登録情報 | データベース: PDB / ID: 3cx8 |
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タイトル | Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GTP-gamma-S |
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要素 | - Guanine nucleotide-binding protein alpha-13 subunit
- Rho guanine nucleotide exchange factor 11
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キーワード | SIGNALING PROTEIN / SIGNAL TRANSDUCTION / PROTEIN COMPLEX / GTP-binding / Lipoprotein / Membrane / Nucleotide-binding / Palmitate / Phosphoprotein / Transducer / Coiled coil / Cytoplasm / GTPase activation / Guanine-nucleotide releasing factor |
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機能・相同性 | 機能・相同性情報
Sema4D induced cell migration and growth-cone collapse / D5 dopamine receptor binding / RHOB GTPase cycle / CDC42 GTPase cycle / NRAGE signals death through JNK / G alpha (12/13) signalling events / RAC1 GTPase cycle / CDC42 GTPase cycle / regulation of fibroblast migration / Thromboxane signalling through TP receptor ...Sema4D induced cell migration and growth-cone collapse / D5 dopamine receptor binding / RHOB GTPase cycle / CDC42 GTPase cycle / NRAGE signals death through JNK / G alpha (12/13) signalling events / RAC1 GTPase cycle / CDC42 GTPase cycle / regulation of fibroblast migration / Thromboxane signalling through TP receptor / NRAGE signals death through JNK / RHOA GTPase cycle / positive regulation of L-glutamate import across plasma membrane / Thrombin signalling through proteinase activated receptors (PARs) / RAC1 GTPase cycle / G alpha (12/13) signalling events / negative regulation of vascular associated smooth muscle cell migration / branching involved in blood vessel morphogenesis / negative regulation of vascular associated smooth muscle cell proliferation / Rho protein signal transduction / GTPase activator activity / guanyl-nucleotide exchange factor activity / G protein-coupled receptor binding / brush border membrane / G-protein beta/gamma-subunit complex binding / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / platelet activation / regulation of blood pressure / heterotrimeric G-protein complex / melanosome / regulation of cell shape / positive regulation of cytosolic calcium ion concentration / angiogenesis / in utero embryonic development / cell differentiation / intracellular signal transduction / G protein-coupled receptor signaling pathway / GTPase activity / GTP binding / positive regulation of DNA-templated transcription / membrane / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 G-protein alpha subunit, group 12/13 / Rho guanine nucleotide exchange factor 11, PH domain / Rho guanine nucleotide exchange factor 11, RGS domain / Regulator of G protein signalling-like domain / Regulator of G protein signalling-like domain / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / ARHGEF1-like, PH domain / PH domain / GI Alpha 1, domain 2-like ...G-protein alpha subunit, group 12/13 / Rho guanine nucleotide exchange factor 11, PH domain / Rho guanine nucleotide exchange factor 11, RGS domain / Regulator of G protein signalling-like domain / Regulator of G protein signalling-like domain / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / ARHGEF1-like, PH domain / PH domain / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / RGS, subdomain 2 / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / PH domain profile. / PDZ domain / Pleckstrin homology domain. / Pleckstrin homology domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / PDZ domain / PDZ superfamily / PH-like domain superfamily / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE / Guanine nucleotide-binding protein subunit alpha-13 / Rho guanine nucleotide exchange factor 11類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ)
![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 解像度: 2 Å |
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データ登録者 | Sprang, S.R. / Chen, Z. |
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引用 | ジャーナル: Structure / 年: 2008 タイトル: Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF. 著者: Chen, Z. / Singer, W.D. / Danesh, S.M. / Sternweis, P.C. / Sprang, S.R. |
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履歴 | 登録 | 2008年4月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2008年10月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software Item: _software.classification / _software.contact_author ..._software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version |
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改定 1.3 | 2023年8月30日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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