登録情報 データベース : PDB / ID : 1sy6 構造の表示 ダウンロードとリンクタイトル Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment 要素OKT3 Fab heavy chain OKT3 Fab light chain T-cell surface glycoprotein CD3 gamma/epsilon chain 詳細キーワード signaling protein/antibiotic / CD3 gamma / CD3 epsilon / OKT3 Fab / signaling protein-antibiotic COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of lymphocyte apoptotic process / gamma-delta T cell receptor complex / T cell anergy / positive regulation of T cell anergy / positive regulation of cell-cell adhesion mediated by integrin / CD4-positive, alpha-beta T cell proliferation / gamma-delta T cell activation / negative thymic T cell selection / positive regulation of CD4-positive, alpha-beta T cell proliferation / alpha-beta T cell receptor complex ... regulation of lymphocyte apoptotic process / gamma-delta T cell receptor complex / T cell anergy / positive regulation of T cell anergy / positive regulation of cell-cell adhesion mediated by integrin / CD4-positive, alpha-beta T cell proliferation / gamma-delta T cell activation / negative thymic T cell selection / positive regulation of CD4-positive, alpha-beta T cell proliferation / alpha-beta T cell receptor complex / positive thymic T cell selection / signal complex assembly / positive regulation of cell-matrix adhesion / T cell receptor complex / smoothened signaling pathway / establishment or maintenance of cell polarity / positive regulation of interleukin-4 production / dendrite development / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / alpha-beta T cell activation / Generation of second messenger molecules / immunological synapse / FCGR activation / PD-1 signaling / Role of phospholipids in phagocytosis / T cell receptor binding / positive regulation of calcium-mediated signaling / negative regulation of smoothened signaling pathway / positive regulation of T cell proliferation / immunoglobulin complex, circulating / immunoglobulin receptor binding / cell surface receptor protein tyrosine kinase signaling pathway / T cell costimulation / T cell activation / positive regulation of interleukin-2 production / cerebellum development / FCGR3A-mediated IL10 synthesis / complement activation, classical pathway / calcium-mediated signaling / apoptotic signaling pathway / FCGR3A-mediated phagocytosis / antigen binding / clathrin-coated endocytic vesicle membrane / Regulation of actin dynamics for phagocytic cup formation / SH3 domain binding / transmembrane signaling receptor activity / positive regulation of peptidyl-tyrosine phosphorylation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / positive regulation of type II interferon production / cell-cell junction / protein transport / signaling receptor complex adaptor activity / Downstream TCR signaling / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / T cell receptor signaling pathway / cell body / antibacterial humoral response / protein-containing complex assembly / regulation of apoptotic process / adaptive immune response / dendritic spine / cell surface receptor signaling pathway / blood microparticle / G protein-coupled receptor signaling pathway / external side of plasma membrane / negative regulation of gene expression / positive regulation of gene expression / protein kinase binding / Golgi apparatus / endoplasmic reticulum / extracellular exosome / identical protein binding / plasma membrane / cytosol 類似検索 - 分子機能 CD3 gamma/delta subunit, Ig-like domain / T-cell surface glycoprotein CD3 delta chain / Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain / CD3 protein, epsilon/gamma/delta subunit / Immunoreceptor tyrosine-based activation motif / Phosphorylated immunoreceptor signalling ITAM / ITAM motif mammalian type profile. / Immunoreceptor tyrosine-based activation motif / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type ... CD3 gamma/delta subunit, Ig-like domain / T-cell surface glycoprotein CD3 delta chain / Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain / CD3 protein, epsilon/gamma/delta subunit / Immunoreceptor tyrosine-based activation motif / Phosphorylated immunoreceptor signalling ITAM / ITAM motif mammalian type profile. / Immunoreceptor tyrosine-based activation motif / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性 T-cell surface glycoprotein CD3 epsilon chain / T-cell surface glycoprotein CD3 gamma chain / Igh protein 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ)Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.1 Å 詳細データ登録者 Kjer-Nielsen, L. / Dunstone, M.A. / Kostenko, L. / Ely, L.K. / Beddoe, T. / Misfud, N.A. / Purcell, A.W. / Brooks, A.G. / McCluskey, J. / Rossjohn, J. 引用ジャーナル : Proc.Natl.Acad.Sci.USA / 年 : 2004タイトル : Crystal structure of the human T cell receptor CD3(epsilon)(gamma) heterodimer complexed to the therapeutic mAb OKT3.著者 : Kjer-Nielsen, L. / Dunstone, M.A. / Kostenko, L. / Ely, L.K. / Beddoe, T. / Mifsud, N.A. / Purcell, A.W. / Brooks, A.G. / McCluskey, J. / Rossjohn, J. 履歴 登録 2004年3月31日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2004年5月25日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月30日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2017年8月2日 Group : Refinement description / Source and taxonomy / カテゴリ : entity_src_gen / software改定 1.4 2018年4月4日 Group : Data collection / カテゴリ : diffrn_source / Item : _diffrn_source.type
すべて表示 表示を減らす Remark 999 SEQUENCE The sequence of OKT3 Fab light chain and heavy chain are not available in any of the ... SEQUENCE The sequence of OKT3 Fab light chain and heavy chain are not available in any of the database. The protein T-CELL SURFACE GLYCOPROTEIN CD3 Gamma/epsilon CHAIN has original sequence 0-81 of gamma chain bond to sequence 1-96 of epsilon chain with 26 residues linker (GSADDAKK DAAKKDDAKK DDAKKDGS) in between.