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- PDB-2vxw: Structural and Functional Studies of the Potent Anti-HIV Chemokin... -
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Open data
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Basic information
Entry | Database: PDB / ID: 2vxw | ||||||
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Title | Structural and Functional Studies of the Potent Anti-HIV Chemokine Variant P2-RANTES | ||||||
![]() | C-C MOTIF CHEMOKINE 5![]() | ||||||
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Function / homology | ![]() regulation of chronic inflammatory response / CCR4 chemokine receptor binding / chemokine receptor antagonist activity / activation of phospholipase D activity / positive regulation of cellular biosynthetic process / CCR1 chemokine receptor binding / positive regulation of natural killer cell chemotaxis / negative regulation of macrophage apoptotic process / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() | ||||||
![]() | Jin, H. / Li, P. / LiWang, P.J. | ||||||
![]() | ![]() Title: Structural and Functional Studies of the Potent Anti-HIV Chemokine Variant P2-Rantes. Authors: Jin, H. / Kagiampakis, I. / Li, P. / Liwang, P.J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 67.2 KB | Display | ![]() |
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PDB format | ![]() | 54 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 7918.121 Da / Num. of mol.: 4 / Fragment: CHEMOKINE, RESIDUES 33-91 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() #2: Water | ChemComp-HOH / | ![]() |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.43 Å3/Da / Density % sol: 48.9 % / Description: NONE |
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Crystal grow![]() | pH: 5.5 / Details: pH 5.5 |
-Data collection
Diffraction | Mean temperature: 287 K |
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Diffraction source | Source: ![]() |
Detector | Type: RIGAKU MICROMAX |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 1.7→50 Å / Num. obs: 34463 / % possible obs: 97.4 % / Observed criterion σ(I): 2 / Redundancy: 3.4 % / Biso Wilson estimate: 17.3 Å2 / Rmerge(I) obs: 0.05 / Net I/σ(I): 12 |
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Processing
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Refinement | Method to determine structure![]() Starting model: NONE Resolution: 1.7→50 Å / Rfactor Rfree error: 0.017 / Data cutoff high absF: 10000 / Cross valid method: THROUGHOUT / σ(F): 0
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Solvent computation | Bsol: 65.9606 Å2 / ksol: 0.341826 e/Å3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 16.8 Å2
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Refine analyze |
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Refinement step | Cycle: LAST / Resolution: 1.7→50 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 2→2.12 Å / Rfactor Rfree error: 0.042 / Total num. of bins used: 6
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Xplor file |
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