Entry | Database: PDB / ID: 2xb6 |
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Title | Revisited crystal structure of Neurexin1beta-Neuroligin4 complex |
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Components | - NEUREXIN-1-BETA
- NEUROLIGIN-4, X-LINKED
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Keywords | CELL ADHESION / ALPHA-BETA-HYDROLASE FOLD / AUTISM / CONFORMATIONAL REARRANGEMENT |
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Function / homology | Function and homology information
asymmetric, glutamatergic, excitatory synapse / protein-containing complex assembly involved in synapse maturation / symmetric, GABA-ergic, inhibitory synapse / regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission / positive regulation of presynaptic active zone assembly / cell-cell adhesion involved in synapse maturation / regulation of postsynaptic specialization assembly / protein complex involved in cell-cell adhesion / gephyrin clustering involved in postsynaptic density assembly / type 1 fibroblast growth factor receptor binding ...asymmetric, glutamatergic, excitatory synapse / protein-containing complex assembly involved in synapse maturation / symmetric, GABA-ergic, inhibitory synapse / regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission / positive regulation of presynaptic active zone assembly / cell-cell adhesion involved in synapse maturation / regulation of postsynaptic specialization assembly / protein complex involved in cell-cell adhesion / gephyrin clustering involved in postsynaptic density assembly / type 1 fibroblast growth factor receptor binding / positive regulation of neuromuscular synaptic transmission / guanylate kinase-associated protein clustering / neuron to neuron synapse / neuroligin clustering involved in postsynaptic membrane assembly / postsynaptic density protein 95 clustering / cerebellar granule cell differentiation / postsynaptic membrane assembly / synapse maturation / presynaptic membrane assembly / gamma-aminobutyric acid receptor clustering / negative regulation of filopodium assembly / maintenance of synapse structure / vocal learning / neuroligin family protein binding / positive regulation of synapse maturation / positive regulation of fibroblast growth factor receptor signaling pathway / regulation of postsynaptic density assembly / inhibitory synapse / synaptic vesicle clustering / synaptic membrane adhesion / brainstem development / regulation of grooming behavior / neuron cell-cell adhesion / presynapse assembly / neurexin family protein binding / negative regulation of excitatory postsynaptic potential / receptor localization to synapse / regulation of synaptic vesicle cycle / protein localization to synapse / NMDA glutamate receptor clustering / vocalization behavior / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / regulation of AMPA receptor activity / neurotransmitter secretion / cell-cell junction organization / filopodium assembly / neuron maturation / acetylcholine receptor binding / Neurexins and neuroligins / positive regulation of synapse assembly / regulation of NMDA receptor activity / chloride ion binding / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / organ growth / adult behavior / positive regulation of protein kinase A signaling / positive regulation of excitatory postsynaptic potential / social behavior / neuromuscular process controlling balance / regulation of presynapse assembly / excitatory synapse / synaptic vesicle endocytosis / calcium channel regulator activity / endocytic vesicle / GABA-ergic synapse / prepulse inhibition / axonal growth cone / presynaptic active zone membrane / cell adhesion molecule binding / synapse assembly / cellular response to calcium ion / positive regulation of synaptic transmission, glutamatergic / cerebellum development / neuron projection morphogenesis / learning / positive regulation of synaptic transmission, GABAergic / positive regulation of protein localization to plasma membrane / postsynaptic density membrane / synapse organization / Schaffer collateral - CA1 synapse / modulation of chemical synaptic transmission / establishment of protein localization / neuromuscular junction / neuron differentiation / positive regulation of neuron projection development / circadian rhythm / transmembrane signaling receptor activity / calcium-dependent protein binding / neuron projection development / presynapse / positive regulation of peptidyl-serine phosphorylation / presynaptic membrane / signaling receptor activity / scaffold protein binding / chemical synaptic transmission / nuclear membrane / angiogenesis / vesicle / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascadeSimilarity search - Function Neuroligin / Syndecan/Neurexin domain / Syndecan domain / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif / Laminin G domain / Laminin G domain profile. / Laminin G domain / Laminin G domain / Carboxylesterase type B, conserved site ...Neuroligin / Syndecan/Neurexin domain / Syndecan domain / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif / Laminin G domain / Laminin G domain profile. / Laminin G domain / Laminin G domain / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase, type B / Carboxylesterase family / Jelly Rolls - #200 / Alpha/Beta hydrolase fold, catalytic domain / Concanavalin A-like lectin/glucanase domain superfamily / Alpha/Beta hydrolase fold / Jelly Rolls / Sandwich / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human)
![](img/tx_mammal.gif) RATTUS NORVEGICUS (Norway rat) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.6 Å |
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Authors | Leone, P. / Comoletti, D. / Ferracci, G. / Conrod, S. / Garcia, S.U. / Taylor, P. / Bourne, Y. / Marchot, P. |
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Citation | Journal: Embo J. / Year: 2010 Title: Structural Insights Into the Exquisite Selectivity of Neurexin-Neuroligin Synaptic Interactions Authors: Leone, P. / Comoletti, D. / Ferracci, G. / Conrod, S. / Garcia, S.U. / Taylor, P. / Bourne, Y. / Marchot, P. |
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History | Deposition | Apr 7, 2010 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jun 23, 2010 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Refinement description / Version format compliance |
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Revision 1.2 | Apr 3, 2019 | Group: Data collection / Derived calculations ...Data collection / Derived calculations / Other / Source and taxonomy Category: entity_src_gen / pdbx_database_proc ...entity_src_gen / pdbx_database_proc / pdbx_database_status / struct_biol / struct_conn Item: _entity_src_gen.pdbx_host_org_cell_line / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id ..._entity_src_gen.pdbx_host_org_cell_line / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_variant / _pdbx_database_status.recvd_author_approval / _struct_conn.pdbx_leaving_atom_flag |
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Revision 1.3 | Jul 29, 2020 | Group: Data collection / Derived calculations ...Data collection / Derived calculations / Other / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_database_status / pdbx_entity_nonpoly / pdbx_struct_conn_angle / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_database_status.status_code_sf / _pdbx_entity_nonpoly.name / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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Revision 1.4 | Dec 20, 2023 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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