登録情報 | データベース: PDB / ID: 2kie |
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タイトル | A PH domain within OCRL bridges clathrin mediated membrane trafficking to phosphoinositide metabolis |
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要素 | Inositol polyphosphate 5-phosphatase OCRL-1 |
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キーワード | HYDROLASE (加水分解酵素) / OCRL / INPP5B / PH / clathrin (クラスリン) / endocytosis (エンドサイトーシス) / Alternative splicing (選択的スプライシング) / Cataract (白内障) / Disease mutation |
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機能・相同性 | 機能・相同性情報
phosphatidylinositol phosphate 4-phosphatase activity / inositol phosphate phosphatase activity / phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity / Synthesis of IP2, IP, and Ins in the cytosol / inositol phosphate metabolic process / inositol-polyphosphate 5-phosphatase / inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity / ホスファチジルイノシトール-3,4,5-三リン酸 5-ホスファターゼ / inositol-1,4,5-trisphosphate 5-phosphatase activity / inositol-polyphosphate 5-phosphatase activity ...phosphatidylinositol phosphate 4-phosphatase activity / inositol phosphate phosphatase activity / phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity / Synthesis of IP2, IP, and Ins in the cytosol / inositol phosphate metabolic process / inositol-polyphosphate 5-phosphatase / inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity / ホスファチジルイノシトール-3,4,5-三リン酸 5-ホスファターゼ / inositol-1,4,5-trisphosphate 5-phosphatase activity / inositol-polyphosphate 5-phosphatase activity / ホスホイノシチド-5-ホスファターゼ / Synthesis of PIPs at the Golgi membrane / phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity / phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity / ゴルジ体 / phosphatidylinositol dephosphorylation / membrane organization / phosphatidylinositol biosynthetic process / クラスリン / Golgi-associated vesicle / Golgi Associated Vesicle Biogenesis / RHOJ GTPase cycle / Synthesis of IP3 and IP4 in the cytosol / Synthesis of PIPs at the plasma membrane / cilium assembly / photoreceptor outer segment / RAC3 GTPase cycle / クラスリン / GTPase activator activity / ゴルジ体 / lipid metabolic process / small GTPase binding / phagocytic vesicle membrane / Clathrin-mediated endocytosis / early endosome membrane / in utero embryonic development / リソソーム / エンドソーム / シグナル伝達 / 生体膜 / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 PH-domain like - #110 / Inositol polyphosphate 5-phosphatase, clathrin binding domain / OCRL1, PH domain / Inositol polyphosphate 5-phosphatase clathrin binding domain / : / : / Inositol polyphosphate 5-phosphatase OCRL-like, ASH domain / OCRL1/INPP5B, INPP5c domain / : / Inositol polyphosphate-related phosphatase ...PH-domain like - #110 / Inositol polyphosphate 5-phosphatase, clathrin binding domain / OCRL1, PH domain / Inositol polyphosphate 5-phosphatase clathrin binding domain / : / : / Inositol polyphosphate 5-phosphatase OCRL-like, ASH domain / OCRL1/INPP5B, INPP5c domain / : / Inositol polyphosphate-related phosphatase / Inositol polyphosphate phosphatase, catalytic domain homologues / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Endonuclease/exonuclease/phosphatase superfamily / Rho GTPase activation protein / PH-domain like / Roll / Immunoglobulin-like fold / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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Model details | lowest energy, model 1 |
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データ登録者 | Mao, Y. / Balkin, D.M. / Zoncu, R. / Erdmann, K. / Tomasini, L. / Hu, F. / Jin, M.M. / Hodsdon, M.E. / De Camilli, P. |
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引用 | ジャーナル: Embo J. / 年: 2009 タイトル: A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism 著者: Mao, Y. / Balkin, D.M. / Zoncu, R. / Erdmann, K.S. / Tomasini, L. / Hu, F. / Jin, M.M. / Hodsdon, M.E. / De Camilli, P. |
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履歴 | 登録 | 2009年5月3日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2009年7月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2022年3月16日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _struct_ref_seq_dif.details |
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