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- PDB-2hgf: HAIRPIN LOOP CONTAINING DOMAIN OF HEPATOCYTE GROWTH FACTOR, NMR, ... -
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Open data
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Basic information
Entry | Database: PDB / ID: 2hgf | ||||||
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Title | HAIRPIN LOOP CONTAINING DOMAIN OF HEPATOCYTE GROWTH FACTOR, NMR, MINIMIZED AVERAGE STRUCTURE | ||||||
![]() | HEPATOCYTE GROWTH FACTOR | ||||||
![]() | HEPATOCYTE GROWTH FACTOR / SCATTER FACTOR / HAIRPIN LOOP / HEPARIN BINDING / PLASMINOGEN RELATED / NK1 | ||||||
Function / homology | ![]() regulation of p38MAPK cascade / regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling / Drug-mediated inhibition of MET activation / skeletal muscle cell proliferation / MET activates STAT3 / negative regulation of hydrogen peroxide-mediated programmed cell death / MET interacts with TNS proteins / MET Receptor Activation / hepatocyte growth factor receptor signaling pathway / MET receptor recycling ...regulation of p38MAPK cascade / regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling / Drug-mediated inhibition of MET activation / skeletal muscle cell proliferation / MET activates STAT3 / negative regulation of hydrogen peroxide-mediated programmed cell death / MET interacts with TNS proteins / MET Receptor Activation / hepatocyte growth factor receptor signaling pathway / MET receptor recycling / MET activates PTPN11 / MET activates RAP1 and RAC1 / myoblast proliferation / MET activates PI3K/AKT signaling / MET activates PTK2 signaling / cellular response to hepatocyte growth factor stimulus / positive regulation of DNA biosynthetic process / chemoattractant activity / negative regulation of release of cytochrome c from mitochondria / negative regulation of peptidyl-serine phosphorylation / positive regulation of interleukin-10 production / negative regulation of interleukin-6 production / epithelial to mesenchymal transition / positive regulation of osteoblast differentiation / MET activates RAS signaling / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / Interleukin-7 signaling / negative regulation of autophagy / cell chemotaxis / platelet alpha granule lumen / liver development / epithelial cell proliferation / growth factor activity / cell morphogenesis / Negative regulation of MET activity / negative regulation of inflammatory response / Constitutive Signaling by Aberrant PI3K in Cancer / Platelet degranulation / PIP3 activates AKT signaling / mitotic cell cycle / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / Interleukin-4 and Interleukin-13 signaling / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of cell migration / positive regulation of protein phosphorylation / signaling receptor binding / negative regulation of apoptotic process / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / identical protein binding / membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR / DISTANCE-GEOMETRY SIMULATED ANNEALING | ||||||
![]() | Zhou, H. / Mazzulla, M.J. / Kaufman, J.D. / Stahl, S.J. / Wingfield, P.T. / Rubin, J.S. / Bottaro, D.P. / Byrd, R.A. | ||||||
![]() | ![]() Title: The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. Authors: Zhou, H. / Mazzulla, M.J. / Kaufman, J.D. / Stahl, S.J. / Wingfield, P.T. / Rubin, J.S. / Bottaro, D.P. / Byrd, R.A. #1: ![]() Title: Functional and Biophysical Characterization of Recombinant Human Hepatocyte Growth Factor Isoforms Produced in Escherichia Coli Authors: Stahl, S.J. / Wingfield, P.T. / Kaufman, J.D. / Pannell, L.K. / Cioce, V. / Sakata, H. / Taylor, W.G. / Rubin, J.S. / Bottaro, D.P. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 43.1 KB | Display | ![]() |
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PDB format | ![]() | 33.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 245 KB | Display | ![]() |
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Full document | ![]() | 244.8 KB | Display | |
Data in XML | ![]() | 5.7 KB | Display | |
Data in CIF | ![]() | 7.2 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein | Mass: 11401.286 Da / Num. of mol.: 1 / Fragment: AMINO TERMINAL DOMAIN Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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NMR experiment | Type: SEE REFERENCE. |
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Sample preparation
Sample conditions | pH: 6.8 / Temperature: 303 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
NMR spectrometer | Type: Varian UNITYPLUS / Manufacturer: Varian / Model: UNITYPLUS / Field strength: 600 MHz |
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Processing
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NMR software |
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Refinement | Method: DISTANCE-GEOMETRY SIMULATED ANNEALING / Software ordinal: 1 | ||||||||||||
NMR ensemble | Conformer selection criteria: RESTRAINED, MINIMIZED MEAN STRUCTURE Conformers calculated total number: 60 / Conformers submitted total number: 1 |