- PDB-3eh1: Crystal structure of the human COPII-coat protein Sec24b -
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ID or keywords:
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Basic information
Entry
Database: PDB / ID: 3eh1
Title
Crystal structure of the human COPII-coat protein Sec24b
Components
Protein transport protein Sec24B
Keywords
PROTEIN TRANSPORT / COPII coat protein / vesicle transport / transport signal sequence / Cytoplasm / Endoplasmic reticulum / ER-Golgi transport / Golgi apparatus / Membrane / Phosphoprotein / Transport
Function / homology
Function and homology information
regulation of establishment of planar polarity involved in neural tube closure / regulation of cargo loading into COPII-coated vesicle / pulmonary artery morphogenesis / aorta morphogenesis / cochlear nucleus development / COPII-coated vesicle cargo loading / lung lobe morphogenesis / COPII vesicle coat / COPII vesicle coating / coronary artery morphogenesis ...regulation of establishment of planar polarity involved in neural tube closure / regulation of cargo loading into COPII-coated vesicle / pulmonary artery morphogenesis / aorta morphogenesis / cochlear nucleus development / COPII-coated vesicle cargo loading / lung lobe morphogenesis / COPII vesicle coat / COPII vesicle coating / coronary artery morphogenesis / Regulation of cholesterol biosynthesis by SREBP (SREBF) / Cargo concentration in the ER / antigen processing and presentation of peptide antigen via MHC class I / auditory receptor cell stereocilium organization / COPII-mediated vesicle transport / outflow tract morphogenesis / endoplasmic reticulum to Golgi vesicle-mediated transport / MHC class II antigen presentation / neural tube closure / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / intracellular protein transport / ER to Golgi transport vesicle membrane / antigen processing and presentation of exogenous peptide antigen via MHC class II / Golgi membrane / endoplasmic reticulum membrane / zinc ion binding / cytosol Similarity search - Function
Mass: 18.015 Da / Num. of mol.: 691 / Source method: isolated from a natural source / Formula: H2O
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.3 Å3/Da / Density % sol: 46.46 %
Crystal grow
Temperature: 300 K / Method: vapor diffusion, hanging drop / pH: 7.5 Details: Protein was concentrated to 40 mg/ml in 150 mM NaCl, 20 mM Tris pH 7.5, 4 mM DTT. Crystals were grown via the hanging-drop method, by adding 1ul protein solution to 1ul of well solution ...Details: Protein was concentrated to 40 mg/ml in 150 mM NaCl, 20 mM Tris pH 7.5, 4 mM DTT. Crystals were grown via the hanging-drop method, by adding 1ul protein solution to 1ul of well solution comprising 42% ethylene glycol, VAPOR DIFFUSION, HANGING DROP, temperature 300K
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