登録情報 データベース : PDB / ID : 3to6 構造の表示 ダウンロードとリンクタイトル Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor 要素Histone H4 Histone acetyltransferase ESA1 詳細キーワード TRANSFERASE/TRANSFERASE INHIBITOR / acetyltransferase / autoacetylation / TRANSFERASE-TRANSFERASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
DNA Damage/Telomere Stress Induced Senescence / Sensing of DNA Double Strand Breaks / piccolo histone acetyltransferase complex / HATs acetylate histones / peptide 2-hydroxyisobutyryltransferase activity / histone crotonyltransferase activity / RNA polymerase I upstream activating factor complex / positive regulation of triglyceride biosynthetic process / Condensation of Prophase Chromosomes / SIRT1 negatively regulates rRNA expression ... DNA Damage/Telomere Stress Induced Senescence / Sensing of DNA Double Strand Breaks / piccolo histone acetyltransferase complex / HATs acetylate histones / peptide 2-hydroxyisobutyryltransferase activity / histone crotonyltransferase activity / RNA polymerase I upstream activating factor complex / positive regulation of triglyceride biosynthetic process / Condensation of Prophase Chromosomes / SIRT1 negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / DNA-templated transcription elongation / Assembly of the ORC complex at the origin of replication / HDACs deacetylate histones / histone H4 acetyltransferase activity / rDNA heterochromatin formation / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / Oxidative Stress Induced Senescence / RMTs methylate histone arginines / SUMOylation of chromatin organization proteins / protein-lysine-acetyltransferase activity / NuA4 histone acetyltransferase complex / RNA Polymerase I Promoter Escape / positive regulation of transcription by RNA polymerase I / nucleolar large rRNA transcription by RNA polymerase I / histone acetyltransferase activity / Estrogen-dependent gene expression / positive regulation of macroautophagy / histone acetyltransferase / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / transcription coregulator activity / positive regulation of transcription elongation by RNA polymerase II / structural constituent of chromatin / nucleosome / nucleosome assembly / chromatin organization / regulation of cell cycle / protein heterodimerization activity / DNA repair / DNA-templated transcription / chromatin binding / regulation of transcription by RNA polymerase II / regulation of DNA-templated transcription / chromatin / DNA binding / identical protein binding / nucleus 類似検索 - 分子機能 N-acetyl transferase-like / : / MYST, zinc finger domain / MYST family zinc finger domain / Histone acetyltransferase domain, MYST-type / MOZ/SAS family / MYST-type histone acetyltransferase (HAT) domain profile. / RNA binding activity-knot of a chromodomain / RNA binding activity-knot of a chromodomain / Wheat Germ Agglutinin (Isolectin 2); domain 1 ... N-acetyl transferase-like / : / MYST, zinc finger domain / MYST family zinc finger domain / Histone acetyltransferase domain, MYST-type / MOZ/SAS family / MYST-type histone acetyltransferase (HAT) domain profile. / RNA binding activity-knot of a chromodomain / RNA binding activity-knot of a chromodomain / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Chromo/chromo shadow domain / Chromatin organization modifier domain / Chromo-like domain superfamily / Gcn5-related N-acetyltransferase (GNAT) / Acyl-CoA N-acyltransferase / Aminopeptidase / Histone H4, conserved site / Histone H4 signature. / Histone H4 / Histone H4 / CENP-T/Histone H4, histone fold / Centromere kinetochore component CENP-T histone fold / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Histone-fold / Arc Repressor Mutant, subunit A / Winged helix-like DNA-binding domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 CARBOXYMETHYL COENZYME *A / Histone H4 / Histone acetyltransferase ESA1 類似検索 - 構成要素生物種 Saccharomyces cerevisiae (パン酵母)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.1 Å 詳細データ登録者 Yuan, H. / Ding, E.C. / Marmorstein, R. 引用ジャーナル : Embo J. / 年 : 2011タイトル : MYST protein acetyltransferase activity requires active site lysine autoacetylation.著者: Yuan, H. / Rossetto, D. / Mellert, H. / Dang, W. / Srinivasan, M. / Johnson, J. / Hodawadekar, S. / Ding, E.C. / Speicher, K. / Abshiru, N. / Perry, R. / Wu, J. / Yang, C. / Zheng, Y.G. / ... 著者 : Yuan, H. / Rossetto, D. / Mellert, H. / Dang, W. / Srinivasan, M. / Johnson, J. / Hodawadekar, S. / Ding, E.C. / Speicher, K. / Abshiru, N. / Perry, R. / Wu, J. / Yang, C. / Zheng, Y.G. / Speicher, D.W. / Thibault, P. / Verreault, A. / Johnson, F.B. / Berger, S.L. / Sternglanz, R. / McMahon, S.B. / Cote, J. / Marmorstein, R. 履歴 登録 2011年9月4日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2011年11月9日 Provider : repository / タイプ : Initial release改定 1.1 2012年1月18日 Group : Database references改定 1.2 2023年9月13日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.3 2023年12月6日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2改定 1.4 2024年10月16日 Group : Structure summaryカテゴリ : pdbx_entry_details / pdbx_modification_feature
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