登録情報 データベース : PDB / ID : 3n56 構造の表示 ダウンロードとリンクタイトル Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP) 要素Insulin-degrading enzyme Natriuretic peptides B 詳細キーワード HYDROLASE/HORMONE / INSULYSIN / INSULINASE / A-BETA DEGRADING ENZYME / CRYPTIDASE / HYDROLASE / HORMONE / DISEASE MUTATION / DIABETES MELLITUS / INSULIN / CARDIAC / SECRETED / PROTEASE / DISULFIDE BOND / METALLOPROTEASE / HUMAN INSULIN-DEGRADNG ENZYME / METAL-BINDING / NATRIURETIC PEPTIDE / NATRIURETIC FACTOR / CARDIOVASCULAR REGULATION / HYDROLASE-HORMONE complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
diuretic hormone activity / body fluid secretion / receptor guanylyl cyclase signaling pathway / positive regulation of renal sodium excretion / cGMP biosynthetic process / insulysin / ubiquitin recycling / insulin catabolic process / insulin metabolic process / regulation of vascular permeability ... diuretic hormone activity / body fluid secretion / receptor guanylyl cyclase signaling pathway / positive regulation of renal sodium excretion / cGMP biosynthetic process / insulysin / ubiquitin recycling / insulin catabolic process / insulin metabolic process / regulation of vascular permeability / cardiac conduction system development / amyloid-beta clearance by cellular catabolic process / positive regulation of urine volume / hormone catabolic process / bradykinin catabolic process / negative regulation of systemic arterial blood pressure / hormone receptor binding / ubiquitin-modified protein reader activity / insulin binding / regulation of aerobic respiration / peptide catabolic process / cGMP-mediated signaling / amyloid-beta clearance / peroxisomal matrix / neuropeptide signaling pathway / amyloid-beta metabolic process / Insulin receptor recycling / blood vessel diameter maintenance / negative regulation of angiogenesis / proteolysis involved in protein catabolic process / Peroxisomal protein import / peptide binding / protein catabolic process / hormone activity / negative regulation of cell growth / antigen processing and presentation of endogenous peptide antigen via MHC class I / metalloendopeptidase activity / regulation of blood pressure / positive regulation of protein catabolic process / vasodilation / peroxisome / protein folding / positive regulation of protein binding / insulin receptor signaling pathway / virus receptor activity / basolateral plasma membrane / endopeptidase activity / cell surface receptor signaling pathway / Ub-specific processing proteases / external side of plasma membrane / signaling receptor binding / cell surface / protein homodimerization activity / protein-containing complex / mitochondrion / proteolysis / extracellular space / zinc ion binding / extracellular exosome / extracellular region / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Natriuretic peptide, brain type / Natriuretic peptide, conserved site / Atrial natriuretic peptide / Natriuretic peptides signature. / Natriuretic peptide / Natriuretic peptide / Peptidase M16, middle/third domain / Middle or third domain of peptidase_M16 / Cytochrome Bc1 Complex; Chain A, domain 1 / Metalloenzyme, LuxS/M16 peptidase-like ... Natriuretic peptide, brain type / Natriuretic peptide, conserved site / Atrial natriuretic peptide / Natriuretic peptides signature. / Natriuretic peptide / Natriuretic peptide / Peptidase M16, middle/third domain / Middle or third domain of peptidase_M16 / Cytochrome Bc1 Complex; Chain A, domain 1 / Metalloenzyme, LuxS/M16 peptidase-like / Peptidase M16, zinc-binding site / Insulinase family, zinc-binding region signature. / Peptidase M16, C-terminal / Peptidase M16 inactive domain / Peptidase M16, N-terminal / Insulinase (Peptidase family M16) / Metalloenzyme, LuxS/M16 peptidase-like / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 1,4-DIETHYLENE DIOXIDE / Insulin-degrading enzyme / Natriuretic peptides B 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.102 Å 詳細データ登録者 Funke, T. / Guo, Q. / Tang, W.-J. 引用ジャーナル : To be Published タイトル : Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)著者 : Ralat, L.A. / Funke, T. / Ren, M. / Guo, Q. / Dickey, D.M. / Potter, L.R. / Tang, W.-J. 履歴 登録 2010年5月24日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2010年11月17日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2017年11月8日 Group : Refinement description / カテゴリ : software改定 1.3 2023年9月6日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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