+Open data
-Basic information
Entry | Database: PDB / ID: 3ei4 | ||||||
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Title | Structure of the hsDDB1-hsDDB2 complex | ||||||
Components |
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Keywords | DNA BINDING PROTEIN / UV-damage / DDB / nucleotide excision repair / xeroderma pigmentosum / Disease mutation / DNA damage / DNA repair / DNA-binding / Nucleus / Phosphoprotein / WD repeat | ||||||
Function / homology | Function and homology information positive regulation by virus of viral protein levels in host cell / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / biological process involved in interaction with symbiont / regulation of mitotic cell cycle phase transition / Cul4A-RING E3 ubiquitin ligase complex / WD40-repeat domain binding / ubiquitin ligase complex scaffold activity ...positive regulation by virus of viral protein levels in host cell / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / biological process involved in interaction with symbiont / regulation of mitotic cell cycle phase transition / Cul4A-RING E3 ubiquitin ligase complex / WD40-repeat domain binding / ubiquitin ligase complex scaffold activity / Cul4B-RING E3 ubiquitin ligase complex / negative regulation of reproductive process / negative regulation of developmental process / site of DNA damage / cullin family protein binding / viral release from host cell / pyrimidine dimer repair / ectopic germ cell programmed cell death / proteasomal protein catabolic process / protein autoubiquitination / positive regulation of viral genome replication / response to UV / positive regulation of gluconeogenesis / regulation of circadian rhythm / nucleotide-excision repair / TP53 Regulates Transcription of DNA Repair Genes / Recognition of DNA damage by PCNA-containing replication complex / DNA Damage Recognition in GG-NER / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / Formation of TC-NER Pre-Incision Complex / Dual Incision in GG-NER / Wnt signaling pathway / Formation of Incision Complex in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / protein polyubiquitination / positive regulation of protein catabolic process / rhythmic process / cell junction / cellular response to UV / Neddylation / protein-macromolecule adaptor activity / site of double-strand break / chromosome, telomeric region / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / damaged DNA binding / Ub-specific processing proteases / protein ubiquitination / DNA repair / DNA damage response / chromatin / negative regulation of apoptotic process / protein-containing complex binding / nucleolus / apoptotic process / protein-containing complex / DNA binding / extracellular space / extracellular exosome / nucleoplasm / nucleus / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 3.3 Å | ||||||
Authors | Scrima, A. / Pavletich, N.P. / Thoma, N.H. | ||||||
Citation | Journal: Cell(Cambridge,Mass.) / Year: 2008 Title: Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Authors: Scrima, A. / Konickova, R. / Czyzewski, B.K. / Kawasaki, Y. / Jeffrey, P.D. / Groisman, R. / Nakatani, Y. / Iwai, S. / Pavletich, N.P. / Thoma, N.H. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3ei4.cif.gz | 879 KB | Display | PDBx/mmCIF format |
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PDB format | pdb3ei4.ent.gz | 702.7 KB | Display | PDB format |
PDBx/mmJSON format | 3ei4.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 3ei4_validation.pdf.gz | 530.9 KB | Display | wwPDB validaton report |
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Full document | 3ei4_full_validation.pdf.gz | 738 KB | Display | |
Data in XML | 3ei4_validation.xml.gz | 169.2 KB | Display | |
Data in CIF | 3ei4_validation.cif.gz | 224.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ei/3ei4 ftp://data.pdbj.org/pub/pdb/validation_reports/ei/3ei4 | HTTPS FTP |
-Related structure data
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Refine code: 1
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