Entry Database : PDB / ID : 2toh Structure visualization Downloads & linksTitle TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT ComponentsTYROSINE 3-MONOOXYGENASE Tyrosine hydroxylase Details Keywords HYDROXYLASE / NEUROTRANSMITTER BIOSYNTHESIS / NON-HEME IRON / PTERIN CO-SUBSTRATE / CATECHOLAMINE BIOSYNTHESIS / OXIDOREDUCTASEFunction / homology Function and homology informationFunction Domain/homology Component
Catecholamine biosynthesis / tyrosine 3-monooxygenase / tyrosine 3-monooxygenase activity / phytoalexin metabolic process / dopamine biosynthetic process from tyrosine / phthalate metabolic process / glycoside metabolic process / terpene metabolic process / isoquinoline alkaloid metabolic process / response to insecticide ... Catecholamine biosynthesis / tyrosine 3-monooxygenase / tyrosine 3-monooxygenase activity / phytoalexin metabolic process / dopamine biosynthetic process from tyrosine / phthalate metabolic process / glycoside metabolic process / terpene metabolic process / isoquinoline alkaloid metabolic process / response to insecticide / norepinephrine biosynthetic process / aminergic neurotransmitter loading into synaptic vesicle / hyaloid vascular plexus regression / embryonic camera-type eye morphogenesis / circadian sleep/wake cycle / epinephrine biosynthetic process / dopamine binding / catecholamine biosynthetic process / response to pyrethroid / response to isolation stress / eye photoreceptor cell development / melanosome membrane / response to ether / sphingolipid metabolic process / response to growth factor / synaptic transmission, dopaminergic / tetrahydrobiopterin binding / response to metal ion / response to herbicide / mating behavior / dopamine biosynthetic process / response to steroid hormone / regulation of heart contraction / amino acid binding / eating behavior / response to corticosterone / response to zinc ion / cellular response to alkaloid / smooth endoplasmic reticulum / small molecule binding / social behavior / response to light stimulus / response to immobilization stress / cellular response to manganese ion / response to electrical stimulus / response to salt stress / response to amphetamine / visual perception / response to nutrient levels / ferric iron binding / fatty acid metabolic process / locomotory behavior / response to activity / response to nicotine / learning / cellular response to glucose stimulus / monooxygenase activity / ferrous iron binding / animal organ morphogenesis / cytoplasmic vesicle membrane / terminal bouton / cytoplasmic side of plasma membrane / response to organic cyclic compound / memory / response to peptide hormone / cerebral cortex development / cellular response to growth factor stimulus / cognition / oxygen binding / cellular response to nicotine / cellular response to xenobiotic stimulus / synaptic vesicle / response to estradiol / heart development / perikaryon / cytoplasmic vesicle / response to ethanol / response to lipopolysaccharide / response to hypoxia / neuron projection / response to xenobiotic stimulus / axon / protein domain specific binding / neuronal cell body / dendrite / perinuclear region of cytoplasm / enzyme binding / mitochondrion / identical protein binding / nucleus / cytoplasm Similarity search - Function Tyrosine 3-monooxygenase / Tyrosine hydroxylase, conserved site / Tyrosine 3-monooxygenase, catalytic domain / : / Tyrosine hydroxylase N terminal / Tyrosine 3-monooxygenase-like, ACT domain / Phenylalanine Hydroxylase / Aromatic amino acid hydroxylase / Tyrosine 3-monooxygenase-like / Aromatic amino acid hydroxylase, iron/copper binding site ... Tyrosine 3-monooxygenase / Tyrosine hydroxylase, conserved site / Tyrosine 3-monooxygenase, catalytic domain / : / Tyrosine hydroxylase N terminal / Tyrosine 3-monooxygenase-like, ACT domain / Phenylalanine Hydroxylase / Aromatic amino acid hydroxylase / Tyrosine 3-monooxygenase-like / Aromatic amino acid hydroxylase, iron/copper binding site / Biopterin-dependent aromatic amino acid hydroxylases signature. / Aromatic amino acid hydroxylase / Aromatic amino acid hydroxylase, C-terminal / Aromatic amino acid monoxygenase, C-terminal domain superfamily / Aromatic amino acid hydroxylase superfamily / Biopterin-dependent aromatic amino acid hydroxylase / Biopterin-dependent aromatic amino acid hydroxylase family profile. / ACT-like domain / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.3 Å DetailsAuthors Goodwill, K.E. / Sabatier, C. / Stevens, R.C. CitationJournal : Biochemistry / Year : 1998Title : Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site.Authors : Goodwill, K.E. / Sabatier, C. / Stevens, R.C. History Deposition Aug 26, 1998 Processing site : BNLRevision 1.0 Aug 26, 1999 Provider : repository / Type : Initial releaseRevision 1.1 Mar 25, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Derived calculations / Version format complianceRevision 1.3 Apr 3, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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