Entry | Database: PDB / ID: 3qbv |
---|
Title | Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin |
---|
Components | - Cell division control protein 42 homolog
- Intersectin-1
|
---|
Keywords | PROTEIN BINDING/SIGNALING PROTEIN / Computationally designed / orthogonal interaction / GTPase / nucleotide exchange / cell membrane / GTP-binding / lipoprotein / membrane / methylation / nucleotide-binding / prenylation / cell junction / cell projection / endocytosis / phosphoprotein / SH3 domain / synapse / synaptosome / protein binding-signaling protein complex |
---|
Function / homology | Function and homology information
clathrin-dependent synaptic vesicle endocytosis / GBD domain binding / submandibular salivary gland formation / actin filament branching / Golgi transport complex / positive regulation of pinocytosis / modification of synaptic structure / endothelin receptor signaling pathway involved in heart process / Cdc42 protein signal transduction / cardiac neural crest cell migration involved in outflow tract morphogenesis ...clathrin-dependent synaptic vesicle endocytosis / GBD domain binding / submandibular salivary gland formation / actin filament branching / Golgi transport complex / positive regulation of pinocytosis / modification of synaptic structure / endothelin receptor signaling pathway involved in heart process / Cdc42 protein signal transduction / cardiac neural crest cell migration involved in outflow tract morphogenesis / positive regulation of synapse structural plasticity / dendritic cell migration / storage vacuole / positive regulation of epithelial cell proliferation involved in lung morphogenesis / apolipoprotein A-I receptor binding / neuron fate determination / modulation by host of viral process / GTP-dependent protein binding / organelle transport along microtubule / regulation of attachment of spindle microtubules to kinetochore / positive regulation of pseudopodium assembly / cardiac conduction system development / Inactivation of CDC42 and RAC1 / establishment of Golgi localization / leading edge membrane / regulation of filopodium assembly / neuropilin signaling pathway / positive regulation of intracellular protein transport / cell junction assembly / filopodium assembly / establishment of epithelial cell apical/basal polarity / mitogen-activated protein kinase kinase kinase binding / regulation of modification of postsynaptic structure / dendritic spine morphogenesis / embryonic heart tube development / thioesterase binding / regulation of stress fiber assembly / RHO GTPases activate KTN1 / proline-rich region binding / nuclear migration / regulation of lamellipodium assembly / adherens junction organization / sprouting angiogenesis / DCC mediated attractive signaling / regulation of small GTPase mediated signal transduction / Wnt signaling pathway, planar cell polarity pathway / CD28 dependent Vav1 pathway / positive regulation of filopodium assembly / regulation of postsynapse organization / endosomal transport / regulation of mitotic nuclear division / RHOV GTPase cycle / establishment or maintenance of cell polarity / intracellular vesicle / phagocytosis, engulfment / heart contraction / NRAGE signals death through JNK / Myogenesis / RHOJ GTPase cycle / Golgi organization / exocytosis / RHOQ GTPase cycle / positive regulation of cytokinesis / RHO GTPases activate PAKs / CDC42 GTPase cycle / RHOU GTPase cycle / macrophage differentiation / RHOG GTPase cycle / RAC2 GTPase cycle / RHO GTPases Activate WASPs and WAVEs / RAC3 GTPase cycle / RHO GTPases activate IQGAPs / spindle midzone / negative regulation of protein-containing complex assembly / positive regulation of lamellipodium assembly / positive regulation of substrate adhesion-dependent cell spreading / clathrin-coated pit / phagocytic vesicle / positive regulation of stress fiber assembly / GPVI-mediated activation cascade / EPHB-mediated forward signaling / RAC1 GTPase cycle / substantia nigra development / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / small monomeric GTPase / G protein activity / guanyl-nucleotide exchange factor activity / positive regulation of DNA replication / secretory granule / filopodium / actin filament organization / integrin-mediated signaling pathway / RHO GTPases Activate Formins / regulation of actin cytoskeleton organization / positive regulation of JNK cascade / FCGR3A-mediated phagocytosis / EGFR downregulation / MAPK6/MAPK4 signaling / Schaffer collateral - CA1 synapse / recycling endosomeSimilarity search - Function Intersectin-1, AP2 binding region / Intersectin and clathrin adaptor AP2 binding region / : / Pleckstrin homology domain / Cdc42 / Cytoskeletal-regulatory complex EF hand / EH domain profile. / Eps15 homology domain / EH domain / Dbl Homology Domain; Chain A ...Intersectin-1, AP2 binding region / Intersectin and clathrin adaptor AP2 binding region / : / Pleckstrin homology domain / Cdc42 / Cytoskeletal-regulatory complex EF hand / EH domain profile. / Eps15 homology domain / EH domain / Dbl Homology Domain; Chain A / Dbl homology (DH) domain / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / Variant SH3 domain / Variant SH3 domain / Small GTPase Rho / small GTPase Rho family profile. / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / SH3 domain / Small GTPase / Ras family / Rab subfamily of small GTPases / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / Src homology 3 domains / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / EF-hand domain / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand domain pair / Small GTP-binding protein domain / PH-like domain superfamily / P-loop containing nucleotide triphosphate hydrolases / Roll / Up-down Bundle / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Mainly Beta / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
---|
Biological species | Homo sapiens (human) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.65 Å |
---|
Authors | Kapp, G.T. / Remenyi, A. / Lim, W.A. / Kortemme, T. |
---|
Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2012 Title: Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Authors: Kapp, G.T. / Liu, S. / Stein, A. / Wong, D.T. / Remenyi, A. / Yeh, B.J. / Fraser, J.S. / Taunton, J. / Lim, W.A. / Kortemme, T. |
---|
History | Deposition | Jan 14, 2011 | Deposition site: RCSB / Processing site: RCSB |
---|
Revision 1.0 | Feb 8, 2012 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Mar 21, 2012 | Group: Database references |
---|
Revision 1.2 | Apr 18, 2012 | Group: Database references |
---|
Revision 1.3 | Apr 25, 2012 | Group: Database references |
---|
Revision 1.4 | Sep 13, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|