登録情報 データベース : PDB / ID : 2pr9 構造の表示 ダウンロードとリンクタイトル Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2 subunit-derived internalization peptide DEEYGYECL 要素AP-2 complex subunit mu-1 GABA(A) receptor subunit gamma-2 peptide 詳細キーワード ENDOCYTOSIS / adaptor / internalization peptide complex / inhibitory neurotransmitter receptor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
GABA receptor activation / inhibitory extracellular ligand-gated monoatomic ion channel activity / Gap junction degradation / Formation of annular gap junctions / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / LDL clearance / VLDLR internalisation and degradation / Retrograde neurotrophin signalling / chemical synaptic transmission, postsynaptic / WNT5A-dependent internalization of FZD4 ... GABA receptor activation / inhibitory extracellular ligand-gated monoatomic ion channel activity / Gap junction degradation / Formation of annular gap junctions / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / LDL clearance / VLDLR internalisation and degradation / Retrograde neurotrophin signalling / chemical synaptic transmission, postsynaptic / WNT5A-dependent internalization of FZD4 / extrinsic component of presynaptic endocytic zone membrane / MHC class II antigen presentation / inhibitory synapse / AP-2 adaptor complex / regulation of vesicle size / postsynaptic neurotransmitter receptor internalization / GABA receptor complex / Recycling pathway of L1 / cellular response to histamine / GABA-A receptor activity / GABA-gated chloride ion channel activity / GABA-A receptor complex / Cargo recognition for clathrin-mediated endocytosis / positive regulation of synaptic vesicle endocytosis / Clathrin-mediated endocytosis / clathrin adaptor activity / inhibitory synapse assembly / vesicle budding from membrane / clathrin-dependent endocytosis / signal sequence binding / synaptic transmission, GABAergic / gamma-aminobutyric acid signaling pathway / postsynaptic specialization membrane / negative regulation of protein localization to plasma membrane / chloride transport / low-density lipoprotein particle receptor binding / adult behavior / chloride channel activity / Trafficking of GluR2-containing AMPA receptors / chloride channel complex / positive regulation of receptor internalization / synaptic vesicle endocytosis / transmembrane transporter complex / GABA-ergic synapse / regulation of postsynaptic membrane potential / clathrin-coated pit / monoatomic ion transmembrane transport / chloride transmembrane transport / dendrite membrane / post-embryonic development / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / intracellular protein transport / cytoplasmic vesicle membrane / terminal bouton / receptor internalization / disordered domain specific binding / cytoplasmic vesicle / protein-containing complex assembly / chemical synaptic transmission / postsynapse / transmembrane transporter binding / neuron projection / axon / lipid binding / glutamatergic synapse / synapse / plasma membrane 類似検索 - 分子機能 Mu homology domain, subdomain B / Mu2, C-terminal domain / AP-2 complex subunit mu, N-terminal / Gamma-aminobutyric-acid A receptor, gamma 2 subunit / Gamma-aminobutyric acid receptor subunit gamma-1/4 / Clathrin adaptor complexes medium chain signature 1. / Clathrin adaptor, mu subunit / Clathrin adaptor, mu subunit, conserved site / Clathrin adaptor complexes medium chain signature 2. / Adaptor complexes medium subunit family ... Mu homology domain, subdomain B / Mu2, C-terminal domain / AP-2 complex subunit mu, N-terminal / Gamma-aminobutyric-acid A receptor, gamma 2 subunit / Gamma-aminobutyric acid receptor subunit gamma-1/4 / Clathrin adaptor complexes medium chain signature 1. / Clathrin adaptor, mu subunit / Clathrin adaptor, mu subunit, conserved site / Clathrin adaptor complexes medium chain signature 2. / Adaptor complexes medium subunit family / AP complex, mu/sigma subunit / Clathrin adaptor complex small chain / AP-2 complex subunit mu, C-terminal superfamily / Mu homology domain / Mu homology domain (MHD) profile. / Longin-like domain superfamily / Gamma-aminobutyric acid A receptor/Glycine receptor alpha / Neurotransmitter-gated ion-channel, conserved site / Neurotransmitter-gated ion-channels signature. / Neurotransmitter-gated ion-channel transmembrane domain / Neurotransmitter-gated ion-channel transmembrane region / Neurotransmitter-gated ion-channel transmembrane domain superfamily / Neuronal acetylcholine receptor / Neurotransmitter-gated ion-channel / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel ligand-binding domain superfamily / Neurotransmitter-gated ion-channel ligand binding domain / Immunoglobulin-like / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性 Gamma-aminobutyric acid receptor subunit gamma-2 / AP-2 complex subunit mu 類似検索 - 構成要素生物種 Rattus norvegicus (ドブネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.51 Å 詳細データ登録者 Vahedi-Faridi, A. / Haucke, V. / Kittler, J.T. / Kukhtina, V. / Moss, S.J. / Saenger, W. / Chen, G.-J. / Tretter, V. / Smith, K. / Yan, Z. ...Vahedi-Faridi, A. / Haucke, V. / Kittler, J.T. / Kukhtina, V. / Moss, S.J. / Saenger, W. / Chen, G.-J. / Tretter, V. / Smith, K. / Yan, Z. / McAinsh, K. / Arancibia-Carcamo, L. 引用ジャーナル : Proc.Natl.Acad.Sci.Usa / 年 : 2008タイトル : Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.著者 : Kittler, J.T. / Chen, G. / Kukhtina, V. / Vahedi-Faridi, A. / Gu, Z. / Tretter, V. / Smith, K.R. / McAinsh, K. / Arancibia-Carcamo, I.L. / Saenger, W. / Haucke, V. / Yan, Z. / Moss, S.J. 履歴 登録 2007年5月4日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2008年3月18日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Advisory / Version format compliance改定 1.2 2023年8月30日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
すべて表示 表示を減らす Remark 300 BIOMOLECULE THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 2 CHAIN(S). ... BIOMOLECULE THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 2 CHAIN(S). AUTHORS STATE THAT THE BIOLOGICAL MOLECULE FOR THE PROTEIN IS UNKNOWN.