- PDB-3h3g: Crystal structure of the extracellular domain of the human parath... -
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Basic information
Entry
Database: PDB / ID: 3h3g
Title
Crystal structure of the extracellular domain of the human parathyroid hormone receptor (PTH1R) in complex with parathyroid hormone-related protein (PTHrP)
Components
Fusion protein of Maltose-binding periplasmic domain and human parathyroid hormone receptor extracellular domain
Parathyroid hormone-related protein
Keywords
MEMBRANE PROTEIN / GPCR / extracellular domain / PTHrP / PTH / PTHR1 / Sugar transport / Transport / Hormone
Function / homology
Function and homology information
negative regulation of chondrocyte development / regulation of chondrocyte differentiation / parathyroid hormone receptor activity / cAMP metabolic process / G protein-coupled peptide receptor activity / negative regulation of chondrocyte differentiation / Class B/2 (Secretin family receptors) / osteoblast development / positive regulation of inositol phosphate biosynthetic process / peptide hormone receptor binding ...negative regulation of chondrocyte development / regulation of chondrocyte differentiation / parathyroid hormone receptor activity / cAMP metabolic process / G protein-coupled peptide receptor activity / negative regulation of chondrocyte differentiation / Class B/2 (Secretin family receptors) / osteoblast development / positive regulation of inositol phosphate biosynthetic process / peptide hormone receptor binding / detection of maltose stimulus / maltose transport complex / bone mineralization / maltose binding / maltose transport / maltodextrin transmembrane transport / peptide hormone binding / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / carbohydrate transport / carbohydrate transmembrane transporter activity / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / epidermis development / chondrocyte differentiation / cell maturation / bone resorption / ATP-binding cassette (ABC) transporter complex / cell chemotaxis / skeletal system development / female pregnancy / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / intracellular calcium ion homeostasis / : / cell-cell signaling / phospholipase C-activating G protein-coupled receptor signaling pathway / outer membrane-bounded periplasmic space / G alpha (s) signalling events / regulation of gene expression / basolateral plasma membrane / in utero embryonic development / cell population proliferation / periplasmic space / cell surface receptor signaling pathway / receptor complex / apical plasma membrane / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / DNA damage response / positive regulation of cell population proliferation / Golgi apparatus / protein homodimerization activity / extracellular space / extracellular region / nucleoplasm / membrane / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function
Parathyroid hormone-related protein / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / Parathyroid hormone/parathyroid hormone-related protein / Parathyroid hormone family / Parathyroid hormone family signature. / Parathyroid hormone / GPCR, family 2, parathyroid hormone receptor / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain ...Parathyroid hormone-related protein / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / Parathyroid hormone/parathyroid hormone-related protein / Parathyroid hormone family / Parathyroid hormone family signature. / Parathyroid hormone / GPCR, family 2, parathyroid hormone receptor / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein / Periplasmic binding protein-like II / D-Maltodextrin-Binding Protein; domain 2 / Few Secondary Structures / Irregular / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homology
alpha-maltose / Maltose/maltodextrin-binding periplasmic protein / Parathyroid hormone-related protein / Parathyroid hormone/parathyroid hormone-related peptide receptor Similarity search - Component
A: Fusion protein of Maltose-binding periplasmic domain and human parathyroid hormone receptor extracellular domain B: Parathyroid hormone-related protein hetero molecules
FusionproteinofMaltose-bindingperiplasmicdomainandhumanparathyroidhormonereceptorextracellulardomain / / Maltodextrin-binding protein / MMBP / PTH/PTHr receptor / PTH/PTHrP type I receptor
Mass: 60297.941 Da / Num. of mol.: 1 / Fragment: extracellular domain Source method: isolated from a genetically manipulated source Source: (gene. exp.) Escherichia coli (E. coli), (gene. exp.) Homo sapiens (human) Gene: b4034, JW3994, malE, PTHR1 / Production host: Escherichia coli (E. coli) / References: UniProt: P0AEX9, UniProt: Q03431
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