- PDB-3eh2: Crystal structure of the human COPII-coat protein Sec24c -
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Basic information
Entry
Database: PDB / ID: 3eh2
Title
Crystal structure of the human COPII-coat protein Sec24c
Components
Protein transport protein Sec24CProtein targeting
Keywords
PROTEIN TRANSPORT / COPII-coat protein / vesicle transport / Cytoplasm / Endoplasmic reticulum / ER-Golgi transport / Golgi apparatus / Membrane / Phosphoprotein / Transport
Function / homology
Function and homology information
COPII-coated vesicle cargo loading / COPII vesicle coat / Regulation of cholesterol biosynthesis by SREBP (SREBF) / Cargo concentration in the ER / COPII-mediated vesicle transport / endoplasmic reticulum to Golgi vesicle-mediated transport / endoplasmic reticulum exit site / MHC class II antigen presentation / SNARE binding / Antigen Presentation: Folding, assembly and peptide loading of class I MHC ...COPII-coated vesicle cargo loading / COPII vesicle coat / Regulation of cholesterol biosynthesis by SREBP (SREBF) / Cargo concentration in the ER / COPII-mediated vesicle transport / endoplasmic reticulum to Golgi vesicle-mediated transport / endoplasmic reticulum exit site / MHC class II antigen presentation / SNARE binding / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / intracellular protein transport / ER to Golgi transport vesicle membrane / in utero embryonic development / endoplasmic reticulum membrane / SARS-CoV-2 activates/modulates innate and adaptive immune responses / zinc ion binding / cytosol Similarity search - Function
Mass: 18.015 Da / Num. of mol.: 240 / Source method: isolated from a natural source / Formula: H2O
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.5 Å3/Da / Density % sol: 50.89 %
Crystal grow
Temperature: 300 K / Method: vapor diffusion, hanging drop / pH: 7.5 Details: CRYSTALS WERE GROWN VIA THE HANGING-DROP METHOD, BY ADDING 1UL PROTEIN SOLUTION TO 1UL OF WELL SOLUTION COMPRISING 6% (W/V) PEG 4000 AND 0.1 M MES., pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 300K
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