登録情報 データベース : PDB / ID : 2m68 構造の表示 ダウンロードとリンクタイトル NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only) 要素Insulin-like growth factor 2 receptor variant 詳細 キーワード ANTITUMOR PROTEIN / antitumor / directed evolution / high affinity機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Retrograde transport at the Trans-Golgi-Network / clathrin coat / retromer complex binding / response to tetrachloromethane / insulin-like growth factor receptor activity / insulin-like growth factor binding / insulin-like growth factor II binding / trans-Golgi network transport vesicle / positive regulation by host of viral process / retinoic acid binding ... Retrograde transport at the Trans-Golgi-Network / clathrin coat / retromer complex binding / response to tetrachloromethane / insulin-like growth factor receptor activity / insulin-like growth factor binding / insulin-like growth factor II binding / trans-Golgi network transport vesicle / positive regulation by host of viral process / retinoic acid binding / lysosomal transport / Golgi Associated Vesicle Biogenesis / nuclear envelope lumen / D-mannose binding / endocytic vesicle / G-protein alpha-subunit binding / animal organ regeneration / response to retinoic acid / transport vesicle / receptor-mediated endocytosis / secretory granule membrane / post-embryonic development / liver development / trans-Golgi network membrane / clathrin-coated endocytic vesicle membrane / phosphoprotein binding / trans-Golgi network / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / late endosome / signaling receptor activity / spermatogenesis / endosome / endosome membrane / early endosome / positive regulation of apoptotic process / G protein-coupled receptor signaling pathway / Golgi membrane / focal adhesion / Neutrophil degranulation / perinuclear region of cytoplasm / enzyme binding / cell surface / Golgi apparatus / signal transduction / extracellular exosome / identical protein binding / membrane / plasma membrane 類似検索 - 分子機能 Cation-independent mannose-6-phosphate receptor repeat / Cation-dependent Mannose-6-phosphate Receptor; Chain A / Mannose-6-phosphate receptor binding domain / Cation-independent mannose-6-phosphate receptor repeat / Cation-independent mannose-6-phosphate receptor repeat / MRH domain / MRH domain profile. / Mannose-6-phosphate receptor binding domain superfamily / Fibronectin type II domain / Fibronectin type II domain superfamily ... Cation-independent mannose-6-phosphate receptor repeat / Cation-dependent Mannose-6-phosphate Receptor; Chain A / Mannose-6-phosphate receptor binding domain / Cation-independent mannose-6-phosphate receptor repeat / Cation-independent mannose-6-phosphate receptor repeat / MRH domain / MRH domain profile. / Mannose-6-phosphate receptor binding domain superfamily / Fibronectin type II domain / Fibronectin type II domain superfamily / Fibronectin type II domain / Fibronectin type-II collagen-binding domain signature. / Fibronectin type-II collagen-binding domain profile. / Fibronectin type 2 domain / Kringle-like fold / Distorted Sandwich / Mainly Beta 類似検索 - ドメイン・相同性 Cation-independent mannose-6-phosphate receptor / Insulin-like growth factor 2 receptor variant 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / DGSA-distance geometry simulated annealing 詳細Model details fewest violations, model1 データ登録者 Strickland, M. / Williams, C. / Richards, E. / Minnall, L. / Crump, M.P. / Frago, S. / Hughes, J. / Garner, L. / Hoppe, H. / Rezgui, D. ...Strickland, M. / Williams, C. / Richards, E. / Minnall, L. / Crump, M.P. / Frago, S. / Hughes, J. / Garner, L. / Hoppe, H. / Rezgui, D. / Zaccheo, O.J. / Prince, S.N. / Hassan, A.B. / Whittaker, S. 引用ジャーナル : Proc.Natl.Acad.Sci.USA / 年 : 2016タイトル : Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.著者: Frago, S. / Nicholls, R.D. / Strickland, M. / Hughes, J. / Williams, C. / Garner, L. / Surakhy, M. / Maclean, R. / Rezgui, D. / Prince, S.N. / Zaccheo, O.J. / Ebner, D. / Sanegre, S. / Yu, S. ... 著者 : Frago, S. / Nicholls, R.D. / Strickland, M. / Hughes, J. / Williams, C. / Garner, L. / Surakhy, M. / Maclean, R. / Rezgui, D. / Prince, S.N. / Zaccheo, O.J. / Ebner, D. / Sanegre, S. / Yu, S. / Buffa, F.M. / Crump, M.P. / Hassan, A.B. 履歴 登録 2013年3月27日 登録サイト : BMRB / 処理サイト : RCSB改定 1.0 2014年10月15日 Provider : repository / タイプ : Initial release改定 1.1 2016年5月4日 Group : Database references改定 1.2 2016年5月18日 Group : Database references改定 1.3 2016年6月1日 Group : Database references改定 1.4 2023年6月14日 Group : Data collection / Database references / Otherカテゴリ : database_2 / pdbx_database_status ... database_2 / pdbx_database_status / pdbx_nmr_software / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_software.name / _struct_ref_seq_dif.details
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