登録情報 | データベース: PDB / ID: 2l27 |
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タイトル | NMR Structure of the ECD1 of CRF-R1 in complex with a peptide agonist |
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要素 | - Corticotropin-releasing factor receptor 1
- peptide agonist
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キーワード | MEMBRANE PROTEIN / Peptide binding protein / CRF / ECD1 / Agonist / Family B1 / Alpha helical CRF |
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機能・相同性 | 機能・相同性情報
regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway / corticotropin-releasing hormone binding / regulation of corticosterone secretion / corticotrophin-releasing factor receptor activity / corticotropin-releasing hormone receptor activity / corticotropin secretion / general adaptation syndrome, behavioral process / parturition / cellular response to corticotropin-releasing hormone stimulus / negative regulation of voltage-gated calcium channel activity ...regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway / corticotropin-releasing hormone binding / regulation of corticosterone secretion / corticotrophin-releasing factor receptor activity / corticotropin-releasing hormone receptor activity / corticotropin secretion / general adaptation syndrome, behavioral process / parturition / cellular response to corticotropin-releasing hormone stimulus / negative regulation of voltage-gated calcium channel activity / behavioral response to ethanol / fear response / G protein-coupled peptide receptor activity / Class B/2 (Secretin family receptors) / exploration behavior / adrenal gland development / activation of adenylate cyclase activity / female pregnancy / adenylate cyclase-activating G protein-coupled receptor signaling pathway / G alpha (s) signalling events / cell surface receptor signaling pathway / endosome / neuron projection / immune response / membrane / plasma membrane類似検索 - 分子機能 GPCR, family 2, corticotropin releasing factor receptor, type 1 / GPCR, family 2, corticotropin releasing factor receptor / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily ...GPCR, family 2, corticotropin releasing factor receptor, type 1 / GPCR, family 2, corticotropin releasing factor receptor / GPCR, family 2, extracellular hormone receptor domain / Hormone receptor fold / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Few Secondary Structures / Irregular類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics |
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Model details | lowest energy, model 1 |
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データ登録者 | Grace, C.R.R. / Perrin, M.H. / Gulyas, J.R.R. / Rivier, J.E. / Vale, W.W. / Riek, R.R. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2010 タイトル: NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist. 著者: Grace, C.R. / Perrin, M.H. / Gulyas, J. / Rivier, J.E. / Vale, W.W. / Riek, R. |
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履歴 | 登録 | 2010年8月12日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2010年9月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2017年3月1日 | Group: Database references |
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