C. / Bricogne, G. / Izard, T. 引用ジャーナル : Protein Sci. / 年 : 2012タイトル : Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin.著者 : Yogesha, S.D. / Rangarajan, E.S. / Vonrhein, C. / Bricogne, G. / Izard, T. 履歴 登録 2012年2月1日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2012年2月29日 Provider : repository / タイプ : Initial release改定 1.1 2012年5月16日 Group : Database references改定 1.2 2024年2月28日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / software Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _software.name
すべて表示 表示を減らす