- PDB-3aa1: Crystal structure of Actin capping protein in complex with the Cp... -
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基本情報
登録情報
データベース: PDB / ID: 3aa1
タイトル
Crystal structure of Actin capping protein in complex with the Cp-binding motif derived from CKIP-1
要素
23mer peptide from Pleckstrin homology domain-containing family O member 1
F-actin-capping protein subunit alpha-1
F-actin-capping protein subunit beta isoforms 1 and 2
キーワード
PROTEIN BINDING / ACTIN CAPPING PROTEIN / BARBED END REGULATION / CARMIL FAMILY PROTEIN / CONFORMATIONAL CHANGE / CELL MOTILITY / Actin capping / Actin-binding / Cytoskeleton / Cell membrane / Tumor suppressor
機能・相同性
機能・相同性情報
muscle cell projection membrane / Advanced glycosylation endproduct receptor signaling / RHOD GTPase cycle / RHOF GTPase cycle / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / COPI-independent Golgi-to-ER retrograde traffic / lamellipodium morphogenesis / COPI-mediated anterograde transport / Factors involved in megakaryocyte development and platelet production / WASH complex ...muscle cell projection membrane / Advanced glycosylation endproduct receptor signaling / RHOD GTPase cycle / RHOF GTPase cycle / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / COPI-independent Golgi-to-ER retrograde traffic / lamellipodium morphogenesis / COPI-mediated anterograde transport / Factors involved in megakaryocyte development and platelet production / WASH complex / : / F-actin capping protein complex / myoblast migration / negative regulation of filopodium assembly / cell junction assembly / myoblast fusion / barbed-end actin filament capping / actin polymerization or depolymerization / regulation of cell morphogenesis / regulation of lamellipodium assembly / lamellipodium assembly / cortical cytoskeleton / brush border / cytoskeleton organization / hippocampal mossy fiber to CA3 synapse / Schaffer collateral - CA1 synapse / cell morphogenesis / ruffle membrane / Z disc / actin filament binding / lamellipodium / regulation of cell shape / actin cytoskeleton organization / postsynaptic density / membrane / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能
Pleckstrin homology domain-containing family O member 1 / Pleckstrin homology domain-containing family O member 1/2 / F-actin capping protein, alpha/beta subunit, N-terminal domain / F-actin capping protein, alpha subunit / F-actin capping protein, beta subunit / F-actin-capping protein subunit beta / F-actin capping protein, beta subunit, conserved site / F-actin-capping protein subunit beta, N-terminal domain / F-actin capping protein, beta subunit / F-actin capping protein beta subunit signature. ...Pleckstrin homology domain-containing family O member 1 / Pleckstrin homology domain-containing family O member 1/2 / F-actin capping protein, alpha/beta subunit, N-terminal domain / F-actin capping protein, alpha subunit / F-actin capping protein, beta subunit / F-actin-capping protein subunit beta / F-actin capping protein, beta subunit, conserved site / F-actin-capping protein subunit beta, N-terminal domain / F-actin capping protein, beta subunit / F-actin capping protein beta subunit signature. / F-actin capping protein, alpha subunit, conserved site / F-actin capping protein alpha subunit signature 1. / F-actin capping protein alpha subunit signature 2. / F-actin-capping protein subunit alpha / F-actin-capping protein subunit alpha/beta / F-actin-capping protein subunit alpha/beta, domain 2 / F-actin capping protein, alpha subunit, domain 1 / F-actin capping protein alpha subunit / Ribosomal protein S3 C-terminal domain / PH domain / Aspartate Aminotransferase, domain 1 / PH domain profile. / Pleckstrin homology domain. / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Pleckstrin homology domain / PH-like domain superfamily / Alpha-Beta Complex / Up-down Bundle / 2-Layer Sandwich / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性
F-actin-capping protein subunit alpha-1 / F-actin-capping protein subunit beta isoforms 1 and 2 / Pleckstrin homology domain-containing family O member 1 類似検索 - 構成要素
A: F-actin-capping protein subunit alpha-1 B: F-actin-capping protein subunit beta isoforms 1 and 2 C: 23mer peptide from Pleckstrin homology domain-containing family O member 1 ヘテロ分子
解像度: 1.9→43.36 Å / Cor.coef. Fo:Fc: 0.948 / Cor.coef. Fo:Fc free: 0.91 / SU B: 4.35 / SU ML: 0.129 / 交差検証法: THROUGHOUT / ESU R: 0.207 / ESU R Free: 0.181 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.26298
2049
5 %
RANDOM
Rwork
0.2131
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obs
0.2157
38533
97.33 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: MASK