Entry Database : PDB / ID : 2zet Structure visualization Downloads & linksTitle Crystal structure of the small GTPase Rab27B complexed with the Slp homology domain of Slac2-a/melanophilin ComponentsMelanophilin Ras-related protein Rab-27B DetailsKeywords SIGNALING PROTEIN / COMPLEX / GTP-BINDING PROTEIN / GTPASE / G-PROTEIN / RAB / RAB27B / EFFECTOR / MELANOPHILIN / Slp homology domain / Acetylation / Lipoprotein / Membrane / Methylation / Nucleotide-binding / Prenylation / Coiled coil / Metal-binding / Zinc / Zinc-finger / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGIFunction / homology Function and homology informationFunction Domain/homology Component
melanosome localization / RAB geranylgeranylation / RAB GEFs exchange GTP for GDP on RABs / neurotransmitter receptor transport to postsynaptic membrane / Golgi vesicle fusion to target membrane / unconventional myosin complex / zymogen granule membrane / anterograde axonal protein transport / Platelet degranulation / exocytic vesicle ... melanosome localization / RAB geranylgeranylation / RAB GEFs exchange GTP for GDP on RABs / neurotransmitter receptor transport to postsynaptic membrane / Golgi vesicle fusion to target membrane / unconventional myosin complex / zymogen granule membrane / anterograde axonal protein transport / Platelet degranulation / exocytic vesicle / melanocyte differentiation / multivesicular body sorting pathway / myosin V binding / regulation of exocytosis / multivesicular body membrane / Golgi stack / trans-Golgi network transport vesicle / microtubule plus-end binding / endocytic recycling / vesicle docking involved in exocytosis / microtubule organizing center / pigmentation / cortical actin cytoskeleton / myosin binding / exocytosis / positive regulation of exocytosis / synaptic vesicle endocytosis / protein secretion / cilium assembly / protein targeting / stress fiber / axon cytoplasm / small monomeric GTPase / G protein activity / secretory granule / protein localization to plasma membrane / intracellular protein transport / synaptic vesicle membrane / small GTPase binding / GDP binding / melanosome / actin cytoskeleton / late endosome / actin binding / dendritic spine / molecular adaptor activity / apical plasma membrane / protein domain specific binding / GTPase activity / GTP binding / Golgi apparatus / metal ion binding Similarity search - Function Rab effector MyRIP/Melanophilin / Melanophilin, FYVE-related domain / Rab effector MyRIP/melanophilin C-terminus / Rab27a/b / Rab-binding domain / FYVE-type zinc finger / FYVE-type zinc finger / Rab-binding domain profile. / small GTPase Rab1 family profile. / Zinc/RING finger domain, C3HC4 (zinc finger) ... Rab effector MyRIP/Melanophilin / Melanophilin, FYVE-related domain / Rab effector MyRIP/melanophilin C-terminus / Rab27a/b / Rab-binding domain / FYVE-type zinc finger / FYVE-type zinc finger / Rab-binding domain profile. / small GTPase Rab1 family profile. / Zinc/RING finger domain, C3HC4 (zinc finger) / Herpes Virus-1 / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Zinc finger, FYVE/PHD-type / Small GTP-binding protein domain / Zinc finger, RING/FYVE/PHD-type / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 3 Å DetailsAuthors Kukimoto-Niino, M. / Sakamoto, A. / Kanno, E. / Hanawa-Suetsugu, K. / Terada, T. / Shirouzu, M. / Fukuda, M. / Yokoyama, S. / RIKEN Structural Genomics/Proteomics Initiative (RSGI) CitationJournal : Structure / Year : 2008Title : Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases.Authors : Kukimoto-Niino, M. / Sakamoto, A. / Kanno, E. / Hanawa-Suetsugu, K. / Terada, T. / Shirouzu, M. / Fukuda, M. / Yokoyama, S. History Deposition Dec 17, 2007 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Sep 30, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Nov 10, 2021 Group : Database references / Derived calculationsCategory : database_2 / pdbx_struct_conn_angle ... database_2 / pdbx_struct_conn_angle / struct_conn / struct_conn_type / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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