登録情報 | データベース: PDB / ID: 2p33 |
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タイトル | Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors |
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要素 | c-Jun N-terminal kinase 3 |
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キーワード | TRANSFERASE / JNK3 kinase / inhibitor |
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機能・相同性 | 機能・相同性情報
JUN kinase activity / Activation of the AP-1 family of transcription factors / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / response to light stimulus / mitogen-activated protein kinase / JNK cascade / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / regulation of circadian rhythm / FCERI mediated MAPK activation ...JUN kinase activity / Activation of the AP-1 family of transcription factors / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / response to light stimulus / mitogen-activated protein kinase / JNK cascade / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / regulation of circadian rhythm / FCERI mediated MAPK activation / cellular senescence / rhythmic process / Oxidative Stress Induced Senescence / protein phosphorylation / protein serine kinase activity / signal transduction / mitochondrion / nucleoplasm / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Mitogen-activated protein (MAP) kinase, JNK / : / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 ...Mitogen-activated protein (MAP) kinase, JNK / : / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-J07 / Mitogen-activated protein kinase 10類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Ceska, T.A. / Platt, A. / Fortunato, M. / Dickson, K.M. / Sharpe, A. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2007 タイトル: Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors 著者: Alam, M. / Beevers, R.E. / Ceska, T. / Davenport, R.J. / Dickson, K.M. / Fortunato, M. / Gowers, L. / Haughan, A.F. / James, L.A. / Jones, M.W. / Kinsella, N. / Lowe, C. / Meissner, J.W. / ...著者: Alam, M. / Beevers, R.E. / Ceska, T. / Davenport, R.J. / Dickson, K.M. / Fortunato, M. / Gowers, L. / Haughan, A.F. / James, L.A. / Jones, M.W. / Kinsella, N. / Lowe, C. / Meissner, J.W. / Nicolas, A.L. / Perry, B.G. / Phillips, D.J. / Pitt, W.R. / Platt, A. / Ratcliffe, A.J. / Sharpe, A. / Tait, L.J. |
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履歴 | 登録 | 2007年3月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年6月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2017年10月18日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.4 | 2023年8月30日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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