Entry | Database: PDB / ID: 2x0c |
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Title | Crystal Structure of the R7R8 domains of Talin |
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Components | TALIN-1 |
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Keywords | CELL ADHESION / CYTOSKELETON / CELL MEMBRANE / ACTIN / SYNEMIN / INTEGRIN / VINCULIN / CELL PROJECTION |
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Function / homology | Function and homology information
GRB2:SOS provides linkage to MAPK signaling for Integrins / Integrin signaling / p130Cas linkage to MAPK signaling for integrins / Smooth Muscle Contraction / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / MAP2K and MAPK activation / LIM domain binding / Platelet degranulation / vinculin binding / integrin activation ...GRB2:SOS provides linkage to MAPK signaling for Integrins / Integrin signaling / p130Cas linkage to MAPK signaling for integrins / Smooth Muscle Contraction / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / MAP2K and MAPK activation / LIM domain binding / Platelet degranulation / vinculin binding / integrin activation / cell-substrate junction assembly / cortical actin cytoskeleton organization / phosphatidylserine binding / ruffle / phosphatidylinositol binding / integrin-mediated signaling pathway / adherens junction / structural constituent of cytoskeleton / cell-cell adhesion / ruffle membrane / actin filament binding / integrin binding / cytoskeleton / focal adhesion / cell surface / plasma membrane / cytoplasmSimilarity search - Function Talin, central domain / A middle domain of Talin 1 / Alpha-catenin/vinculin-like / : / Talin, R4 domain / Vinculin-binding site-containing domain / Talin, central / Talin, N-terminal F0 domain / Talin, central domain superfamily / Talin-1/2, rod-segment ...Talin, central domain / A middle domain of Talin 1 / Alpha-catenin/vinculin-like / : / Talin, R4 domain / Vinculin-binding site-containing domain / Talin, central / Talin, N-terminal F0 domain / Talin, central domain superfamily / Talin-1/2, rod-segment / Vinculin Binding Site / Talin, middle domain / N-terminal or F0 domain of Talin-head FERM / I/LWEQ domain / I/LWEQ domain superfamily / I/LWEQ domain / I/LWEQ domain profile. / I/LWEQ domain / Phosphotyrosine-binding domain / Alpha-catenin/vinculin-like superfamily / FERM domain signature 1. / FERM conserved site / FERM domain signature 2. / FERM central domain / FERM/acyl-CoA-binding protein superfamily / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Four Helix Bundle (Hemerythrin (Met), subunit A) / PH-like domain superfamily / Ubiquitin-like domain superfamily / Up-down Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | MUS MUSCULUS (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution: 2 Å |
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Authors | Gingras, A.R. / Goult, B.T. / Bate, N. / Barsukov, I.L. / Emsley, J. / Critchely, D.R. |
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Citation | Journal: J.Biol.Chem. / Year: 2010 Title: Central Region of Talin Has a Unique Fold that Binds Vinculin and Actin. Authors: Gingras, A.R. / Bate, N. / Goult, B.T. / Patel, B. / Kopp, P.M. / Emsley, J. / Barsukov, I.L. / Roberts, G.C.K. / Critchley, D.R. |
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History | Deposition | Dec 8, 2009 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 7, 2010 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | Mar 1, 2023 | Group: Database references / Other / Structure summary / Category: database_2 / pdbx_database_status / struct Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct.title |
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Revision 1.3 | Jun 19, 2024 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond |
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