Entry Database : PDB / ID : 3b3q Structure visualization Downloads & linksTitle Crystal structure of a synaptic adhesion complex ComponentsNRXN1 protein Nlgn1 protein DetailsKeywords CELL ADHESION / synaptic formation / adhesion / heterophilic / protein-protein complex / calcium binding / Membrane / TransmembraneFunction / homology Function and homology informationFunction Domain/homology Component
neurexin clustering involved in presynaptic membrane assembly / regulation of presynapse organization / protein-containing complex assembly involved in synapse maturation / : / positive regulation of presynaptic active zone assembly / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness / retrograde trans-synaptic signaling by trans-synaptic protein complex / protein complex involved in cell-cell adhesion ... neurexin clustering involved in presynaptic membrane assembly / regulation of presynapse organization / protein-containing complex assembly involved in synapse maturation / : / positive regulation of presynaptic active zone assembly / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness / retrograde trans-synaptic signaling by trans-synaptic protein complex / protein complex involved in cell-cell adhesion / gephyrin clustering involved in postsynaptic density assembly / Neurexins and neuroligins / type 1 fibroblast growth factor receptor binding / positive regulation of neuromuscular synaptic transmission / guanylate kinase-associated protein clustering / terminal button organization / neuron to neuron synapse / positive regulation of synaptic vesicle exocytosis / neuronal signal transduction / neuroligin clustering involved in postsynaptic membrane assembly / excitatory synapse assembly / postsynaptic density protein 95 clustering / cerebellar granule cell differentiation / negative regulation of dendritic spine morphogenesis / postsynaptic membrane assembly / positive regulation of synaptic vesicle clustering / synapse maturation / presynaptic membrane assembly / gamma-aminobutyric acid receptor clustering / negative regulation of filopodium assembly / maintenance of synapse structure / neuroligin family protein binding / synaptic vesicle targeting / positive regulation of fibroblast growth factor receptor signaling pathway / inhibitory synapse / synaptic vesicle clustering / synaptic membrane adhesion / regulation of respiratory gaseous exchange by nervous system process / neuron cell-cell adhesion / neurexin family protein binding / filopodium tip / receptor localization to synapse / protein localization to synapse / NMDA glutamate receptor clustering / vocalization behavior / neuron projection arborization / positive regulation of synaptic vesicle endocytosis / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / regulation of AMPA receptor activity / AMPA glutamate receptor clustering / Neurexins and neuroligins / positive regulation of synapse assembly / positive regulation of ruffle assembly / NMDA selective glutamate receptor complex / regulation of NMDA receptor activity / positive regulation of protein kinase C activity / positive regulation of intracellular signal transduction / positive regulation of filopodium assembly / positive regulation of protein localization to synapse / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / regulation of neuron differentiation / synaptic vesicle transport / adult behavior / positive regulation of dendritic spine development / positive regulation of protein kinase A signaling / plasma membrane => GO:0005886 / positive regulation of excitatory postsynaptic potential / social behavior / excitatory synapse / synaptic vesicle endocytosis / endocytic vesicle / GABA-ergic synapse / protein targeting / axonal growth cone / synaptic cleft / cell adhesion molecule binding / synapse assembly / cellular response to calcium ion / positive regulation of synaptic transmission, glutamatergic / neuron projection morphogenesis / dendritic shaft / learning / PDZ domain binding / positive regulation of synaptic transmission, GABAergic / long-term synaptic potentiation / positive regulation of protein localization to plasma membrane / synapse organization / modulation of chemical synaptic transmission / establishment of protein localization / neuromuscular junction / positive regulation of neuron projection development / transmembrane signaling receptor activity / calcium-dependent protein binding / neuron projection development / rhythmic process / presynapse / positive regulation of peptidyl-serine phosphorylation / presynaptic membrane / nervous system development / signaling receptor activity Similarity search - Function Neuroligin-1 / Neuroligin / Syndecan/Neurexin domain / Syndecan domain / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif / Laminin G domain / Laminin G domain profile. / Laminin G domain / Laminin G domain ... Neuroligin-1 / Neuroligin / Syndecan/Neurexin domain / Syndecan domain / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif / Laminin G domain / Laminin G domain profile. / Laminin G domain / Laminin G domain / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase, type B / Carboxylesterase family / Jelly Rolls - #200 / Alpha/Beta hydrolase fold, catalytic domain / Concanavalin A-like lectin/glucanase domain superfamily / Alpha/Beta hydrolase fold / Jelly Rolls / Sandwich / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.4 Å DetailsAuthors Chen, X. / Liu, H. / Shim, A. / Focia, P. / He, X. CitationJournal : Nat.Struct.Mol.Biol. / Year : 2008Title : Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions.Authors : Chen, X. / Liu, H. / Shim, A.H. / Focia, P.J. / He, X. History Deposition Oct 22, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 15, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Non-polymer description / Version format complianceRevision 1.2 May 15, 2013 Group : Structure summaryRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / pdbx_unobs_or_zero_occ_atoms / struct_asym / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Aug 30, 2023 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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