Entry | Database: PDB / ID: 2rup |
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Title | Solution structure of rat P2X4 receptor head domain |
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Components | P2X purinoceptor 4 |
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Keywords | TRANSPORT PROTEIN / P2X4 receptor / head domain / CANION TRANSPORT / METAL ION BINDING |
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Function / homology | Function and homology information
Platelet homeostasis / sensory perception of touch / Elevation of cytosolic Ca2+ levels / purinergic nucleotide receptor activity / extracellularly ATP-gated monoatomic cation channel activity / positive regulation of microglial cell migration / purinergic nucleotide receptor signaling pathway / negative regulation of cardiac muscle hypertrophy / response to fluid shear stress / ligand-gated calcium channel activity ...Platelet homeostasis / sensory perception of touch / Elevation of cytosolic Ca2+ levels / purinergic nucleotide receptor activity / extracellularly ATP-gated monoatomic cation channel activity / positive regulation of microglial cell migration / purinergic nucleotide receptor signaling pathway / negative regulation of cardiac muscle hypertrophy / response to fluid shear stress / ligand-gated calcium channel activity / ATP-gated ion channel activity / regulation of chemotaxis / inorganic cation transmembrane transport / parallel fiber to Purkinje cell synapse / relaxation of cardiac muscle / cellular response to zinc ion / positive regulation of endothelial cell chemotaxis / cellular response to ATP / response to ATP / positive regulation of calcium ion transport into cytosol / behavioral response to pain / ligand-gated monoatomic cation channel activity / membrane depolarization / neuronal action potential / regulation of cardiac muscle contraction / response to axon injury / positive regulation of blood vessel endothelial cell migration / regulation of sodium ion transport / monoatomic ion transmembrane transport / sensory perception of pain / nitric oxide biosynthetic process / positive regulation of calcium-mediated signaling / excitatory postsynaptic potential / response to ischemia / apoptotic signaling pathway / calcium ion transmembrane transport / postsynaptic density membrane / regulation of blood pressure / vasodilation / terminal bouton / cell junction / calcium ion transport / apical part of cell / cell body / dendritic spine / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cadherin binding / copper ion binding / axon / lysosomal membrane / signaling receptor binding / neuronal cell body / glutamatergic synapse / dendrite / perinuclear region of cytoplasm / signal transduction / zinc ion binding / ATP binding / identical protein binding / membrane / plasma membraneSimilarity search - Function P2X4 purinoceptor / ATP P2X receptor / ATP P2X receptors signature. / P2X purinoreceptor / P2X purinoreceptor extracellular domain superfamilySimilarity search - Domain/homology |
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Biological species | Rattus norvegicus (Norway rat) |
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Method | SOLUTION NMR / torsion angle dynamics |
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Model details | lowest energy, model1 |
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Authors | Abe, Y. / Igawa, T. / Tsuda, M. / Inoue, K. / Ueda, T. |
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Citation | Journal: FEBS Lett. / Year: 2015 Title: Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding Authors: Igawa, T. / Abe, Y. / Tsuda, M. / Inoue, K. / Ueda, T. |
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History | Deposition | Nov 12, 2014 | Deposition site: BMRB / Processing site: PDBJ |
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Revision 1.0 | Feb 4, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 17, 2018 | Group: Data collection / Database references / Category: citation Item: _citation.journal_abbrev / _citation.journal_id_ISSN ..._citation.journal_abbrev / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed |
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Revision 1.2 | Dec 11, 2019 | Group: Advisory / Database references / Derived calculations Category: pdbx_validate_close_contact / struct_conn / struct_ref_seq_dif Item: _struct_ref_seq_dif.details |
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Revision 1.3 | Jun 14, 2023 | Group: Database references / Other / Category: database_2 / pdbx_database_status Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data |
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