Entry Database : PDB / ID : 3biw Structure visualization Downloads & linksTitle Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex ComponentsNeurexin-1-beta Neuroligin-1 DetailsKeywords Cell adhesion/Cell adhesion / protein-protein complex / esterase domain / LNS domain / alpha-beta hydrolase / Cell adhesion / Cell junction / Glycoprotein / Membrane / Postsynaptic cell membrane / Synapse / Transmembrane / Alternative promoter usage / Cell adhesion-Cell adhesion COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
trans-synaptic signaling by endocannabinoid / neurexin clustering involved in presynaptic membrane assembly / regulation of presynapse organization / protein-containing complex assembly involved in synapse maturation / : / regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission / positive regulation of presynaptic active zone assembly / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness ... trans-synaptic signaling by endocannabinoid / neurexin clustering involved in presynaptic membrane assembly / regulation of presynapse organization / protein-containing complex assembly involved in synapse maturation / : / regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission / positive regulation of presynaptic active zone assembly / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness / retrograde trans-synaptic signaling by trans-synaptic protein complex / regulation of postsynaptic specialization assembly / protein complex involved in cell-cell adhesion / gephyrin clustering involved in postsynaptic density assembly / type 1 fibroblast growth factor receptor binding / positive regulation of neuromuscular synaptic transmission / guanylate kinase-associated protein clustering / terminal button organization / neuron to neuron synapse / positive regulation of synaptic vesicle exocytosis / : / neuroligin clustering involved in postsynaptic membrane assembly / excitatory synapse assembly / postsynaptic density protein 95 clustering / cerebellar granule cell differentiation / postsynaptic specialization assembly / negative regulation of dendritic spine morphogenesis / postsynaptic membrane assembly / gamma-aminobutyric acid receptor clustering / neuronal ion channel clustering / positive regulation of synaptic vesicle clustering / presynaptic membrane assembly / synapse maturation / Neurexins and neuroligins / negative regulation of filopodium assembly / maintenance of synapse structure / vocal learning / neuroligin family protein binding / positive regulation of fibroblast growth factor receptor signaling pathway / positive regulation of synapse maturation / regulation of postsynaptic density assembly / inhibitory synapse / synaptic vesicle clustering / synaptic vesicle targeting / neuron cell-cell adhesion / synaptic membrane adhesion / regulation of respiratory gaseous exchange by nervous system process / neurexin family protein binding / regulation of grooming behavior / presynapse assembly / filopodium tip / receptor localization to synapse / protein localization to synapse / NMDA glutamate receptor clustering / vocalization behavior / regulation of synaptic vesicle cycle / neuron projection arborization / positive regulation of synaptic vesicle endocytosis / regulation of insulin secretion involved in cellular response to glucose stimulus / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / neurotransmitter secretion / AMPA glutamate receptor clustering / regulation of AMPA receptor activity / filopodium assembly / neuron maturation / vesicle docking involved in exocytosis / acetylcholine receptor binding / positive regulation of synapse assembly / positive regulation of ruffle assembly / regulation of NMDA receptor activity / positive regulation of protein kinase C activity / postsynaptic specialization membrane / positive regulation of intracellular signal transduction / positive regulation of filopodium assembly / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / regulation of neuron differentiation / positive regulation of protein localization to synapse / synaptic vesicle transport / adult behavior / positive regulation of dendritic spine development / positive regulation of protein kinase A signaling / positive regulation of excitatory postsynaptic potential / social behavior / neuromuscular process controlling balance / synaptic vesicle endocytosis / regulation of presynapse assembly / endocytic vesicle / excitatory synapse / calcium channel regulator activity / GABA-ergic synapse / protein targeting / prepulse inhibition / axonal growth cone / synaptic cleft / presynaptic active zone membrane / cell adhesion molecule binding / synapse assembly / cellular response to calcium ion / positive regulation of synaptic transmission, glutamatergic / neuron projection morphogenesis Similarity search - Function Neuroligin / : / Syndecan/Neurexin domain / Syndecan domain / : / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif / Laminin G domain / Laminin G domain profile. / Laminin G domain ... Neuroligin / : / Syndecan/Neurexin domain / Syndecan domain / : / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif / Laminin G domain / Laminin G domain profile. / Laminin G domain / Laminin G domain / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase, type B / Carboxylesterase family / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / Aspartic acid and asparagine hydroxylation site. / Epidermal growth factor-like domain. / Jelly Rolls - #200 / EGF-like domain profile. / EGF-like domain / Alpha/Beta hydrolase fold, catalytic domain / Concanavalin A-like lectin/glucanase domain superfamily / Alpha/Beta hydrolase fold / Jelly Rolls / Sandwich / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 3.5 Å DetailsAuthors Arac, D. / Boucard, A.A. / Ozkan, E. / Strop, P. / Newell, E. / Sudhof, T.C. / Brunger, A.T. CitationJournal : Neuron / Year : 2007Title : Structures of Neuroligin-1 and the Neuroligin-1/Neurexin-1beta Complex Reveal Specific Protein-Protein and Protein-Ca(2+) Interactions.Authors : Arac, D. / Boucard, A.A. / Ozkan, E. / Strop, P. / Newell, E. / Sudhof, T.C. / Brunger, A.T. History Deposition Dec 1, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 18, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Non-polymer description / Version format complianceRevision 1.2 Aug 23, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.3 Oct 25, 2017 Group : Refinement description / Category : softwareRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / struct_asym / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : Remediation
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