- PDB-3d2u: Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a ... -
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Basic information
Entry
Database: PDB / ID: 3d2u
Title
Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a Host Inhibitory Receptor
Components
Actin
Beta-2-microglobulinBeta-2 microglobulin
Leukocyte immunoglobulin-like receptor subfamily B member 1
UL18 protein
Keywords
IMMUNE SYSTEM / MHC class I homolog / Disease mutation / Glycation / Glycoprotein / Immune response / Immunoglobulin domain / MHC I / Pyrrolidone carboxylic acid / Secreted / Membrane / Phosphoprotein / Receptor / Transmembrane
Function / homology
Function and homology information
evasion by virus of host natural killer cell activity / HLA-A specific inhibitory MHC class I receptor activity / positive regulation of gamma-delta T cell activation involved in immune response / MHC class Ib protein complex binding / HLA-B specific inhibitory MHC class I receptor activity / inhibitory MHC class I receptor activity / negative regulation of dendritic cell differentiation / immune response-inhibiting cell surface receptor signaling pathway / MHC class Ib protein binding / Fc receptor mediated inhibitory signaling pathway ...evasion by virus of host natural killer cell activity / HLA-A specific inhibitory MHC class I receptor activity / positive regulation of gamma-delta T cell activation involved in immune response / MHC class Ib protein complex binding / HLA-B specific inhibitory MHC class I receptor activity / inhibitory MHC class I receptor activity / negative regulation of dendritic cell differentiation / immune response-inhibiting cell surface receptor signaling pathway / MHC class Ib protein binding / Fc receptor mediated inhibitory signaling pathway / MHC class Ib receptor activity / positive regulation of norepinephrine uptake / negative regulation of T cell mediated cytotoxicity / MHC class I receptor activity / negative regulation of CD8-positive, alpha-beta T cell activation / cellular response to cytochalasin B / negative regulation of transforming growth factor beta production / negative regulation of alpha-beta T cell activation / bBAF complex / npBAF complex / negative regulation of cytokine production involved in immune response / postsynaptic actin cytoskeleton organization / negative regulation of serotonin secretion / regulation of transepithelial transport / brahma complex / nBAF complex / dendritic cell differentiation / structural constituent of postsynaptic actin cytoskeleton / morphogenesis of a polarized epithelium / GBAF complex / negative regulation of mononuclear cell proliferation / negative regulation of natural killer cell mediated cytotoxicity / postsynaptic actin cytoskeleton / negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / protein localization to adherens junction / protein phosphatase 1 binding / regulation of G0 to G1 transition / Formation of annular gap junctions / dense body / Tat protein binding / Gap junction degradation / negative regulation of osteoclast development / Cell-extracellular matrix interactions / Folding of actin by CCT/TriC / regulation of double-strand break repair / negative regulation of interleukin-12 production / regulation of nucleotide-excision repair / negative regulation of endocytosis / negative regulation of interferon-beta production / apical protein localization / negative regulation of dendritic cell apoptotic process / Prefoldin mediated transfer of substrate to CCT/TriC / adherens junction assembly / antigen processing and presentation of peptide antigen via MHC class I / RHOF GTPase cycle / RSC-type complex / Adherens junctions interactions / tight junction / Sensory processing of sound by outer hair cells of the cochlea / Interaction between L1 and Ankyrins / Sensory processing of sound by inner hair cells of the cochlea / regulation of mitotic metaphase/anaphase transition / SWI/SNF complex / positive regulation of macrophage cytokine production / regulation of norepinephrine uptake / positive regulation of double-strand break repair / positive regulation of T cell differentiation / regulation of synaptic vesicle endocytosis / NuA4 histone acetyltransferase complex / apical junction complex / establishment or maintenance of cell polarity / maintenance of blood-brain barrier / negative regulation of interleukin-10 production / positive regulation of stem cell population maintenance / cortical cytoskeleton / T cell proliferation involved in immune response / nitric-oxide synthase binding / regulation of cyclin-dependent protein serine/threonine kinase activity / Recycling pathway of L1 / regulation of G1/S transition of mitotic cell cycle / MHC class I protein binding / kinesin binding / negative regulation of cell differentiation / calyx of Held / brush border / negative regulation of calcium ion transport / negative regulation of type II interferon production / negative regulation of tumor necrosis factor production / negative regulation of cell cycle / positive regulation of double-strand break repair via homologous recombination / EPH-ephrin mediated repulsion of cells / host cell membrane / RHO GTPases Activate WASPs and WAVEs / RHO GTPases activate IQGAPs / positive regulation of myoblast differentiation / regulation of protein localization to plasma membrane / negative regulation of T cell proliferation / positive regulation of defense response to virus by host / EPHB-mediated forward signaling / substantia nigra development Similarity search - Function
Immunoglobulin domain / Immunoglobulin / Immunoglobulin domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Actin / Actin family ...Immunoglobulin domain / Immunoglobulin / Immunoglobulin domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Actin / Actin family / Actin / MHC class I-like antigen recognition-like / Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 / Class I Histocompatibility antigen, domains alpha 1 and 2 / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Beta-2-Microglobulin / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / ATPase, nucleotide binding domain / MHC classes I/II-like antigen recognition protein / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homology
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