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- PDB-3lk4: Crystal structure of CapZ bound to the uncapping motif from CD2AP -
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Basic information
Entry | Database: PDB / ID: 3lk4 | ||||||
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Title | Crystal structure of CapZ bound to the uncapping motif from CD2AP | ||||||
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![]() | PROTEIN BINDING / CapZ / CD2AP / actin filaments / uncapping / actin-filament regulators / protein-protein comple / Actin capping / Actin-binding / Cytoplasm / Cytoskeleton | ||||||
Function / homology | ![]() Advanced glycosylation endproduct receptor signaling / RHOD GTPase cycle / RHOF GTPase cycle / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / COPI-independent Golgi-to-ER retrograde traffic / response to glial cell derived neurotrophic factor / COPI-mediated anterograde transport / negative regulation of small GTPase mediated signal transduction / Factors involved in megakaryocyte development and platelet production / transforming growth factor beta1 production ...Advanced glycosylation endproduct receptor signaling / RHOD GTPase cycle / RHOF GTPase cycle / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / COPI-independent Golgi-to-ER retrograde traffic / response to glial cell derived neurotrophic factor / COPI-mediated anterograde transport / negative regulation of small GTPase mediated signal transduction / Factors involved in megakaryocyte development and platelet production / transforming growth factor beta1 production / localization of cell / Rab protein signal transduction / WASH complex / : / F-actin capping protein complex / negative regulation of transforming growth factor beta1 production / slit diaphragm / negative regulation of filopodium assembly / response to transforming growth factor beta / podocyte differentiation / immunological synapse formation / endothelium development / nerve growth factor signaling pathway / cell-cell adhesion mediated by cadherin / collateral sprouting / protein heterooligomerization / renal albumin absorption / substrate-dependent cell migration, cell extension / membrane organization / cell junction assembly / phosphatidylinositol 3-kinase regulatory subunit binding / cell-cell junction organization / filopodium assembly / barbed-end actin filament capping / actin polymerization or depolymerization / regulation of cell morphogenesis / podosome / regulation of lamellipodium assembly / Nephrin family interactions / lamellipodium assembly / clathrin binding / cortical cytoskeleton / maintenance of blood-brain barrier / nuclear envelope lumen / cell leading edge / glucose import / filamentous actin / brush border / neurotrophin TRK receptor signaling pathway / centriolar satellite / protein secretion / lymph node development / adipose tissue development / stress-activated MAPK cascade / ruffle / cytoskeleton organization / ERK1 and ERK2 cascade / actin filament polymerization / hippocampal mossy fiber to CA3 synapse / phosphatidylinositol 3-kinase/protein kinase B signal transduction / trans-Golgi network membrane / liver development / positive regulation of protein secretion / regulation of actin cytoskeleton organization / actin filament organization / synapse organization / Schaffer collateral - CA1 synapse / protein catabolic process / response to virus / regulation of synaptic plasticity / response to insulin / neuromuscular junction / cell morphogenesis / lipid metabolic process / structural constituent of cytoskeleton / fibrillar center / Z disc / response to wounding / SH3 domain binding / positive regulation of protein localization to nucleus / male gonad development / actin filament binding / cell migration / actin cytoskeleton / late endosome / lamellipodium / T cell receptor signaling pathway / growth cone / actin cytoskeleton organization / protein-containing complex assembly / vesicle / response to oxidative stress / negative regulation of neuron apoptotic process / cell population proliferation / postsynaptic density / cadherin binding / inflammatory response / cell cycle / cell division / axon Similarity search - Function | ||||||
Biological species | ![]() ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Hernandez-Valladares, M. / Kim, T. / Kannan, B. / Tung, A. / Cooper, J.A. / Robinson, R.C. | ||||||
![]() | ![]() Title: Structural characterization of a capping protein interaction motif defines a family of actin filament regulators. Authors: Hernandez-Valladares, M. / Kim, T. / Kannan, B. / Tung, A. / Aguda, A.H. / Larsson, M. / Cooper, J.A. / Robinson, R.C. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 2.5 MB | Display | ![]() |
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PDB format | ![]() | 2.1 MB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 726.5 KB | Display | ![]() |
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Full document | ![]() | 857.7 KB | Display | |
Data in XML | ![]() | 257.3 KB | Display | |
Data in CIF | ![]() | 356.6 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 3lk2SC ![]() 3lk3C S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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