登録情報 | データベース: PDB / ID: 2ltz |
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タイトル | Smurf2 WW3 domain in complex with a Smad7 derived peptide |
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要素 | - E3 ubiquitin-protein ligase SMURF2
- Smad7 derived peptide
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キーワード | PROTEIN BINDING/PEPTIDE / WW / SMURF2 / SMAD7 / PROTEIN BINDING-PEPTIDE complex |
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機能・相同性 | 機能・相同性情報
positive regulation of chondrocyte hypertrophy / negative regulation of T-helper 17 type immune response / negative regulation of chondrocyte proliferation / negative regulation of T cell cytokine production / heteromeric SMAD protein complex / regulation of ventricular cardiac muscle cell membrane depolarization / negative regulation of T-helper 17 cell differentiation / regulation of transforming growth factor beta receptor signaling pathway / positive regulation of cell-cell adhesion / response to laminar fluid shear stress ...positive regulation of chondrocyte hypertrophy / negative regulation of T-helper 17 type immune response / negative regulation of chondrocyte proliferation / negative regulation of T cell cytokine production / heteromeric SMAD protein complex / regulation of ventricular cardiac muscle cell membrane depolarization / negative regulation of T-helper 17 cell differentiation / regulation of transforming growth factor beta receptor signaling pathway / positive regulation of cell-cell adhesion / response to laminar fluid shear stress / positive regulation of trophoblast cell migration / regulation of epithelial to mesenchymal transition / activin receptor binding / negative regulation of transcription by competitive promoter binding / negative regulation of ubiquitin-protein transferase activity / Signaling by BMP / type I transforming growth factor beta receptor binding / SMAD protein signal transduction / negative regulation of activin receptor signaling pathway / adherens junction assembly / HECT-type E3 ubiquitin transferase / protein-containing complex localization / negative regulation of epithelial to mesenchymal transition / I-SMAD binding / negative regulation of ossification / transcription regulator inhibitor activity / Wnt signaling pathway, planar cell polarity pathway / ventricular cardiac muscle tissue morphogenesis / artery morphogenesis / ureteric bud development / ventricular septum morphogenesis / negative regulation of SMAD protein signal transduction / negative regulation of peptidyl-threonine phosphorylation / SMAD binding / negative regulation of peptidyl-serine phosphorylation / negative regulation of BMP signaling pathway / regulation of cardiac muscle contraction / ubiquitin-like ligase-substrate adaptor activity / anatomical structure morphogenesis / ubiquitin ligase complex / negative regulation of protein ubiquitination / cellular response to transforming growth factor beta stimulus / collagen binding / transforming growth factor beta receptor signaling pathway / Downregulation of TGF-beta receptor signaling / negative regulation of cell migration / Asymmetric localization of PCP proteins / cellular response to leukemia inhibitory factor / Degradation of AXIN / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / negative regulation of transforming growth factor beta receptor signaling pathway / Hedgehog 'on' state / Regulation of RUNX3 expression and activity / fibrillar center / beta-catenin binding / ubiquitin-protein transferase activity / transcription corepressor activity / UCH proteinases / Interferon gamma signaling / ubiquitin protein ligase activity / positive regulation of canonical Wnt signaling pathway / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Antigen processing: Ubiquitination & Proteasome degradation / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / cell differentiation / protein stabilization / Ub-specific processing proteases / protein ubiquitination / nuclear speck / membrane raft / negative regulation of DNA-templated transcription / centrosome / ubiquitin protein ligase binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / identical protein binding / nucleus / metal ion binding / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain ...MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / E3 ubiquitin-protein ligase, SMURF1 type / SMAD-like domain superfamily / : / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / C2 domain / Protein kinase C conserved region 2 (CalB) / SMAD/FHA domain superfamily / WW domain / WW/rsp5/WWP domain signature. / C2 domain / C2 domain profile. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / C2 domain superfamily類似検索 - ドメイン・相同性 Mothers against decapentaplegic homolog 7 / E3 ubiquitin-protein ligase SMURF2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics |
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データ登録者 | Macias, M.J. / Aragon, E. / Goerner, N. / Xi, Q. / Lopes, T. / Gao, S. / Massague, J. |
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引用 | ジャーナル: Structure / 年: 2012 タイトル: Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways. 著者: Aragon, E. / Goerner, N. / Xi, Q. / Gomes, T. / Gao, S. / Massague, J. / Macias, M.J. |
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履歴 | 登録 | 2012年6月4日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2012年11月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model |
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