登録情報 | データベース: PDB / ID: 2oz4 |
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タイトル | Structural Plasticity in IgSF Domain 4 of ICAM-1 Mediates Cell Surface Dimerization |
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要素 | - FAB FRAGMENT LIGHT CHAIN
- FAB FRAGMENT, HEAVY CHAIN
- Intercellular adhesion molecule 1
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キーワード | CELL ADHESION / IGSF DOMAIN / STRUCTURAL PLASTICITY / CELL-SURFACE DIMERIZATION |
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機能・相同性 | 機能・相同性情報
response to sulfur dioxide / response to gonadotropin / : / regulation of leukocyte mediated cytotoxicity / T cell extravasation / positive regulation of cellular extravasation / regulation of ruffle assembly / establishment of Sertoli cell barrier / T cell antigen processing and presentation / T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ...response to sulfur dioxide / response to gonadotropin / : / regulation of leukocyte mediated cytotoxicity / T cell extravasation / positive regulation of cellular extravasation / regulation of ruffle assembly / establishment of Sertoli cell barrier / T cell antigen processing and presentation / T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / acute inflammatory response to antigenic stimulus / membrane to membrane docking / establishment of endothelial intestinal barrier / response to xenobiotic stimulus => GO:0009410 / adhesion of symbiont to host / positive regulation of B cell activation / phagocytosis, recognition / cellular response to interleukin-6 / establishment of endothelial barrier / response to copper ion / positive regulation of leukocyte adhesion to vascular endothelial cell / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / cell adhesion mediated by integrin / leukocyte cell-cell adhesion / response to ionizing radiation / phagocytosis, engulfment / positive regulation of actin filament polymerization / leukocyte migration / cellular response to alkaloid / plasma membrane => GO:0005886 / Interleukin-10 signaling / cellular response to nutrient levels / negative regulation of calcium ion transport / immunological synapse / regulation of immune response / response to amino acid / cellular response to interleukin-1 / Integrin cell surface interactions / negative regulation of endothelial cell apoptotic process / type II interferon-mediated signaling pathway / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / ovarian follicle development / positive regulation of vasoconstriction / immunoglobulin complex, circulating / immunoglobulin receptor binding / response to amphetamine / cellular response to dexamethasone stimulus / extracellular matrix organization / positive regulation of GTPase activity / cellular response to leukemia inhibitory factor / complement activation, classical pathway / cellular response to glucose stimulus / sensory perception of sound / antigen binding / B cell receptor signaling pathway / response to insulin / cytokine-mediated signaling pathway / cellular response to amyloid-beta / transmembrane signaling receptor activity / positive regulation of peptidyl-tyrosine phosphorylation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Interferon gamma signaling / positive regulation of nitric oxide biosynthetic process / integrin binding / virus receptor activity / cellular response to tumor necrosis factor / signaling receptor activity / positive regulation of NF-kappaB transcription factor activity / regulation of cell shape / cellular response to hypoxia / cellular response to lipopolysaccharide / Interleukin-4 and Interleukin-13 signaling / response to ethanol / collagen-containing extracellular matrix / receptor-mediated virion attachment to host cell / positive regulation of ERK1 and ERK2 cascade / cell adhesion / defense response to bacterium / membrane raft / external side of plasma membrane / innate immune response / focal adhesion / cell surface / extracellular space / extracellular exosome / membrane / plasma membrane類似検索 - 分子機能 : / ICAM-1/3/5, D2 domain / Intercellular adhesion molecule / Intercellular adhesion molecule, N-terminal / : / Intercellular adhesion molecule (ICAM), N-terminal domain / Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal / Immunoglobulin domain / Immunoglobulin V-Type / Immunoglobulin V-set domain ...: / ICAM-1/3/5, D2 domain / Intercellular adhesion molecule / Intercellular adhesion molecule, N-terminal / : / Intercellular adhesion molecule (ICAM), N-terminal domain / Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal / Immunoglobulin domain / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Ig heavy chain V region J558 / Intercellular adhesion molecule 1 / : / Intercellular adhesion molecule 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.7 Å |
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データ登録者 | Chen, X. / Kim, T.D. / Carman, C.V. / Mi, L. / Song, G. / Springer, T.A. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.Usa / 年: 2007 タイトル: Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization. 著者: Chen, X. / Kim, T.D. / Carman, C.V. / Mi, L.Z. / Song, G. / Springer, T.A. |
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履歴 | 登録 | 2007年2月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年10月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
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改定 2.0 | 2020年7月29日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / pdbx_struct_special_symmetry / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.auth_asym_id / _atom_site.auth_seq_id ..._atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.src_method / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.value / _pdbx_struct_special_symmetry.label_asym_id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2023年8月30日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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