Entry Database : PDB / ID : 2ix7 Structure visualization Downloads & linksTitle Structure of apo-calmodulin bound to unconventional myosin V ComponentsCALMODULIN MYOSIN-5A DetailsKeywords CONTRACTILE PROTEIN/METAL BINDING / ACTIN-BINDING / UBL CONJUGATION / CA2+ REGULATION / MYOSIN / CALCIUM / IQ MOTIF / CALMODULIN / ACETYLATION / NUCLEOTIDE- BINDING / CONTRACTILE PROTEIN / COMPLEX / PHOSPHORYLATION / CALMODULIN-BINDING / METAL BINDING / METHYLATION / COILED COIL / ATP-BINDING / MOTOR PROTEIN / CONTRACTILE PROTEIN-METAL BINDING complexFunction / homology Function and homology informationFunction Domain/homology Component
actomyosin, myosin complex part / establishment of endoplasmic reticulum localization to postsynapse / axo-dendritic protein transport / positive regulation of cellular response to insulin stimulus / endoplasmic reticulum localization / melanosome localization / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) ... actomyosin, myosin complex part / establishment of endoplasmic reticulum localization to postsynapse / axo-dendritic protein transport / positive regulation of cellular response to insulin stimulus / endoplasmic reticulum localization / melanosome localization / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) / Activation of RAC1 downstream of NMDARs / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / Activation of Ca-permeable Kainate Receptor / CLEC7A (Dectin-1) induces NFAT activation / Synthesis of IP3 and IP4 in the cytosol / RHO GTPases activate PAKs / Calmodulin induced events / Inactivation, recovery and regulation of the phototransduction cascade / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / Calcineurin activates NFAT / eNOS activation / Ion transport by P-type ATPases / Unblocking of NMDA receptors, glutamate binding and activation / locomotion involved in locomotory behavior / Protein methylation / reactive gliosis / melanin metabolic process / RAF activation / VEGFR2 mediated vascular permeability / RAS processing / Smooth Muscle Contraction / Ca2+ pathway / negative regulation of calcium ion transmembrane transporter activity / unconventional myosin complex / FCERI mediated Ca+2 mobilization / post-Golgi vesicle-mediated transport / RAF/MAP kinase cascade / RHO GTPases activate IQGAPs / Extra-nuclear estrogen signaling / insulin-responsive compartment / negative regulation of dopamine secretion / developmental pigmentation / regulation of postsynaptic cytosolic calcium ion concentration / melanosome transport / actin filament-based movement / PKA activation / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / secretory granule localization / melanin biosynthetic process / Platelet degranulation / Regulation of actin dynamics for phagocytic cup formation / filopodium tip / hair follicle maturation / melanocyte differentiation / postsynaptic actin cytoskeleton / : / establishment of protein localization to mitochondrial membrane / Stimuli-sensing channels / actomyosin / regulation of exocytosis / Ion homeostasis / type 3 metabotropic glutamate receptor binding / negative regulation of synaptic transmission, glutamatergic / vesicle transport along actin filament / ATP-dependent protein binding / positive regulation of vascular associated smooth muscle cell migration / long-chain fatty acid biosynthetic process / syntaxin-1 binding / insulin secretion / myosin complex / intermediate filament / odontogenesis / pigmentation / regulation of synaptic vesicle endocytosis / microfilament motor activity / negative regulation of high voltage-gated calcium channel activity / regulation of synaptic vesicle exocytosis / negative regulation of calcium ion export across plasma membrane / dopamine metabolic process / organelle localization by membrane tethering / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / response to corticosterone / positive regulation of ryanodine-sensitive calcium-release channel activity / nitric-oxide synthase binding / exocytosis / protein phosphatase activator activity / smooth endoplasmic reticulum / positive regulation of cyclic-nucleotide phosphodiesterase activity / cytoskeletal motor activity / positive regulation of phosphoprotein phosphatase activity / adenylate cyclase binding / catalytic complex / photoreceptor outer segment / detection of calcium ion / negative regulation of ryanodine-sensitive calcium-release channel activity Similarity search - Function Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #190 / Myosin 5a, cargo-binding domain / Class V myosin, motor domain / Dilute domain / DIL domain / Dilute domain profile. / DIL / IQ calmodulin-binding motif / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. ... Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #190 / Myosin 5a, cargo-binding domain / Class V myosin, motor domain / Dilute domain / DIL domain / Dilute domain profile. / DIL / IQ calmodulin-binding motif / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Short calmodulin-binding motif containing conserved Ile and Gln residues. / Myosin head, motor domain / Myosin head (motor domain) / Myosin motor domain profile. / Myosin. Large ATPases. / IQ motif profile. / IQ motif, EF-hand binding site / Kinesin motor domain superfamily / EF-hand / Recoverin; domain 1 / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species MUS MUSCULUS (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MIRAS / Resolution : 2.5 Å DetailsAuthors Houdusse, A. / Gaucher, J.F. / Mui, S. / Krementsova, E. / Trybus, K.M. / Cohen, C. CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2006Title : Crystal Structure of Apo-Calmodulin Bound to the First Two Iq Motifs of Myosin V Reveals Essential Recognition Features.Authors : Houdusse, A. / Gaucher, J.F. / Krementsova, E. / Mui, S. / Trybus, K.M. / Cohen, C. History Deposition Jul 7, 2006 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 13, 2006 Provider : repository / Type : Initial releaseRevision 1.1 Dec 4, 2013 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Non-polymer description / Other / Refinement description / Source and taxonomy / Version format compliance Revision 1.2 Feb 27, 2019 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Experimental preparation / Other Category : exptl_crystal_grow / pdbx_database_proc ... exptl_crystal_grow / pdbx_database_proc / pdbx_database_status / struct_biol / struct_conn Item : _exptl_crystal_grow.method / _exptl_crystal_grow.temp ... _exptl_crystal_grow.method / _exptl_crystal_grow.temp / _pdbx_database_status.recvd_author_approval / _struct_conn.pdbx_leaving_atom_flag Revision 1.3 Nov 8, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_conn / struct_conn_type / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn_type.id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.4 Dec 13, 2023 Group : Refinement description / Category : pdbx_initial_refinement_model
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