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Structure paper

TitleControl of protein signaling using a computationally designed GTPase/GEF orthogonal pair.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 5277-5282, Year 2012
Publish dateJan 14, 2011 (structure data deposition date)
AuthorsKapp, G.T. / Liu, S. / Stein, A. / Wong, D.T. / Remenyi, A. / Yeh, B.J. / Fraser, J.S. / Taunton, J. / Lim, W.A. / Kortemme, T.
External linksProc. Natl. Acad. Sci. USA / PubMed:22403064
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-3qbv:
Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING/SIGNALING PROTEIN / Computationally designed / orthogonal interaction / GTPase / nucleotide exchange / cell membrane / GTP-binding / lipoprotein / membrane / methylation / nucleotide-binding / prenylation / cell junction / cell projection / endocytosis / phosphoprotein / SH3 domain / synapse / synaptosome / protein binding-signaling protein complex

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