Entry Database : PDB / ID : 3bix Structure visualization Downloads & linksTitle Crystal structure of the extracellular esterase domain of Neuroligin-1 ComponentsNeuroligin-1 Details Keywords CELL ADHESION / esterase domain / alpha-beta hydrolase / Cell junction / Glycoprotein / Membrane / Postsynaptic cell membrane / Synapse / TransmembraneFunction / homology Function and homology informationFunction Domain/homology Component
neurexin clustering involved in presynaptic membrane assembly / regulation of presynapse organization / positive regulation of presynaptic active zone assembly / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness / retrograde trans-synaptic signaling by trans-synaptic protein complex / protein complex involved in cell-cell adhesion / positive regulation of neuromuscular synaptic transmission / terminal button organization ... neurexin clustering involved in presynaptic membrane assembly / regulation of presynapse organization / positive regulation of presynaptic active zone assembly / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness / retrograde trans-synaptic signaling by trans-synaptic protein complex / protein complex involved in cell-cell adhesion / positive regulation of neuromuscular synaptic transmission / terminal button organization / neuron to neuron synapse / positive regulation of synaptic vesicle exocytosis / excitatory synapse assembly / postsynaptic density protein 95 clustering / postsynaptic specialization assembly / negative regulation of dendritic spine morphogenesis / postsynaptic membrane assembly / neuronal ion channel clustering / positive regulation of synaptic vesicle clustering / presynaptic membrane assembly / synapse maturation / Neurexins and neuroligins / maintenance of synapse structure / inhibitory synapse / synaptic vesicle clustering / synaptic vesicle targeting / neuron cell-cell adhesion / synaptic membrane adhesion / regulation of respiratory gaseous exchange by nervous system process / neurexin family protein binding / filopodium tip / receptor localization to synapse / protein localization to synapse / NMDA glutamate receptor clustering / neuron projection arborization / positive regulation of synaptic vesicle endocytosis / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / AMPA glutamate receptor clustering / regulation of AMPA receptor activity / positive regulation of synapse assembly / positive regulation of ruffle assembly / regulation of NMDA receptor activity / postsynaptic specialization membrane / positive regulation of intracellular signal transduction / positive regulation of filopodium assembly / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / regulation of neuron differentiation / positive regulation of protein localization to synapse / synaptic vesicle transport / positive regulation of dendritic spine development / positive regulation of excitatory postsynaptic potential / synaptic vesicle endocytosis / excitatory synapse / GABA-ergic synapse / protein targeting / synaptic cleft / cell adhesion molecule binding / synapse assembly / cellular response to calcium ion / positive regulation of synaptic transmission, glutamatergic / neuron projection morphogenesis / dendritic shaft / positive regulation of synaptic transmission, GABAergic / PDZ domain binding / long-term synaptic potentiation / synapse organization / modulation of chemical synaptic transmission / establishment of protein localization / neuromuscular junction / positive regulation of neuron projection development / neuron projection development / rhythmic process / presynapse / signaling receptor activity / nervous system development / scaffold protein binding / chemical synaptic transmission / dendritic spine / postsynaptic density / receptor complex / external side of plasma membrane / glutamatergic synapse / synapse / dendrite / protein-containing complex binding / Golgi apparatus / cell surface / identical protein binding / plasma membrane Similarity search - Function Neuroligin / : / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase, type B / Carboxylesterase family / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.8 Å DetailsAuthors Arac, D. / Boucard, A.A. / Ozkan, E. / Strop, P. / Newell, E. / Sudhof, T.C. / Brunger, A.T. CitationJournal : Neuron / Year : 2007Title : Structures of Neuroligin-1 and the Neuroligin-1/Neurexin-1beta Complex Reveal Specific Protein-Protein and Protein-Ca(2+) Interactions.Authors : Arac, D. / Boucard, A.A. / Ozkan, E. / Strop, P. / Newell, E. / Sudhof, T.C. / Brunger, A.T. History Deposition Dec 1, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 18, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Non-polymer description / Version format complianceRevision 1.2 Aug 23, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.3 Oct 25, 2017 Group : Refinement description / Category : softwareRevision 1.4 Jul 29, 2020 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary Category : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : Remediation
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