登録情報 データベース : PDB / ID : 2jf1 構造の表示 ダウンロードとリンクタイトル CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA2 CYTOPLASMIC TAIL PEPTIDE 要素FILAMIN-A INTEGRIN BETA-2 SUBUNIT 詳細キーワード CELL ADHESION / ACTIN-BINDING / TRANSMEMBRANE / ACETYLATION / POLYMORPHISM / CYTOSKELETON / GLYCOPROTEIN / FILAMIN / COMPLEX / MEMBRANE / INTEGRIN / RECEPTOR / PYRROLIDONE CARBOXYLIC ACID / PHOSPHORYLATION / DISEASE MUTATION / IMMUNOGLOBULIN LIKE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
integrin alphaX-beta2 complex / regulation of membrane repolarization during atrial cardiac muscle cell action potential / regulation of membrane repolarization during cardiac muscle cell action potential / positive regulation of neutrophil degranulation / cellular extravasation / establishment of Sertoli cell barrier / integrin alphaM-beta2 complex / Myb complex / integrin alphaL-beta2 complex / ICAM-3 receptor activity ... integrin alphaX-beta2 complex / regulation of membrane repolarization during atrial cardiac muscle cell action potential / regulation of membrane repolarization during cardiac muscle cell action potential / positive regulation of neutrophil degranulation / cellular extravasation / establishment of Sertoli cell barrier / integrin alphaM-beta2 complex / Myb complex / integrin alphaL-beta2 complex / ICAM-3 receptor activity / glycoprotein Ib-IX-V complex / adenylate cyclase-inhibiting dopamine receptor signaling pathway / formation of radial glial scaffolds / positive regulation of integrin-mediated signaling pathway / actin crosslink formation / tubulin deacetylation / cell-cell adhesion via plasma-membrane adhesion molecules / complement component C3b binding / blood coagulation, intrinsic pathway / protein localization to bicellular tight junction / OAS antiviral response / positive regulation of actin filament bundle assembly / Toll Like Receptor 4 (TLR4) Cascade / leukocyte migration involved in inflammatory response / positive regulation of neuron migration / neutrophil migration / Cell-extracellular matrix interactions / Fc-gamma receptor I complex binding / positive regulation of potassium ion transmembrane transport / apical dendrite / positive regulation of neural precursor cell proliferation / positive regulation of platelet activation / protein localization to cell surface / wound healing, spreading of cells / positive regulation of leukocyte adhesion to vascular endothelial cell / integrin complex / heterotypic cell-cell adhesion / podosome / negative regulation of transcription by RNA polymerase I / regulation of peptidyl-tyrosine phosphorylation / megakaryocyte development / leukocyte cell-cell adhesion / phagocytosis, engulfment / negative regulation of dopamine metabolic process / cell adhesion mediated by integrin / GP1b-IX-V activation signalling / receptor clustering / cortical cytoskeleton / SMAD binding / endodermal cell differentiation / RHO GTPases activate PAKs / amyloid-beta clearance / semaphorin-plexin signaling pathway / tertiary granule membrane / ficolin-1-rich granule membrane / cellular response to low-density lipoprotein particle stimulus / plasma membrane raft / cilium assembly / mitotic spindle assembly / positive regulation of protein targeting to membrane / Integrin cell surface interactions / potassium channel regulator activity / endothelial cell migration / specific granule membrane / cell adhesion molecule binding / heat shock protein binding / release of sequestered calcium ion into cytosol / neutrophil chemotaxis / positive regulation of substrate adhesion-dependent cell spreading / negative regulation of DNA-binding transcription factor activity / receptor-mediated endocytosis / protein sequestering activity / regulation of cell migration / positive regulation of superoxide anion generation / cell-matrix adhesion / dendritic shaft / integrin-mediated signaling pathway / protein localization to plasma membrane / Cell surface interactions at the vascular wall / actin filament / mRNA transcription by RNA polymerase II / microglial cell activation / establishment of protein localization / G protein-coupled receptor binding / cell-cell adhesion / negative regulation of protein catabolic process / cerebral cortex development / receptor internalization / small GTPase binding / positive regulation of protein import into nucleus / platelet aggregation / kinase binding / Z disc / positive regulation of angiogenesis / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / positive regulation of nitric oxide biosynthetic process / actin filament binding / integrin binding / Platelet degranulation / cell-cell junction 類似検索 - 分子機能 Integrin beta-2 subunit / Filamin family / Filamin/ABP280 repeat / Filamin-type immunoglobulin domains / Filamin/ABP280 repeat / Filamin/ABP280 repeat profile. / Filamin/ABP280 repeat-like / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. / Actinin-type actin-binding domain, conserved site ... Integrin beta-2 subunit / Filamin family / Filamin/ABP280 repeat / Filamin-type immunoglobulin domains / Filamin/ABP280 repeat / Filamin/ABP280 repeat profile. / Filamin/ABP280 repeat-like / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. / Actinin-type actin-binding domain, conserved site / Integrin beta subunit, cytoplasmic domain / Integrin beta cytoplasmic domain / Integrin_b_cyt / Integrin beta tail domain / Integrin EGF domain / Integrin beta subunit, tail / Integrin beta tail domain superfamily / Integrin_B_tail / Integrins beta chain EGF (I-EGF) domain profile. / Integrin beta subunit, VWA domain / Integrin beta subunit / Integrin beta N-terminal / Integrin beta chain VWA domain / Integrin plexin domain / Integrins beta chain EGF (I-EGF) domain signature. / Integrin beta subunits (N-terminal portion of extracellular region) / Calponin homology domain / Integrin domain superfamily / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / PSI domain / domain found in Plexins, Semaphorins and Integrins / von Willebrand factor A-like domain superfamily / EGF-like domain signature 1. / EGF-like domain signature 2. / Immunoglobulin E-set / Immunoglobulin-like fold / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Kiema, T. / Ylanne, J. 引用ジャーナル : Blood / 年 : 2008タイトル : Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding.著者 : Takala, H. / Nurminen, E. / Nurmi, S.M. / Aatonen, M. / Strandin, T. / Takatalo, M. / Kiema, T. / Gahmberg, C.G. / Ylanne, J. / Fagerholm, S.C. 履歴 登録 2007年1月25日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2008年2月5日 Provider : repository / タイプ : Initial release改定 1.1 2011年5月8日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2023年12月13日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
すべて表示 表示を減らす Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.