登録情報 データベース : PDB / ID : 2cgo 構造の表示 ダウンロードとリンクタイトル FACTOR INHIBITING HIF-1 ALPHA with fumarate 要素HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR 詳細 キーワード OXIDOREDUCTASE / 2-OXOGLUTARATE / ACETYLATION / ACTIVATOR / ALTERNATIVE SPLICING / ASPARAGINYL HYDROXYLASE / DNA-BINDING / DSBH / FI / HIF / HYDROXYLATION / HYPOXIA / NUCLEAR PROTEIN / OXYGENASE / PHOSPHORYLATION / POLYMORPHISM / S-NITROSYLATION / TRANSCRIPTION / TRANSCRIPTION ACTIVATOR/INHIBITOR / TRANSCRIPTION REGULATION / DIOXYGENASE / IRON / METAL-BINDING機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
hypoxia-inducible factor-asparagine dioxygenase / : / [protein]-asparagine 3-dioxygenase activity / peptidyl-histidine dioxygenase activity / peptidyl-aspartic acid 3-dioxygenase activity / Cellular response to hypoxia / carboxylic acid binding / positive regulation of vasculogenesis / ankyrin repeat binding / oxygen sensor activity ... hypoxia-inducible factor-asparagine dioxygenase / : / [protein]-asparagine 3-dioxygenase activity / peptidyl-histidine dioxygenase activity / peptidyl-aspartic acid 3-dioxygenase activity / Cellular response to hypoxia / carboxylic acid binding / positive regulation of vasculogenesis / ankyrin repeat binding / oxygen sensor activity / Notch binding / negative regulation of Notch signaling pathway / NF-kappaB binding / positive regulation of myoblast differentiation / ferrous iron binding / transcription corepressor activity / perinuclear region of cytoplasm / protein homodimerization activity / zinc ion binding / nucleoplasm / cytoplasm / cytosol 類似検索 - 分子機能 Clavaminate synthase-like / Hypoxia-inducible factor 1-alpha inhibitor, domain II / Cupin-like domain 8 / Cupin-like domain / A domain family that is part of the cupin metalloenzyme superfamily. / Jelly Rolls / JmjC domain / JmjC domain profile. / RmlC-like jelly roll fold / Helix Hairpins ... Clavaminate synthase-like / Hypoxia-inducible factor 1-alpha inhibitor, domain II / Cupin-like domain 8 / Cupin-like domain / A domain family that is part of the cupin metalloenzyme superfamily. / Jelly Rolls / JmjC domain / JmjC domain profile. / RmlC-like jelly roll fold / Helix Hairpins / Jelly Rolls / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha 類似検索 - ドメイン・相同性 : / FUMARIC ACID / Hypoxia-inducible factor 1-alpha inhibitor 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.3 Å 詳細データ登録者 McDonough, M.A. / Clifton, I.J. / Schofield, C.J. 引用ジャーナル : J.Biol.Chem. / 年 : 2007タイトル : Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates.著者 : Hewitson, K. / Lienard, B. / McDonough, M.A. / Clifton, I.J. / Butler, D. / Soares, A.S. / Oldham, N.J. / McNeill, L.A. / Schofield, C.J. 履歴 登録 2006年3月9日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2006年12月13日 Provider : repository / タイプ : Initial release改定 1.1 2012年7月18日 Group : Atomic model / Derived calculations ... Atomic model / Derived calculations / Non-polymer description / Other / Version format compliance 改定 1.2 2018年2月21日 Group : Database references / Structure summary / カテゴリ : audit_author / citation / citation_authorItem : _audit_author.name / _citation.page_last / _citation_author.name改定 2.0 2023年11月15日 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations / Other カテゴリ : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_struct_conn_angle / struct_conn / struct_site Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 2.1 2023年12月13日 Group : Refinement description / カテゴリ : pdbx_initial_refinement_model
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