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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 3hhr | |||||||||
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タイトル | HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX | |||||||||
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![]() | HORMONE/RECEPTOR / HORMONE-RECEPTOR complex | |||||||||
機能・相同性 | ![]() growth hormone receptor activity / regulation of response to nutrient levels / growth hormone activity / growth hormone receptor complex / bone maturation / prolactin receptor binding / positive regulation of growth / taurine metabolic process / animal organ development / positive regulation of activation of Janus kinase activity ...growth hormone receptor activity / regulation of response to nutrient levels / growth hormone activity / growth hormone receptor complex / bone maturation / prolactin receptor binding / positive regulation of growth / taurine metabolic process / animal organ development / positive regulation of activation of Janus kinase activity / response to gravity / cartilage development involved in endochondral bone morphogenesis / positive regulation of multicellular organism growth / hormone metabolic process / positive regulation of glucose transmembrane transport / proline-rich region binding / positive regulation of insulin-like growth factor receptor signaling pathway / growth hormone receptor binding / response to food / growth hormone receptor signaling pathway / response to cycloheximide / cytokine binding / Prolactin receptor signaling / growth factor binding / cell surface receptor signaling pathway via JAK-STAT / peptide hormone binding / regulation of multicellular organism growth / Synthesis, secretion, and deacylation of Ghrelin / Growth hormone receptor signaling / response to glucocorticoid / positive regulation of tyrosine phosphorylation of STAT protein / cellular response to hormone stimulus / hormone-mediated signaling pathway / response to interleukin-1 / SH2 domain binding / response to nutrient levels / insulin-like growth factor receptor signaling pathway / cytokine activity / endosome lumen / positive regulation of cell differentiation / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / positive regulation of MAP kinase activity / hormone activity / receptor internalization / cytokine-mediated signaling pathway / cytoplasmic ribonucleoprotein granule / endocytosis / cellular response to insulin stimulus / positive regulation of peptidyl-tyrosine phosphorylation / response to estradiol / protein phosphatase binding / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor complex / external side of plasma membrane / neuronal cell body / lipid binding / protein kinase binding / cell surface / protein homodimerization activity / extracellular space / extracellular region / identical protein binding / membrane / metal ion binding / plasma membrane / cytosol 類似検索 - 分子機能 | |||||||||
生物種 | ![]() | |||||||||
手法 | ![]() | |||||||||
![]() | De Vos, A.M. / Ultsch, M. / Kossiakoff, A.A. | |||||||||
![]() | ![]() タイトル: Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. 著者: de Vos, A.M. / Ultsch, M. / Kossiakoff, A.A. #1: ![]() タイトル: Crystals of the Complex between Human Growth Hormone and the Extracellular Domain of its Receptor 著者: Ultsch, M. / De Vos, A.M. / Kossiakoff, A.A. #2: ![]() タイトル: Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule 著者: Cunningham, B.C. / Ultsch, M. / De Vos, A.M. / Mulkerrin, M.G. / Clauser, K.R. / Wells, J.A. | |||||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 123.6 KB | 表示 | ![]() |
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PDB形式 | ![]() | 96.5 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 383.9 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 405.5 KB | 表示 | |
XML形式データ | ![]() | 14.4 KB | 表示 | |
CIF形式データ | ![]() | 21.4 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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単位格子 |
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Atom site foot note | 1: ASP B 52 - GLU B 53 OMEGA =220.92 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 2: GLU B 53 - VAL B 54 OMEGA =214.97 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 3: LEU B 233 - PRO B 234 OMEGA = 31.98 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION 4: GLY C 62 - PRO C 63 OMEGA =149.08 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION |
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要素
#1: タンパク質 | 分子量: 22004.818 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() |
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#2: タンパク質 | 分子量: 24004.004 Da / 分子数: 2 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() |
-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 2.71 Å3/Da / 溶媒含有率: 54.66 % | |||||||||||||||||||||||||||||||||||
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結晶化 | *PLUS pH: 7.5 / 手法: 蒸気拡散法, ハンギングドロップ法 / 詳細: referred to J.Mol.Biol. 222.865-868 | |||||||||||||||||||||||||||||||||||
溶液の組成 | *PLUS
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-データ収集
反射 | *PLUS 最高解像度: 2.8 Å / 最低解像度: 15 Å / Rmerge(I) obs: 0.204 |
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解析
ソフトウェア |
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精密化 | Rfactor Rwork: 0.221 / Rfactor obs: 0.221 / 最高解像度: 2.8 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化ステップ | サイクル: LAST / 最高解像度: 2.8 Å
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拘束条件 |
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ソフトウェア | *PLUS 名称: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化 | *PLUS Rfactor obs: 0.221 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
溶媒の処理 | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
原子変位パラメータ | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
拘束条件 | *PLUS タイプ: x_angle_d / Dev ideal: 3.2 |