Entry Database : PDB / ID : 1uuh Structure visualization Downloads & linksTitle Hyaluronan binding domain of human CD44 ComponentsCD44 ANTIGEN Details Keywords LECTIN / HYALURONAN / EXTRACELLULAR MATRIX / RECEPTOR / LINK-DOMAIN / C- TYPE LECTIN / SUGAR-BINDINGFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of monocyte aggregation / Hyaluronan uptake and degradation / hyaluronic acid binding / monocyte aggregation / macrophage migration inhibitory factor receptor complex / regulation of lamellipodium morphogenesis / hyaluronan catabolic process / cellular response to fibroblast growth factor stimulus / positive regulation of heterotypic cell-cell adhesion / cartilage development ... positive regulation of monocyte aggregation / Hyaluronan uptake and degradation / hyaluronic acid binding / monocyte aggregation / macrophage migration inhibitory factor receptor complex / regulation of lamellipodium morphogenesis / hyaluronan catabolic process / cellular response to fibroblast growth factor stimulus / positive regulation of heterotypic cell-cell adhesion / cartilage development / wound healing, spreading of cells / cytokine receptor activity / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / negative regulation of DNA damage response, signal transduction by p53 class mediator / microvillus / lamellipodium membrane / Integrin cell surface interactions / collagen binding / T cell activation / Degradation of the extracellular matrix / cell-matrix adhesion / secretory granule membrane / cell projection / Cell surface interactions at the vascular wall / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / cell-cell adhesion / transmembrane signaling receptor activity / positive regulation of peptidyl-tyrosine phosphorylation / Interferon gamma signaling / cell migration / positive regulation of peptidyl-serine phosphorylation / basolateral plasma membrane / positive regulation of ERK1 and ERK2 cascade / cell adhesion / inflammatory response / apical plasma membrane / focal adhesion / Neutrophil degranulation / negative regulation of apoptotic process / Golgi apparatus / cell surface / extracellular exosome / plasma membrane / cytosol Similarity search - Function CD44 antigen / CD44 antigen-like / Link domain / Extracellular link domain / Link domain signature. / Link domain profile. / Link (Hyaluronan-binding) / C-type lectin-like/link domain superfamily / C-type lectin fold Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / OTHER / Resolution : 2.2 Å DetailsAuthors Teriete, P. / Banerji, S. / Noble, M. / Blundell, C. / Wright, A. / Pickford, A. / Lowe, E. / Mahoney, D. / Tammi, M. / Kahmann, J. ...Teriete, P. / Banerji, S. / Noble, M. / Blundell, C. / Wright, A. / Pickford, A. / Lowe, E. / Mahoney, D. / Tammi, M. / Kahmann, J. / Campbell, I. / Day, A. / Jackson, D. CitationJournal : Mol.Cell / Year : 2004Title : Structure of the Regulatory Hyaluronan-Binding Domain in the Inflammatory Leukocyte Homing Receptor Cd44Authors : Teriete, P. / Banerji, S. / Noble, M. / Blundell, C. / Wright, A. / Pickford, A. / Lowe, E. / Mahoney, D. / Tammi, M. / Kahmann, J. / Campbell, I. / Day, A. / Jackson, D. History Deposition Dec 19, 2003 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 4, 2004 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 May 29, 2019 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Experimental preparation / Other Category : exptl_crystal_grow / pdbx_database_proc ... exptl_crystal_grow / pdbx_database_proc / pdbx_database_status / struct_biol / struct_conn Item : _exptl_crystal_grow.method / _pdbx_database_status.recvd_author_approval / _struct_conn.pdbx_leaving_atom_flag
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