Entry Database : PDB / ID : 3b71 Structure visualization Downloads & linksTitle CD4 endocytosis motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase ComponentsFocal adhesion kinase 1 T-cell surface glycoprotein CD4 DetailsKeywords PROTEIN BINDING / Four-helix bundle / protein-protein complex / ATP-binding / Cell junction / Kinase / Nucleotide-binding / Phosphorylation / Transferase / Tyrosine-protein kinase / Glycoprotein / Host-virus interaction / Immune response / Immunoglobulin domain / Lipoprotein / Membrane / Palmitate / TransmembraneFunction / homology Function and homology informationFunction Domain/homology Component
netrin-activated signaling pathway / regulation of substrate adhesion-dependent cell spreading / regulation of endothelial cell migration / helper T cell enhancement of adaptive immune response / interleukin-16 binding / interleukin-16 receptor activity / regulation of epithelial cell migration / maintenance of protein location in cell / T cell selection / detection of muscle stretch ... netrin-activated signaling pathway / regulation of substrate adhesion-dependent cell spreading / regulation of endothelial cell migration / helper T cell enhancement of adaptive immune response / interleukin-16 binding / interleukin-16 receptor activity / regulation of epithelial cell migration / maintenance of protein location in cell / T cell selection / detection of muscle stretch / MHC class II protein binding / positive regulation of ubiquitin-dependent protein catabolic process / JUN kinase binding / cellular response to granulocyte macrophage colony-stimulating factor stimulus / interleukin-15-mediated signaling pathway / positive regulation of monocyte differentiation / Nef Mediated CD4 Down-regulation / signal complex assembly / Alpha-defensins / positive regulation of kinase activity / positive regulation of macrophage proliferation / positive regulation of fibroblast migration / DCC mediated attractive signaling / regulation of T cell activation / Signal regulatory protein family interactions / growth hormone receptor signaling pathway / regulation of osteoblast differentiation / T cell receptor complex / MET activates PTK2 signaling / regulation of focal adhesion assembly / extracellular matrix structural constituent / Other interleukin signaling / establishment of cell polarity / positive regulation of wound healing / regulation of GTPase activity / negative regulation of cell-cell adhesion / positive regulation of macrophage chemotaxis / enzyme-linked receptor protein signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / p130Cas linkage to MAPK signaling for integrins / positive regulation of epithelial cell migration / regulation of cytoskeleton organization / Translocation of ZAP-70 to Immunological synapse / Apoptotic cleavage of cellular proteins / Phosphorylation of CD3 and TCR zeta chains / regulation of cell adhesion mediated by integrin / regulation of calcium ion transport / GRB2:SOS provides linkage to MAPK signaling for Integrins / macrophage differentiation / Generation of second messenger molecules / negative regulation of anoikis / T cell differentiation / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / PD-1 signaling / RHO GTPases Activate WASPs and WAVEs / ephrin receptor signaling pathway / positive regulation of protein kinase activity / Binding and entry of HIV virion / regulation of cell adhesion / coreceptor activity / vascular endothelial growth factor receptor signaling pathway / positive regulation of calcium-mediated signaling / positive regulation of epithelial to mesenchymal transition / heart morphogenesis / stress fiber / cell surface receptor protein tyrosine kinase signaling pathway / EPHB-mediated forward signaling / positive regulation of interleukin-2 production / T cell activation / NCAM signaling for neurite out-growth / SH2 domain binding / Integrin signaling / transforming growth factor beta receptor signaling pathway / protein tyrosine kinase binding / ciliary basal body / protein tyrosine phosphatase activity / molecular function activator activity / Vpu mediated degradation of CD4 / integrin-mediated signaling pathway / cell motility / calcium-mediated signaling / FCGR3A-mediated phagocytosis / axon guidance / non-specific protein-tyrosine kinase / regulation of protein phosphorylation / clathrin-coated endocytic vesicle membrane / non-membrane spanning protein tyrosine kinase activity / placenta development / epidermal growth factor receptor signaling pathway / Regulation of actin dynamics for phagocytic cup formation / VEGFA-VEGFR2 Pathway / peptidyl-tyrosine phosphorylation / transmembrane signaling receptor activity / positive regulation of peptidyl-tyrosine phosphorylation / cell migration / integrin binding / Cargo recognition for clathrin-mediated endocytosis / Downstream TCR signaling / positive regulation of T cell activation / MHC class II protein complex binding Similarity search - Function Single helix bin / Nucleotidyltransferases domain 2 / Focal adhesion kinase, targeting (FAT) domain / Focal adhesion kinase, targeting (FAT) domain superfamily / Focal adhesion kinase, N-terminal / FAK1/PYK2, FERM domain C-lobe / Focal adhesion targeting region / FERM N-terminal domain / CD4, extracellular / T cell CD4 receptor C-terminal region ... Single helix bin / Nucleotidyltransferases domain 2 / Focal adhesion kinase, targeting (FAT) domain / Focal adhesion kinase, targeting (FAT) domain superfamily / Focal adhesion kinase, N-terminal / FAK1/PYK2, FERM domain C-lobe / Focal adhesion targeting region / FERM N-terminal domain / CD4, extracellular / T cell CD4 receptor C-terminal region / CD4, extracellular / T cell CD4 receptor C terminal region / T-cell surface antigen CD4 / : / FAK1/PYK2, FERM domain C-lobe / Immunoglobulin C2-set / Immunoglobulin C2-set domain / FERM domain signature 2. / FERM central domain / FERM/acyl-CoA-binding protein superfamily / FERM central domain / Immunoglobulin / Immunoglobulin domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Four Helix Bundle (Hemerythrin (Met), subunit A) / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Immunoglobulin V-set domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ubiquitin-like domain superfamily / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.82 Å DetailsAuthors Garron, M.-L. / Arold, S.T. CitationJournal : J.Mol.Biol. / Year : 2008Title : Structural basis for the interaction between focal adhesion kinase and CD4.Authors : Garron, M.L. / Arthos, J. / Guichou, J.F. / McNally, J. / Cicala, C. / Arold, S.T. History Deposition Oct 30, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 1, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.2 Aug 30, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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