- PDB-3fbk: Crystal structure of the C2 domain of the human regulator of G-pr... -
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ID or keywords:
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Basic information
Entry
Database: PDB / ID: 3fbk
Title
Crystal structure of the C2 domain of the human regulator of G-protein signaling 3 isoform 6 (RGP3), Northeast Structural Genomics Consortium Target HR5550A
Components
Regulator of G-protein signaling 3
Keywords
SIGNALING PROTEIN / all beta-sheet fold / Structural Genomics / PSI-2 / Protein Structure Initiative / Northeast Structural Genomics Consortium / NESG / Alternative splicing / Cell membrane / Cytoplasm / Membrane / Nucleus / Phosphoprotein / Signal transduction inhibitor
Function / homology
Function and homology information
regulation of G protein-coupled receptor signaling pathway / negative regulation of signal transduction / GTPase activator activity / G alpha (i) signalling events / G alpha (q) signalling events / G protein-coupled receptor signaling pathway / GTPase activity / nucleus / plasma membrane / cytosol Similarity search - Function
Regulator of G-protein signalling 3, RGS domain / RGS, subdomain 1/3 / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / C2 domain / C2 domain ...Regulator of G-protein signalling 3, RGS domain / RGS, subdomain 1/3 / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / C2 domain / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / C2 domain superfamily / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / PH-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homology
Mass: 18.015 Da / Num. of mol.: 170 / Source method: isolated from a natural source / Formula: H2O
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 1.97 Å3/Da / Density % sol: 37.54 %
Crystal grow
Temperature: 291 K / Method: microbatch under oil / pH: 7 Details: Protein solution: 10 mM Tris (pH 7.5), 100 mM sodium chloride, and 5 mM DTT. Reservoir solution: 100 mM Bis-Tris Propane (pH 7), 40% PEG 1000, and 100 mM (NH4)2 SO4. , microbatch under oil, temperature 291K
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