Entry Database : PDB / ID : 2j0i Structure visualization Downloads & linksTitle CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4 ComponentsSERINE/THREONINE-PROTEIN KINASE PAK 4 Details Keywords TRANSFERASE / PROTEIN KINASE / PHOSPHORYLATION / NUCLEOTIDE-BINDING / PAK4 / STE20 / KINASE / ATP-BINDING / ALTERNATIVE SPLICING / SERINE/THREONINE-PROTEIN KINASEFunction / homology Function and homology informationFunction Domain/homology Component
dendritic spine development / cadherin binding involved in cell-cell adhesion / Activation of RAC1 / RHOV GTPase cycle / RHOJ GTPase cycle / RHOQ GTPase cycle / regulation of MAPK cascade / CDC42 GTPase cycle / RHOH GTPase cycle / RHOU GTPase cycle ... dendritic spine development / cadherin binding involved in cell-cell adhesion / Activation of RAC1 / RHOV GTPase cycle / RHOJ GTPase cycle / RHOQ GTPase cycle / regulation of MAPK cascade / CDC42 GTPase cycle / RHOH GTPase cycle / RHOU GTPase cycle / cellular response to organic cyclic compound / RHOG GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / negative regulation of endothelial cell apoptotic process / cytoskeleton organization / RAC1 GTPase cycle / regulation of cell growth / adherens junction / positive regulation of angiogenesis / cell migration / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / cell cycle / phosphorylation / focal adhesion / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / Golgi apparatus / signal transduction / ATP binding / cytoplasm / cytosol Similarity search - Function p21 activated kinase binding domain / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 ... p21 activated kinase binding domain / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.6 Å DetailsAuthors Debreczeni, J.E. / Eswaran, J. / Ugochukwu, E. / Papagrigoriou, E. / Turnbull, A. / von Delft, F. / Arrowsmith, C. / Weigelt, J. / Edwards, A. / Sundstrom, M. / Knapp, S. CitationJournal : To be Published Title : Crystal Structure of the Human P21-Activated Kinase 4Authors : Debreczeni, J.E. / Eswaran, J. / Ugochukwu, E. / Papagrigoriou, E. / Turnbull, A. / von Delft, F. / Arrowsmith, C. / Weigelt, J. / Edwards, A. / Sundstrom, M. / Knapp, S. History Deposition Aug 3, 2006 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 17, 2006 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Jan 24, 2018 Group : Database references / Structure summary / Category : audit_author / citation_author / Item : _audit_author.name / _citation_author.nameRevision 1.4 Jan 31, 2018 Group : Source and taxonomy / Category : entity_src_genItem : _entity_src_gen.pdbx_host_org_cell_line / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_nameRevision 1.5 May 8, 2019 Group : Data collection / Derived calculations / Experimental preparationCategory : database_PDB_rev / database_PDB_rev_record ... database_PDB_rev / database_PDB_rev_record / exptl_crystal_grow / struct_conn Item : _exptl_crystal_grow.method / _exptl_crystal_grow.temp / _struct_conn.pdbx_leaving_atom_flagRevision 1.6 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
Show all Show less