Entry Database : PDB / ID : 4aqj Structure visualization Downloads & linksTitle Structure of human S100A7 D24G bound to zinc and calcium ComponentsPROTEIN S100-A7 Details Keywords METAL BINDING PROTEIN / CANCER / INFLAMMATION / EF-HANDFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of granulocyte chemotaxis / zinc ion sequestering activity / Metal sequestration by antimicrobial proteins / positive regulation of T cell chemotaxis / RAGE receptor binding / positive regulation of monocyte chemotaxis / epidermis development / keratinocyte differentiation / response to reactive oxygen species / antimicrobial humoral immune response mediated by antimicrobial peptide ... positive regulation of granulocyte chemotaxis / zinc ion sequestering activity / Metal sequestration by antimicrobial proteins / positive regulation of T cell chemotaxis / RAGE receptor binding / positive regulation of monocyte chemotaxis / epidermis development / keratinocyte differentiation / response to reactive oxygen species / antimicrobial humoral immune response mediated by antimicrobial peptide / calcium-dependent protein binding / azurophil granule lumen / angiogenesis / collagen-containing extracellular matrix / response to lipopolysaccharide / positive regulation of ERK1 and ERK2 cascade / focal adhesion / calcium ion binding / Neutrophil degranulation / endoplasmic reticulum / extracellular space / zinc ion binding / extracellular region / nucleus / cytoplasm / cytosol Similarity search - Function S-100 / S-100/ICaBP type calcium binding protein signature. / S100/Calcium binding protein 7/8-like, conserved site / S100/CaBP-9k-type, calcium binding, subdomain / S-100/ICaBP type calcium binding domain / S-100/ICaBP type calcium binding domain / EF-hand / Recoverin; domain 1 / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. ... S-100 / S-100/ICaBP type calcium binding protein signature. / S100/Calcium binding protein 7/8-like, conserved site / S100/CaBP-9k-type, calcium binding, subdomain / S-100/ICaBP type calcium binding domain / S-100/ICaBP type calcium binding domain / EF-hand / Recoverin; domain 1 / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.6 Å DetailsAuthors Murray, J.I. / Tonkin, M.L. / Whiting, A.L. / Peng, F. / Farnell, B. / Hof, F. / Boulanger, M.J. CitationJournal : Bmc Struct.Biol. / Year : 2012Title : Structural Characterization of S100A15 Reveals a Novel Zinc Coordination Site Among S100 Proteins and Altered Surface Chemistry with Functional Implications for Receptor Binding.Authors : Murray, J.I. / Tonkin, M.L. / Whiting, A.L. / Peng, F. / Farnell, B. / Cullen, J.T. / Hof, F. / Boulanger, M.J. History Deposition Apr 17, 2012 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 17, 2012 Provider : repository / Type : Initial release